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Claudin 18 Proteins (CLDN18)

CLDN18 encodes a member of the claudin family. Additionally we are shipping Claudin 18 Antibodies (60) and Claudin 18 Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLDN18 51208 P56856
CLDN18 56492 P56857
Rat CLDN18 CLDN18 315953  
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Top Claudin 18 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days

CLDN18 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Claudin 18 (CLDN18) Interaction Partners

Human Claudin 18 (CLDN18) interaction partners

  1. Data suggest that claudin-18 suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of pyruvate dehydrogenase kinase isoform 1 (PDK1 (show PDK1 Proteins)) and proto-oncogene (show RAB1A Proteins) protein c-akt (Akt (show AKT1 Proteins)).

  2. Human fetal lungs at 23-24 weeks gestational age, the highest-risk period for developing bronchopulmonary dysplasia, a disease of impaired alveolarization, had significantly lower CLDN18 expression relative to postnatal lungs.

  3. Evaluated expression of claudins in gastric cancer and determined their significance for patient outcome. Claudin-3 (show CLDN3 Proteins) and claudin-7 (show CLDN7 Proteins) were expressed in 25.4% and 29.9% of gastric cancer tissues; 51.5% of gastric cancer tissues had reduced claudin-18.

  4. High levels of CLDN18 are associated with non-small-cell lung cancer.

  5. Downregulation of miR (show MLXIP Proteins)-1303 can inhibit proliferation, migration and invasion of gastric cancer cells by targeting CLDN18.

  6. Claudin-18 positivity is a specific phenotype that is characteristic of intestinal-type Mucinous borderline tumours of the ovary

  7. Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer.

  8. Reduced expression of olfactomedin 4 (show OLFM4 Proteins) and ectopic expression of claudin-18 might be useful markers in the differential diagnosis of serrated polyps.

  9. Claudin 10 (show CLDN10 Proteins)/18 are most commonly expressed in lung adenocarcinomas. Female patients and non-smokers express these claudins more commonly suggesting that they may play a part in the carcinogenesis of tobacco unrelated carcinoma.

  10. Claudin 18 (a marker for early carcinogenesis) is commonly expressed in precursor lesions of pancreatic ductal adenocarcinomas. Activation of the protein kinase C pathway might be involved in claudin 18 expression associated with carcinogenesis.

Mouse (Murine) Claudin 18 (CLDN18) interaction partners

  1. CLDN18 deficiency results in epithelial barrier dysfunction, injury, and impaired alveolarization in mice.

  2. Identify a role for claudin 18 in alveolar fluid homeostasis beyond its direct contributions to barrier properties.

  3. we conclude that the estrogen effects on osteoclasts may in part be mediated via regulation of Cldn-18 signaling

  4. Claudin-18 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area.

  5. Cldn-18 is a novel negative regulator of bone resorption and osteoclast differentiation

  6. Claudin-18 forms a paracellular barrier against H(+) in the stomach. Deficiency causes paracellular H(+) leak, up-regulation of proinflammatory cytokines, recruitment of neutrophils, and atrophic gastritis.

  7. Increased expression of claudin-18 is associated with ulcerative colitis.

Claudin 18 (CLDN18) Protein Profile

Protein Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Claudin 18 Proteins (CLDN18)

  • claudin 18 (cldn18)
  • claudin 18 (CLDN18)
  • claudin 18 (LOC100349260)
  • claudin 18 (Cldn18)
  • claudin-18 protein
  • CLDN18 protein
  • SFTA5 protein
  • SFTPJ protein

Protein level used designations for Claudin 18 Proteins (CLDN18)

claudin 18 , claudin-18 , surfactant associated 5 , surfactant associated protein J , surfactant, pulmonary associated protein J , claudin 18-like

398928 Xenopus laevis
429135 Gallus gallus
470935 Pan troglodytes
716628 Macaca mulatta
100349260 Oryctolagus cuniculus
51208 Homo sapiens
477079 Canis lupus familiaris
100294676 Sus scrofa
511460 Bos taurus
56492 Mus musculus
315953 Rattus norvegicus
101112106 Ovis aries
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