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CUL3 encodes a member of the cullin protein family. Additionally we are shipping Cullin 3 Kits (9) and Cullin 3 Proteins (6) and many more products for this protein.
Showing 10 out of 92 products:
Human Polyclonal Cullin 3 Primary Antibody for EIA, IHC (p) - ABIN117949
Furukawa, He, Borchers, Xiong: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. in Nature cell biology 2003
Show all 9 references for ABIN117949
Chicken Monoclonal Cullin 3 Primary Antibody for IF, WB - ABIN968679
Hori, Osaka, Chiba, Miyamoto, Okabayashi, Shimbara, Kato, Tanaka: Covalent modification of all members of human cullin family proteins by NEDD8. in Oncogene 2000
Show all 2 references for ABIN968679
Human Polyclonal Cullin 3 Primary Antibody for IP, WB - ABIN233772
Shiraishi, Zhou, Aoki, Sato, Chiba, Tanaka, Yoshida, Nabeshima, Nabeshima, Tamura: TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. in The Journal of biological chemistry 2007
Human Polyclonal Cullin 3 Primary Antibody for IF (p), IHC (p) - ABIN705296
Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015
Human Polyclonal Cullin 3 Primary Antibody for ICC, IF - ABIN188779
Li, Ao, Fu, Lee, Xu, Lonard, OMalley: Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. in Oncogene 2011
Data show that CUL3 and BPM proteins assemble in planta with WRI1.
The plasma membrane-associated phototropic receptor phot1 is ubiquitinated in response to blue light activation. Ubiquitination of phot1 is dependent upon both the phot1-interacting proteins NPH3 and CUL3.
AtCUL3a and AtCUL3b can assemble in Arabidopsis with BTB/POZ-MATH and AtRBX1 proteins to form functional E3 ligases. [AtCUL3a]
CUL3A is ubiquitously expressed in plants and is able to interact with the ring-finger protein (show TRIM31 Antibodies) RBX1 (show RBX1 Antibodies). [CUL3A]
Arabidopsis CUL3A gene is essential for normal embryogenesis.
work highlights that CUL3 is essential for the normal division and organisation of the root stem cell niche and columella root cap cells
CUL3a and CUL3b are essential for plant development [CUL3a]
Data show that Cullin3 exerts its function through promoting breast-cancer metastasis suppressor 1 (BRMS1 (show BRMS1 Antibodies)) protein degradation, which was associated with epithelial-mesenchymal transition (EMT (show ITK Antibodies)), migration and invasion.
CUL3 acts as a tumor suppressor by regulating oxidative stress
The authors find that the KCTD proteins 5, 6, 9 and 17 bind to Cul3 with high affinity, while the KCTD proteins 1 and 16 do not have detectable binding.
Study identifies a key role of Cul3-KLHL20 (show KLHL20 Antibodies) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Antibodies) and VPS34 (show PIK3C3 Antibodies) complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.
Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1 (show CAND1 Antibodies)), COP9 (show COPS8 Antibodies) signalosome (CSN), neddylated cullin 3 (Cul3) and the BTB protein Keap1 (show KEAP1 Antibodies).
Heterodimeric CUL3 proteinubiquitylates TIAM1.CUL3 regulates TIAM1 abundance and subsequent RAC1 signaling.
these findings indicate that the designed stapled peptides can efficiently mimic protein-protein interactions and are potentially able to modulate fundamental biological processes involving Cul3.
these results suggest an essential role for CUL3 in the invasion and migration of trophoblast cells, and dysregulation of its expression may be associated with the onset of pre-eclampsia
The KCTD5/cullin3 complex stabilizes ZNF711 transcription factor.Formation of trimeric complexes of KCTD5/cullin3 with MCM7, ZNF711 and FAM193B.
Cul3 deletion mutations (associated with hypertension), impair ubiquitin ligase activity toward RhoA (show RHOA Antibodies).
Suggest that the hyperkalemia in knock-in mouse with the CUL3(Delta403-459) mutation is not caused by reduced ROMK (show KCNJ1 Antibodies) expression in the distal nephron.
These results suggest that KLHL2 (show KLHL2 Antibodies) likely plays a role in the pathogenesis of FHHt, and aggravates the phenotype caused by mutations in CUL3 and WNK4 (show WNK4 Antibodies).
Hypoxia-responsive miR (show MLXIP Antibodies)-101 stimulates angiogenesis by activating the HO-1 (show HMOX1 Antibodies)/VEGF (show VEGFA Antibodies)/eNOS (show NOS3 Antibodies) axis via Cul3 targeting
Mutation of cul3 protein is involved in the development of renal hypertension and chronic kidney diseases.
Data show that Bcl6 (show BCL6 Antibodies) (B cell lymphoma 6)-cullin 3 complexes provide essential negative feedback regulation during both thymocyte development and T cell activation to restrain excessive T follicular helper (Tfh) responses.
the early or pre-induction nuclear export of INrf2 (show KEAP1 Antibodies) in response to antioxidants is controlled by tyrosine phosphorylation, whereas the nuclear export of Cul3 and Rbx1 is controlled by INrf2 (show KEAP1 Antibodies), allowing normal activation or repression of Nrf2 (show NFE2L2 Antibodies)
Knockdown of Cullin-3 or inhibition of cullin-RING ligase activity in aortic smooth muscle cells increased RhoA (show RHOA Antibodies).
CUL3 deletion in mice demonstrated an essential role for CUL3 in the development of PLZF (show ZBTB16 Antibodies)- and BCL6 (show BCL6 Antibodies)-dependent lineages; distinct lineage-specific BTB-ZF transcription factors recruit CUL3 to alter the ubiquitination pattern of their associated chromatin-modifying complex
The authors identified MUF1 as the first substrate for RhoBTB-Cul3 ubiquitin ligase complexes.
KEL-8 is a substrate receptor for Cullin 3 ubiquitin ligases that is required for the proteolysis of GLR-1 receptors and suggest a novel postmitotic role in neurons for Kelch/CUL3 ubiquitin ligases.
The BTB-containing protein MEL-26 is a component required for degradation of MEI-1 (show MEI1 Antibodies) in vivo; importantly, MEL-26 specifically interacts with CUL-3 and MEI-1 (show MEI1 Antibodies) in vivo and in vitro, and displays properties of a substrate-specific adaptor
the identification of a large family of BTB-domain proteins as substrate-specific adaptors for C. elegans CUL-3
FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis.
cullin (CUL)-3 as a component of E3 ligase and KEL-8 as the substrate adaptor of RPY-1.
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, Cullin-3 (CUL-3)
, cullin 3