Contactin Associated Protein-Like 2 Proteins (CNTNAP2)

CNTNAP2 encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. Additionally we are shipping CNTNAP2 Antibodies (57) and CNTNAP2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CNTNAP2 CNTNAP2 362355  
CNTNAP2 26047 Q9UHC6
CNTNAP2 66797 Q9CPW0
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Top CNTNAP2 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$437.80
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 70 to 75 Days
$9,050.32
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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CNTNAP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine) ,
,

Top referenced CNTNAP2 Proteins

  1. Mouse (Murine) CNTNAP2 Protein expressed in Human Cells - ABIN2008100 : Verkerk, Mathews, Joosse, Eussen, Heutink, Oostra: CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. in Genomics 2003 (PubMed)

More Proteins for Contactin Associated Protein-Like 2 (CNTNAP2) Interaction Partners

Human Contactin Associated Protein-Like 2 (CNTNAP2) interaction partners

  1. Bi-allelic aberrations (mutations and copy number variants) in CNTNAP2 in eight individuals with intellectual disability and epilepsy were reported.

  2. Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2-IgG or LGI1 (show LGI1 Proteins)-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1 (show LGI1 Proteins)-IgG.

  3. Caspr2 antibodies associate with a treatable disorder that predominantly affects elderly men. The resulting syndrome may vary among patients but it usually includes a set of well-established symptoms.

  4. The molecular shape and dimensions of CNTNAP2 place constraints on how CNTNAP2 integrates in the cleft of axo (show MARCH7 Proteins)-glial and neuronal contact sites and how it functions as an organizing and adhesive molecule.

  5. A significant association was found between rs7794745 CNTNAP2 gene polymorphism and autism in an Iranian population.

  6. rs7794745 in the CNTNAP2 gene was associated with autistic spectrum disorder in Brazilian patients.

  7. we could not detect any significant association with the CNTNAP2 gene and high functioning autism

  8. CNTNAP2 is transcriptionally regulated by FOXP2 (show FOXP2 Proteins).

  9. Structurally, CASPR2 is highly glycosylated and has an overall compact architecture. CASPR2 associates with micromolar affinity with CNTN1 (show CNTN1 Proteins) but, under the same conditions, it does not interact with any of the other members of the contactin family.

  10. Results indicate that the CNTNAP2 gene may confer vulnerability to speech sound disorder

Mouse (Murine) Contactin Associated Protein-Like 2 (CNTNAP2) interaction partners

  1. After middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs. In addition, there is suppression of the language-associated transcription factor,contactin-associated protein 2 (Cntnap2).

  2. Olfaction-based behavioral tests revealed that mice lacking Caspr2 exhibit abnormal response to sensory stimuli and lack preference for novel odors.

  3. Mice with the Cntnap2 genetic mutation showed a dissociation of auditory-processing abilities

  4. Study reports behavioral characterization of mouse models of autism with null mutation in Cntnap2 gene. It shows hyperactivity, mild gait phenotype and reduced vocalizations among others.

  5. new dendritic spines in mice lacking CNTNAP2 were formed at normal rates, but failed to stabilize. Notably, rates of spine elimination were unaltered, suggesting a specific role for CNTNAP2 in stabilizing new synaptic circuitry

  6. Cntnap2 deletion selectively impairs perisomatic hippocampal inhibition while sparing excitation provide additional support for synaptic dysfunction as a common mechanism underlying autism spectrum disorders

  7. The CASPR2/MUPP1 receptor complex co-localized with GPR37 (show GPR37 Proteins) in hippocampal neurons.

  8. Interaction proteomics revealed the interactors of Caspr2, including CNTN2 (show CNTN2 Proteins), KCNAs, members of the ADAM family (ADAM22 (show ADAM22 Proteins), ADAM23 (show Adam23 Proteins) and ADAM11 (show ADAM11 Proteins)), members of LGI family and MAGUKs (DLGs and MPPs (show MPHOSPH6 Proteins)).

  9. CNTNAP2 has a role in the correct trafficking of GluA1 (show GRIA1 Proteins) AMPA (show GRIA3 Proteins)-type glutamate (show GRIN1 Proteins) receptors

  10. Caspr2 is required for paranodal clustering of Kv1 (show KCNA5 Proteins) channels in the absence of Caspr (show CNTNAP1 Proteins). Absence of both Caspr (show CNTNAP1 Proteins) and Caspr2 results in the widening of the nodes of Ranvier.

CNTNAP2 Protein Profile

Protein Summary

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.

Gene names and symbols associated with CNTNAP2

  • contactin associated protein-like 2 (CNTNAP2)
  • contactin associated protein-like 2 (cntnap2)
  • contactin associated protein-like 2 (Cntnap2)
  • 5430425M22Rik protein
  • AUTS15 protein
  • CASPR protein
  • Caspr2 protein
  • CDFE protein
  • MGC145769 protein
  • MGC147944 protein
  • MGC147981 protein
  • mKIAA0868 protein
  • NRXN4 protein
  • PTHSL1 protein

Protein level used designations for CNTNAP2

cell recognition molecule Caspr2 , contactin associated protein-like 2 , novel protein similar to H.sapiens contactin associated protein , contactin associated protein 2 , contactin-associated protein-like 2 , contactin-associated protein-like 2-like , homolog of Drosophila neurexin IV

GENE ID SPECIES
463819 Pan troglodytes
516395 Bos taurus
563345 Danio rerio
574172 Macaca mulatta
780189 Xenopus (Silurana) tropicalis
100174321 Pongo abelii
362355 Rattus norvegicus
100013863 Monodelphis domestica
100060296 Equus caballus
100073864 Ornithorhynchus anatinus
100223892 Taeniopygia guttata
100354524 Oryctolagus cuniculus
100397041 Callithrix jacchus
100607262 Nomascus leucogenys
26047 Homo sapiens
66797 Mus musculus
500105 Rattus norvegicus
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