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CRBN Products

(Cereblon (CRBN))

Categories

This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

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Featured CRBN Categories

CRBN Antibodies

High quality antibodies with extensive validation data.

CRBN ELISA Kits

Reliable ELISA kits for a wide range of species.

CRBN Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CRBN Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7165198
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (3)
  • (1)
Cat. No. ABIN526543
Quantity 50 μg
Datasheet Datasheet

Application WB
Validations
  • (1)
Cat. No. ABIN6744097
Quantity 100 μL
Datasheet Datasheet

Recommended CRBN ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965629
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954563
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954564
Quantity 96 tests
Datasheet Datasheet

Recommended CRBN Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1350279
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122244
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122245
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our CRBN products

Donovan, An, Nowak, Yuan, Fink, Berry, Ebert, Fischer: "Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome." in: eLife, Vol. 7, (2019) (PubMed).

Girardini, Maniaci, Hughes, Testa, Ciulli: "Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs." in: Bioorganic & medicinal chemistry, Vol. 27, Issue 12, pp. 2466-2479, (2019) (PubMed).

de Wispelaere, Du, Donovan, Zhang, Eleuteri, Yuan, Kalabathula, Nowak, Fischer, Gray, Yang: "Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations." in: Nature communications, Vol. 10, Issue 1, pp. 3468, (2019) (PubMed).

Zoppi, Hughes, Maniaci, Testa, Gmaschitz, Wieshofer, Koegl, Riching, Daniels, Spallarossa, Ciulli et al.: "Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of ..." in: Journal of medicinal chemistry, (2018) (PubMed).

Olson, Jiang, Erb, Liang, Doctor, Zhang, Zhang, Kwiatkowski, Boukhali, Green, Haas, Nomanbhoy, Fischer, Young, Bradner, Winter, Gray: "Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation." in: Nature chemical biology, Vol. 14, Issue 2, pp. 163-170, (2018) (PubMed).

Basiorka, McGraw, De Ceuninck, Griner, Zhang, Clark, Caceres, Sokol, Komrokji, Reuther, Wei, Tavernier, List: "Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41." in: Cancer research, Vol. 76, Issue 12, pp. 3531-40, (2016) (PubMed).

Peng, Li, Clarkson, Pehar, Lao, Hillmer, Barnhart, Christian, Mitchell, Bendlin, Sandor, Puglielli: "Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 20, pp. 6772-89, (2014) (PubMed).

Liu, Ye, Zou, Xu, Feng, Zou, Chen, Li, Cang: "CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis." in: Nature communications, Vol. 5, pp. 3924, (2014) (PubMed).

Gandhi, Mendy, Waldman, Chen, Rychak, Miller, Gaidarova, Ren, Wang, Breider, Carmel, Mahmoudi, Jackson, Abbasian, Cathers, Schafer, Daniel, Lopez-Girona, Thakurta, Chopra: "Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity." in: British journal of haematology, Vol. 164, Issue 2, pp. 233-44, (2014) (PubMed).

Charoenfuprasert, Yang, Lee, Chao, Chu, Lai, Hsu, Chang, Chen, Chen, Chang, Leu, Shih: "Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer." in: Oncogene, Vol. 30, Issue 33, pp. 3570-84, (2011) (PubMed).

Synonyms and alternative names related to CRBN

cereblon (crbn), cereblon (CRBN), ATP-dependent protease La (LON) domain protein (AT2G25740), cereblon (Crbn), 2610203G15Rik, 2900045O07Rik, AF229032, AW108261, F3N11.21, MRT2, mrt2a, MRT2A, piL, zgc:92404

Protein level used designations for CRBN

  • protein cereblon
  • zcrbn
  • cereblon
  • protein cereblon-like
  • protein x 0001
  • novel lethal
  • protein PiL
  • Protein cereblon
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