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anti-Cullin 3 (CUL3) Antibodies

CUL3 encodes a member of the cullin protein family. Additionally we are shipping Cullin 3 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CUL3 8452 Q13618
CUL3 26554 Q9JLV5
CUL3 301555  
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Top anti-Cullin 3 Antibodies at

Showing 10 out of 94 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), IP, WB Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs). Most modifiers mature by proteolytic processing from inactive precursors (a, amino acid). Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugation requires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUB involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin-2/elongin B/elonginC) -like E3 enzymes that are also involved in ubiquitination. In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked head-to-tail. Whether HUB1 functions as a modifier is currently unclear. APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin. Data contributed by S.Jentsch, see references below. 0.1 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Western Blot: Cul3 Antibody [ABIN188779] - Detection of Human Cul3 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Cul3 antibody ABIN188779 used for IP at 3 mcg/mg lysate. Cul3 was also immunoprecipitated by other rabbit anti-Cul3 antibodies ABIN188778, which recognize downstream epitopes.  Detection: Chemiluminescence with an exposure time of 10 seconds. Immunohistochemistry-Paraffin: Cullin 3 Antibody [ABIN1887798] - Human breast carcinoma. Antibody used at a dilution of1:200 (1ug/ml). 0.1 mL Log in to see 5 to 7 Days
Chicken Mouse Un-conjugated IF, WB Western blot analysis of CUL-3 on a rat cerebrum lysate. Lane 1: 1:10,000, lane 2: 1:20,000, lane 3: 1:40,000 dilution of the mouse anti- CUL-3 antibody. Immunofluorescence staining of human endothelial cells. 50 μg Log in to see 5 to 6 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 This image was generously provided by Yang Song, Ph.D. at Southwest University in Chong Qing, China. HepG2 cells were incubated with Rabbit Anti-Cullin 3 Polyclonal Antibody  at 4°C overnight and then mixed with Protein A agarose beads at 4°C for 3hrs. The solutions were centrifuged and the pellets were washed with lysis buffer, heated, and subsequently analyzed by Western blotting. 100 μL Log in to see 3 to 7 Days
Human Rabbit Un-conjugated IP, WB Anti-CUL3 antibody was diluted 1:500 to detect CUL3 in human breast tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry with Testis tissue at an antibody concentration of 10µg/ml using anti-CUL3 antibody (ARP61264_P050) 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB WB Image Cullin 3 antibody detects Cullin 3 protein by Western blot analysis. A. 30 µg 293T whole cell lysate/extract B. 30 µg whole cell lysate/extract of human CUL3-transfected 293T cells 7.5 % SDS-PAGE Cullin 3 antibody , dilution: 1:5000 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue, using Cullin 3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB Anti-Cullin3 antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: MCF-7 Cell Lysate Lane 3: Rat Testis Tissue Lysate Lane 4: Rat Brain Tissue Lysate 100 μg Log in to see 4 to 6 Days
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Cullin 3 staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Cullin 3 expression in MDAMB231 (A), MDAMB468 (B), NIH3T3 (C), PC12 (D) whole cell lysates. 200 μL Log in to see 9 Days

CUL3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Cullin 3 Antibodies

  1. Human Polyclonal Cullin 3 Primary Antibody for EIA, IHC (p) - ABIN117949 : Furukawa, He, Borchers, Xiong: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. in Nature cell biology 2003 (PubMed)
    Show all 9 references for ABIN117949

  2. Human Polyclonal Cullin 3 Primary Antibody for ICC, IF - ABIN188779 : Li, Ao, Fu, Lee, Xu, Lonard, OMalley: Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. in Oncogene 2011 (PubMed)
    Show all 2 references for ABIN188779

  3. Chicken Monoclonal Cullin 3 Primary Antibody for IF, WB - ABIN968679 : Hori, Osaka, Chiba, Miyamoto, Okabayashi, Shimbara, Kato, Tanaka: Covalent modification of all members of human cullin family proteins by NEDD8. in Oncogene 2000 (PubMed)
    Show all 2 references for ABIN968679

  4. Human Polyclonal Cullin 3 Primary Antibody for IP, WB - ABIN233772 : Shiraishi, Zhou, Aoki, Sato, Chiba, Tanaka, Yoshida, Nabeshima, Nabeshima, Tamura: TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. in The Journal of biological chemistry 2007 (PubMed)

