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The protein encoded by CCR4 belongs to the G-protein-coupled receptor family . Additionally we are shipping CCR4 Kits (20) and CCR4 Proteins (4) and many more products for this protein.
Showing 10 out of 163 products:
Human Monoclonal CCR4 Primary Antibody for cELISA, FACS - ABIN179723
Andrew, Ruffing, Kim, Miao, Heath, Li, Murphy, Campbell, Butcher, Wu: C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 5 references for ABIN179723
Cow (Bovine) Polyclonal CCR4 Primary Antibody for EIA, IHC (fro) - ABIN492852
Tran, Miller: Chemokine receptors: signposts to brain development and disease. in Nature reviews. Neuroscience 2003
Show all 3 references for ABIN492852
Cow (Bovine) Polyclonal CCR4 Primary Antibody for WB - ABIN2792190
Nakayama, Hieshima, Arao, Jin, Nagakubo, Shirakawa, Yamada, Fujii, Oiso, Kawada, Nishio, Yoshie: Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. in Oncogene 2008
Human Polyclonal CCR4 Primary Antibody for IF (p), IHC (p) - ABIN738666
Ge, Li, Jiang, You, Liu, Zhong, Huang, Xing: Integration of nondegradable polystyrene and degradable gelatin in a core-sheath nanofibrous patch for pelvic reconstruction. in International journal of nanomedicine 2015
CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.
CCL22 (show CCL22 Antibodies) was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells
CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes
results show that the IL-4 (show IL4 Antibodies)/CCL22 (show CCL22 Antibodies)/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators
These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
that effective engagement of CCR4 by CCL17 (show CCL17 Antibodies) involves two distinct binding domains and interaction with both is required for signaling
NF-kappaB (show NFKB1 Antibodies) signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role
CCR4-expressing Th2cells play a critical role in the pathogenesis of bronchial asthma by producing Th2 cytokines.
CCR4 promotes natural killer cell priming/activation by mediating contacts with sentinel cells in the lung.
Combining a panel of thymocyte maturation markers with cell surface analysis of CCR7 (show CCR7 Antibodies) and CCR4 identifies distinct stages in the development of multiple alphabetaT cell lineages in the adult thymus.
CCL22 (show CCL22 Antibodies)-specific antibodies reveal that engagement of two distinct binding domains on CCL22 (show CCL22 Antibodies) is required for CCR4-mediated function.
CCR4 mutation is an important determinant of the clinical course in ATLL cases, and that NS and FS mutations of CCR4 behave differently with respect to ATLL pathophysiology.
Distinctive Treg associated CCR4-CCL22 (show CCL22 Antibodies) expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris (show DSG3 Antibodies).
Data show that CCR4 was over-expressed in lymph node-negative human gastric cancer tissues and suggest its involvement in promoting tumor invasion probably, through up-regulation of MMP9 (show MMP9 Antibodies).
CCR4 C1014T and CCL22 (show CCL22 Antibodies) C16A genetic variations were neither associated with the risk, nor with the progression of colorectal cancer in Iranian population
Higher percentages of CCR4+ CD4 (show CD4 Antibodies) TEM (show CYLD Antibodies) cells in acute RSV infection were accompanied with higher percentages of CXCR3 (show CXCR3 Antibodies)+ CD8 (show CD8A Antibodies) TEM (show CYLD Antibodies) cells, whereas the development of long-lived memory CXCR3 (show CXCR3 Antibodies)+ CD4 (show CD4 Antibodies) and CD8 (show CD8A Antibodies) TCM cells seems to be compromised
These findings implicate somatic gain-of-function CCR4 mutations in the pathogenesis of adult T cell leukemia/lymphoma.
CCR4 has a role in tumor aggressive behavior in renal cell carcinoma (show MOK Antibodies)
Data show that CCR4 exists in at least two distinct conformations, which are differentially activated by ligand.
CCR4 mediates CCL17 (show CCL17 Antibodies) induced cell migration via increased total RhoA (show RHOA Antibodies) and active RhoA (show RHOA Antibodies) protein levels in colon cancer cells.
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
chemokine (C-C motif) receptor 4
, C-C chemokine receptor type 4-like
, c-C chemokine receptor type 4-like
, CCR4-NOT transcription complex subunit 6
, carbon catabolite repressor protein 4 homolog
, cytoplasmic deadenylase
, C-C CKR-4
, C-C chemokine receptor type 4
, chemokine (C-C) receptor 4
, CC chemokine receptor 4
, leukocyte-expressed seven-transmembrane-domain receptor
, C-C chemokine receptor 4