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Cullin 2 Proteins (CUL2)

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. Additionally we are shipping Cullin 2 Antibodies (129) and Cullin 2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CUL2 8453 Q13617
CUL2 71745 Q9D4H8
Rat CUL2 CUL2 361258  
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Top Cullin 2 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

CUL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Cullin 2 (CUL2) Interaction Partners

Human Cullin 2 (CUL2) interaction partners

  1. misfolded TDP-43 (show TARDBP Proteins) is cleared by VHL (show VHL Proteins)/CUL2 in a step-wise manner via fragmentation.

  2. Cullins are a family of NEDD8 (show NEDD8 Proteins) targets important in the stabilization and degradation of proteins, such as hypoxia-inducible factor (HIF1A (show HIF1A Proteins)), via Cullin-2.

  3. Nevertheless, the identification of the Cul2 box may allow prediction of Cullin specificity for all E4orf6-containing Adenoviridae.

  4. a novel link between the oncoprotein PRAME and the conserved EKC complex

  5. Study finds that UBXN7 over-expression converts CUL2 to its neddylated form and causes the accumulation of non-ubiquitylated HIF1alpha (show HIF1A Proteins).

  6. The authors applied protein-complex purification strategies and identified PRAME (show PRAME Proteins) as a substrate recognition subunit of a Cullin2-based E3 ubiquitin ligase (show MUL1 Proteins).

  7. The data suggest that neither HIF1alpha (show HIF1A Proteins) nor CUL2 mutation may play a central role in HIF1alpha (show HIF1A Proteins) activation in gastric, colorectal, breast, lung and hepatocellular carcinomas, and acute leukemias.

  8. Cullin selection is determined by specific Elongin C (show TCEB1 Proteins) and Skp1 (show SKP1 Proteins) sequences

  9. the HPV16 E7-associated cullin 2 ubiquitin ligase complex contributes to aberrant degradation of the pRB (show RB1 Proteins) tumor suppressor in HPV16 E7-expressing cells.

  10. CUL2 is required for normal vasculogenesis, at least in part mediated by its regulation of HIF-mediated transcription.

Cow (Bovine) Cullin 2 (CUL2) interaction partners

  1. Authors show that bovine immunodeficiency virus Vif (show BTG1 Proteins) interacts with Cullin 2 (CUL2), ELOB (show TCEB2 Proteins)/C, and RBX1 (show RBX1 Proteins), but not with CBF-beta (show CBFB Proteins) or CUL5 (show CUL5 Proteins), to form a CRL2 (show DAND5 Proteins) E3 ubiquitin ligase (show MUL1 Proteins) and degrade the restrictive bovine APOBEC3 (show APOBEC3F Proteins) proteins (A3Z2Z3 and A3Z3 (show APOBEC3F Proteins)).

Caenorhabditis elegans (C. elegans) Cullin 2 (CUL2) interaction partners

  1. CUL-2 RING E3 ubiquitin-ligase (show MUL1 Proteins) acts at multiple levels to control germline development; CUL-2 may similarly regulate germline development in other organisms as well.

  2. Results indicate that LRR-1 (show LRR1 Proteins) acts as a nuclear substrate-recognition subunit of a Cullin 2-RING E3 ligase complex (CRL2 (show DAND5 Proteins)(LRR-1 (show LRR1 Proteins))), which ensures DNA replication integrity.

  3. The C. elegans p97/CDC-48 (show vcp Proteins)-UFD-1 (show UFD1L Proteins)-NPL-4 complex controls the sperm-oocyte switch by regulating CUL-2-mediated TRA-1A proteasome degradation.

  4. segregation of the germ plasm involves both stabilization of germline proteins in the germ line and cullin-dependent degradation in the soma

  5. Results establish that zyg-11 and the cullin cul-2 promote the metaphase-to-anaphase transition and M phase exit at meiosis II in Caenorhabditis elegans.

  6. Data show that inactivation of ZYG-11 produces meiotic and polarity reversal defects similar to those observed in CUL-2 mutants, suggesting that the two proteins function in the same pathways.

  7. oocyte maturation from pachytene exit and MPK-1 (show MAPK1 Proteins) activation are redundantly controlled by the RBX-2-CUL-5 (show CUL5 Proteins)- and RBX-1 (show RBX1 Proteins)-CUL-2-based complexes.

  8. TRA-1 is regulated by degradation mediated by a CUL-2-based ubiquitin ligase complex

  9. Fem-1 protein is a substrate-specific adaptor for a CUL-2-based ubiquitin ligase.

  10. MEL-26 levels are kept low by the action of another type of ubiquitin ligase, which contains CUL-2

Cullin 2 (CUL2) Protein Profile

Protein Summary

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

Gene names and symbols associated with Cullin 2 Proteins (CUL2)

  • Cullin-2 (cul2)
  • cullin 2 (CUL2)
  • cullin-2 (PTRG_05231)
  • cullin-2 (cul-2) (Smp_079740)
  • cullin 2 (cul2)
  • cullin 2 (LOC100221330)
  • cullin 2 (Cul2)
  • Protein CUL-2 (cul-2)
  • 1300003D18Rik protein
  • 4932411N15Rik protein
  • AI327301 protein
  • ATCUL2 protein
  • cul2 protein
  • cullin-2 protein
  • cullin 2 protein
  • F22D16.2 protein
  • F22D16_2 protein
  • fj48a06 protein
  • LOC100221330 protein
  • mKIAA4106 protein
  • wu:fj48a06 protein

Protein level used designations for Cullin 2 Proteins (CUL2)

Cullin-2 , CUL-2 , cullin-2 , cullin-2 (cul-2) , cullin 2 , cullin-2-like

100195615 Salmo salar
100174361 Pongo abelii
6343481 Pyrenophora tritici-repentis Pt-1C-BFP
8345692 Schistosoma mansoni
336088 Danio rerio
420467 Gallus gallus
450399 Pan troglodytes
698384 Macaca mulatta
100221330 Taeniopygia guttata
100395340 Callithrix jacchus
100550749 Meleagris gallopavo
8453 Homo sapiens
71745 Mus musculus
361258 Rattus norvegicus
477952 Canis lupus familiaris
535219 Bos taurus
379729 Xenopus laevis
839415 Arabidopsis thaliana
176806 Caenorhabditis elegans
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