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CCDC8 encodes a coiled-coil domain-containing protein. Additionally we are shipping Coiled-Coil Domain Containing 8 Antibodies (35) and Coiled-Coil Domain Containing 8 Kits (20) and many more products for this protein.
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CUL7, OBSL1 and CCDC8 modulate the alternative splicing of the INSR (show INSR Proteins)
The CUL7, OBSL1, and CCDC8 proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development.
Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.
discussion of roles of CCDC8, CUL7 (cullin 7), and OBSL1 (obscurin-like 1) in growth and development using findings from patients with Miller-McKusick-Malvaux syndrome and Silver-Russell syndrome [REVIEW]
p90 (show CANX Proteins) is a critical cofactor for p53 (show TP53 Proteins)-mediated apoptosis through promoting Tip60 (show KAT5 Proteins)-mediated p53 (show TP53 Proteins) acetylation.
We propose that CUL7, OBSL1, and CCDC8 are members of a pathway controlling mammalian growth.
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3).
coiled-coil domain-containing protein 8
, protein phosphatase 1, regulatory subunit 20
, probable Coiled-coil domain-containing protein 8
, coiled-coil domain-containing protein 8 homolog