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Chemokine (C-X-C Motif) Receptor 1 Proteins (CXCR1)

The protein encoded by CXCR1 is a member of the G-protein-coupled receptor family. Additionally we are shipping CXCR1 Antibodies (97) and CXCR1 Kits (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CXCR1 3577 P25024
CXCR1 227288 Q810W6
Rat CXCR1 CXCR1 54258 P70612
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Top CXCR1 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   5 applications Log in to see 1 to 2 Days

CXCR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine) ,

Top referenced CXCR1 Proteins

  1. Human CXCR1 Protein expressed in Wheat germ - ABIN1330036 : Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014 (PubMed)

  2. Human CXCR1 Protein expressed in Wheat germ - ABIN1350834 : Bergin, Reeves, Meleady, Henry, McElvaney, Carroll, Condron, Chotirmall, Clynes, ONeill, McElvaney: ?-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. in The Journal of clinical investigation 2010 (PubMed)

More Proteins for Chemokine (C-X-C Motif) Receptor 1 (CXCR1) Interaction Partners

Cow (Bovine) Chemokine (C-X-C Motif) Receptor 1 (CXCR1) interaction partners

  1. (PCR) was used to detect the methylation status of CXCR1 CpG island, and quantitative fluorescence PCR was used to detect CXCR1 expression in bovine mammary tissue

  2. Polymorphisms in CXCR1 are significantly associated with bovine mastitis

  3. In the present study no association could be detected between superoxide production by isolated bovine neutrophils during early lactation and CXCR1 gene polymorphism. IL-8 (show IL8 Proteins) showed to possess inhibitory effects on ROS (show ROS1 Proteins) generation in bovine neutrophils.

  4. CXCR1 polymorphisms influence viability and concentration of milk polymorphonuclear neutrophilic leukocytes.

  5. The results suggests the possible role of CXCR1 gene SNPs in the host response against mastitis.

  6. The situation of CXCR1 polymorphisms in Chinese Holstein cattle and determine the relationship between the CXCR1 SNPs and mastitis resistance.

  7. Association between interleukin-8 receptor-alpha (CXCR1) polymorphism and disease incidence, production, reproduction, and survival in Holstein cows.

  8. The aim of this study was to demonstrate the presence of the two SNPs in the CXCR1 gene of Japanese Black cattle and examine the association between the SNPs and clinical diseases including intestinal and respiratory diseases in calves.

  9. Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.

  10. no statistically significant association of the SNP CXCR1+777 or CXCR1-1768 with SCS (show TWIST1 Proteins) was found

Human Chemokine (C-X-C Motif) Receptor 1 (CXCR1) interaction partners

  1. Evaluation of GPER1, EGFR (show EGFR Proteins) and CXCR1 mRNA/protein expression may be helpful in differential diagnosis of malignant follicular thyroid carcinoma and benign follicular thyroid adenoma.

  2. These studies provide direct evidence linking the activation of IL8 (show IL8 Proteins), DNA demethylation and the induction of the OA process with important therapeutic implications therein for patients with this debilitating disease.

  3. Studied the expression of CXCL8 (show IL8 Proteins)-CXCR1/2 pathway, its impact on cell proliferation and cytokine expression in human colorectal carcinoma HCT116 cells.

  4. Inhibition of IL-8 (show IL8 Proteins) signalling can enhance response in platinum sensitive and resistant high grade serous ovarian carcinoma.

  5. CXCR2 (show CXCR2 Proteins) expression is enriched in human atherosclerotic coronary artery.

  6. CXCR2-CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma

  7. we found the mRNA level of NF-kappaB (show NFKB1 Proteins) and IL-8 (show IL8 Proteins) was higher in gastric ulcer patients, especially in patients with H.pylori-positive gastric ulcer.

  8. Data show that trefoil factor-3 (TFF3 (show TFF3 Proteins)) secreted from mammary carcinoma cells promotes de novo angiogenesis via interleukin-8 (IL-8 (show IL8 Proteins))/IL-8 (show IL8 Proteins) receptor CXCR2 (show CXCR2 Proteins).

  9. G31P blockage of CXCR1 and CXCR2 (show CXCR2 Proteins) can inhibit human lung cancer cell growth and metastasis

  10. Study shows that CXCL5 (show CXCL5 Proteins) expression is elevated in positive correlation to bladder cancer grade and promotes cell migration and invasion via binding to its receptor CXCR2 (show CXCR2 Proteins).

