Chordin Proteins (CHRD)

CHRD encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. Additionally we are shipping Chordin Antibodies (82) and Chordin Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHRD 8646 Q9H2X0
CHRD 12667 Q9Z0E2
Rat CHRD CHRD 117275  
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Top Chordin Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days

CHRD Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine) ,

More Proteins for Chordin (CHRD) Interaction Partners

Rabbit Chordin (CHRD) interaction partners

  1. Data show that BMP-2 (show BMP2 Proteins), BMP-4 (show BMP4 Proteins), and BMP-7 (show BMP7 Proteins), noggin (show NOG Proteins), and chordin were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.

Human Chordin (CHRD) interaction partners

  1. Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling.

  2. C-terminal chordin domains play an important role in Bone morphogenetic protein regulation.

  3. chordin silencing increased osteogenic differentiation without supplemented BMP-2 (show BMP2 Proteins).

  4. results suggest that CHRD could participate in regulating BMP activity in normal ovarian surface epithelium physiology, and that its mis (show AMH Proteins)-expression in ovarian surface epithelium may facilitate cancer incidence and/or progression

  5. Bone morphogenetic protein (BMP) chordin is produced endogenously during osteogenic differentiation of human mesenchymal stem cells (MSCs); blockade of bone morphogenetic inhibitor chordin increases the rate of osteogenic differentiation of MSCs in vitro.

  6. Noggin (show NOG Proteins) and chordin were also expressed most intensely in areas of cartilage formation and there was no difference in their expression between the non-hypertrophic and hypertrophic chondrocytes.

  7. there was no difference in the expression of the noggin (show NOG Proteins) and chordin between healing and nonhealing fractures

  8. Alternatively spliced variants have different patterns of expression to influence BMP activity in varying physiolgical situations.

Mouse (Murine) Chordin (CHRD) interaction partners

  1. Chordin upregulated in primary satellite cell cultures and in regenerating muscles

  2. The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes.

  3. Data show that Brorin-like was predominantly expressed in the adult brain and embryonic neural tissues.

  4. the BMP antagonists chordin and noggin (show NOG Proteins) promote the inductive and trophic activities of rostral organizing centers in early development of the mammalian head

  5. products of Bmp1 (show BMP1 Proteins) and Tll1 (show TLL1 Proteins) are responsible for in vivo cleavage of Chordin in mammals

  6. chordin antagonism of bone morphogenetic protein signaling and cellular uptake of chordin require cell-surface heparan sulfate proteoglycans

  7. results suggest that twisted gastrulation and chordin are involved in osteoblast differentiation and mineralization by regulating BMP signaling

  8. These results demonstrate that the chordin contributes to synaptic plasticity and learning likely through a presynaptic mechanism.

  9. chordin has a role in venous and arterial patterning and the Bone Morphogenetic Protein pathway is necessary for the process

  10. chordin is a modifier for the craniofacial anomalies of Tbx1 (show TBX1 Proteins) mutations.

Zebrafish Chordin (CHRD) interaction partners

  1. activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd and subsequent maintenance of dkk1b (show DKK1 Proteins) expression levels.

  2. Binding of CV2 (show BMPER Proteins) to Chordin promotes BMP-2 (show BMP4 Proteins) signaling.

  3. Targeted knockdown of Sox17 (show SOX17 Proteins) and Chd in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty (show LEFTY2 Proteins), and heart and pancreas placement in the embryo.

  4. Chl (show CHRDL2 Proteins), like Chd, dorsalizes embryos upon overexpression and is cleaved by BMP1 (show BMP1 Proteins); loss-of-function experiments show Chl (show CHRDL2 Proteins) serves as a BMP antagonist with functions that overlap and are redundant with those of Chd in forming the dorsoventral axis.

  5. Data show that The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development.

  6. by regulating the expression of her5, the Bmp2b (show BMP4 Proteins)/Chordin gradient directs the anteroposterior patterning of endoderm in zebrafish embryos

  7. chd, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.

  8. Twisted (show POMT2 Proteins) gastrulation enhances BMP signaling through chordin dependent and independent mechanisms

  9. specification of anterior neural tissue requires later activities of Chordin and mesodermal factors.

  10. While Chordin is the main player of the D/V axis, the structures remaining in the chd mutant in both mesodermal and ectodermal layers) result from the anti-Bmp activity carried by Nog1 (show NOG Proteins) and Fstl2 (show IGFBP7 Proteins) at blastula and gastrula stages.

Xenopus laevis Chordin (CHRD) interaction partners

  1. Chordin protein formed a smooth gradient that encircled the embryo, reaching the ventral-most Brachet cleft.

  2. This study demonstrates a crucial role of Sizzled in coupling dorsal-ventral axis size information with Chordin stability.

  3. Chordin, Noggin (show NOG Proteins), beta-Catenin (show CTNNB1 Proteins), and Cerberus (show CER1 Proteins) have roles in neural induction in Xenopus

  4. Bone morphogenetic protein 4 (show BMP4 Proteins) knockdown was sufficient to rescue the ventralizing effects caused by loss of Chordin activity.

  5. complex containing Smicl and the newly induced Xlim1 (show LHX1 Proteins) induces expression of Chordin

  6. Several lines of evidence support the hypothesis that chordin influences pronephros development by directing the formation of anterior somites.

  7. Embryo elongation can occur through the synergistic effect(s) of the organizer molecule chordin, and each of the 'verall posteriorizing molecules'eFGF, VegT and Xbra.

  8. Xld (show TLL2 Proteins) cleaves Chordin, an inhibitory binding protein for BMP2/4 (show BMP4 Proteins), releasing fragments with reduced affinity for these important ventralizing signals.

  9. CV2/Chordin interaction may help coordinate bone morphogenetic protein (BMP) diffusion to the ventral side of the embryo, ensuring that BMPs liberated from Chordin inhibition by tolloid proteolysis cause peak signaling levels.

  10. Study shows that Xenopus ONT1 (show OLFML3 Proteins), an Olfactomedin-class secreted protein, stabilizes axial formation by restricting Chordin activity on the dorsal side. [ONT1 (show OLFML3 Proteins)]

Chordin (CHRD) Protein Profile

Protein Summary

This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined.

Gene names and symbols associated with Chordin Proteins (CHRD)

  • chordin (CHRD)
  • chordin (CHD)
  • chordin (chrd)
  • chordin protein (chordin)
  • chordin (Chrd)
  • chordin (chd)
  • Chd protein
  • chordino protein
  • wu:fe47d04 protein
  • X-chordin protein

Protein level used designations for Chordin Proteins (CHRD)

chordin , chordin protein , din , dino (din) , fe47d04 , protein chordino , organizer-specific secreted-dorsalizing factor

100067164 Equus caballus
100008933 Oryctolagus cuniculus
395828 Gallus gallus
549011 Xenopus (Silurana) tropicalis
778563 Ciona intestinalis
8646 Homo sapiens
12667 Mus musculus
117275 Rattus norvegicus
30161 Danio rerio
607289 Canis lupus familiaris
509942 Bos taurus
398045 Xenopus laevis
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