Mouse (Murine) Chemokine (C-X-C Motif) Receptor 1 (CXCR1) interaction partners

  1. in view of recently-published experimental data obtained in NOD mice, we argue for possible Cxcr1 involvement in type 1 diabetes pathogenesi

  2. CXCR1 expression is induced in staphylococcus aureus-infected macrophages but not in control macrophages.

  3. Pharmacologic blockade of CXCR1/2 as well as genetic deletion of NAP-2 (show PPBP Proteins) markedly reduced leukocyte shape change and intrathrombus migration.

  4. Blockade of the CXCL1-CXCR1/2 axis in mice improved intrahepatic islet engraftment. The CXCR1/2-mediated pathway is a regulator of islet damage.

  5. Upon activation by CXCL8 (show IL8 Proteins), CXCR1 predominantly couples to G protein-coupled receptor (show GPR34 Proteins) kinase (GRK)2 (show ADRBK1 Proteins) to modulate leukocyte functions.

  6. Xiaotan Sanjie Decoction XTSJD can decrease the protein expressions of IL-8 (show IL8 Proteins) and its receptors CXCR1/CXCR2 (show CXCR2 Proteins) in tumor xenografts and gastric tissue adjacent to the tumor.

  7. data suggest that CXCR1 does not mediate the proliferative effects of ELR+ CXC chemokines during liver regeneration after partial hepatectomy

  8. CXCR1 expression is induced in hepatocytes after injury. Furthermore, the data suggest that CXCR1 has divergent effects from CXCR2 (show CXCR2 Proteins) and appears to facilitate repair and regenerative responses after I/R injury.

  9. CX3CL1 (show CX3CL1 Proteins)-CX3CR1 (show CX3CR1 Proteins) axis can regulate the expression of iNOS (show NOS2 Proteins), a crucial mediator of DSS (show PMP22 Proteins)-induced colitis.

  10. CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8 (show IL8 Proteins) in mouse

CXCR1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with CXCR1

  • interleukin 8 receptor, beta (CXCR2)
  • interleukin 8 receptor, alpha (IL8RA)
  • chemokine (C-X-C motif) receptor 1 (CXCR1)
  • chemokine (C-X-C motif) receptor 1 (Cxcr1)
  • chemokine (C-X-C motif) receptor 2 (CXCR2)
  • C-C protein
  • C-C-CKR-1 protein
  • CD128 protein
  • CD181 protein
  • CD182 protein
  • CDw128a protein
  • CDw128b protein
  • CKR-1 protein
  • CMKAR1 protein
  • CMKAR2 protein
  • CXCR-1 protein
  • CXCR1 protein
  • CXCR2 protein
  • IL-8RA protein
  • IL8R1 protein
  • IL8R2 protein
  • Il8ra protein
  • IL8RB protein
  • IL8RBA protein

Protein level used designations for CXCR1

C-X-C chemokine receptor type 2 , CXC-R2 , CXCR-2 , IL-8R B , high affinity interleukin-8 receptor B , interleukin 8 receptor, alpha , chemokine (C-X-C motif) receptor 1 , C-X-C chemokine receptor type 1 , CXC-R1 , CXCR-1 , IL-8 receptor type 1 , IL-8R A , high affinity interleukin-8 receptor A , interleukin-8 receptor type 1 , interleukin-8 receptor type A , CXC chemokine receptor 1 , chemokine (C-X-C motif) receptor 2 , interleukin 8 receptor, beta , chemokine (C-X-C) motif receptor 1 , chemokine (C-X-C) receptor 1 , interleukin 8 receptor alpha , IL-8 receptor , CXCR2 gene for IL8 receptor type B , GRO/MGSA receptor , IL-8 receptor type 2 , chemokine (CXC) receptor 2 , interleukin 8 receptor B , interleukin 8 receptor type 2 , interleukin-8 receptor type B

281863 Bos taurus
100127487 Sus scrofa
3577 Homo sapiens
227288 Mus musculus
478906 Canis lupus familiaris
100125580 Bos taurus
54258 Rattus norvegicus
100328622 Oryctolagus cuniculus
100461947 Pongo abelii
692074 Macaca mulatta
470645 Pan troglodytes
3579 Homo sapiens
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