  5. Human Polyclonal Cullin 3 Primary Antibody for IF (p), IHC (p) - ABIN705296 : Su, Zhang, Song, Shi, Fu, Xia, Bai, Hu, Xu, Song, Song: Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation. in Chemical research in toxicology 2015 (PubMed)

More Antibodies against Cullin 3 Interaction Partners

Arabidopsis thaliana Cullin 3 (CUL3) interaction partners

  1. Data show that CUL3 and BPM proteins assemble in planta with WRI1.

  2. The plasma membrane-associated phototropic receptor phot1 is ubiquitinated in response to blue light activation. Ubiquitination of phot1 is dependent upon both the phot1-interacting proteins NPH3 and CUL3.

  3. AtCUL3a and AtCUL3b can assemble in Arabidopsis with BTB/POZ-MATH and AtRBX1 proteins to form functional E3 ligases. [AtCUL3a]

  4. CUL3A is ubiquitously expressed in plants and is able to interact with the ring-finger protein (show TRIM31 Antibodies) RBX1 (show RBX1 Antibodies). [CUL3A]

  5. Arabidopsis CUL3A gene is essential for normal embryogenesis.

  6. work highlights that CUL3 is essential for the normal division and organisation of the root stem cell niche and columella root cap cells

  7. CUL3a and CUL3b are essential for plant development [CUL3a]

Human Cullin 3 (CUL3) interaction partners

  1. Together, the data indicate that a CUL3-SPOPL (show SPOPL Antibodies) E3 ubiquitin ligase (show MUL1 Antibodies) complex regulates endocytic trafficking and formation of multivesicular bodies by ubiquitinating and degrading EPS15 (show EPS15 Antibodies) at endosomes.

  2. Data show that Cullin3 exerts its function through promoting breast-cancer metastasis suppressor 1 (BRMS1 (show BRMS1 Antibodies)) protein degradation, which was associated with epithelial-mesenchymal transition (EMT (show ITK Antibodies)), migration and invasion.

  3. CUL3 acts as a tumor suppressor by regulating oxidative stress

  4. The authors find that the KCTD proteins 5, 6, 9 and 17 bind to Cul3 with high affinity, while the KCTD proteins 1 and 16 do not have detectable binding.

  5. Study identifies a key role of Cul3-KLHL20 (show KLHL20 Antibodies) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Antibodies) and VPS34 (show PIK3C3 Antibodies) complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.

  6. Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1 (show CAND1 Antibodies)), COP9 (show COPS8 Antibodies) signalosome (CSN), neddylated cullin 3 (Cul3) and the BTB protein Keap1 (show KEAP1 Antibodies).

  7. Heterodimeric CUL3 proteinubiquitylates TIAM1.CUL3 regulates TIAM1 abundance and subsequent RAC1 signaling.

  8. these findings indicate that the designed stapled peptides can efficiently mimic protein-protein interactions and are potentially able to modulate fundamental biological processes involving Cul3.

  9. these results suggest an essential role for CUL3 in the invasion and migration of trophoblast cells, and dysregulation of its expression may be associated with the onset of pre-eclampsia

  10. The KCTD5/cullin3 complex stabilizes ZNF711 transcription factor.Formation of trimeric complexes of KCTD5/cullin3 with MCM7, ZNF711 and FAM193B.

Mouse (Murine) Cullin 3 (CUL3) interaction partners

  1. Suggest that the hyperkalemia in knock-in mouse with the CUL3(Delta403-459) mutation is not caused by reduced ROMK (show KCNJ1 Antibodies) expression in the distal nephron.

  2. Study identifies a key role of Cul3-KLHL20 (show KLHL20 Antibodies) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Antibodies) and VPS34 (show PIK3C3 Antibodies) complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.

  3. These results suggest that KLHL2 (show KLHL2 Antibodies) likely plays a role in the pathogenesis of FHHt, and aggravates the phenotype caused by mutations in CUL3 and WNK4 (show WNK4 Antibodies).

  4. Hypoxia-responsive miR (show MLXIP Antibodies)-101 stimulates angiogenesis by activating the HO-1 (show HMOX1 Antibodies)/VEGF (show VEGFA Antibodies)/eNOS (show NOS3 Antibodies) axis via Cul3 targeting

  5. Mutation of cul3 protein is involved in the development of renal hypertension and chronic kidney diseases.

  6. Data show that Bcl6 (show BCL6 Antibodies) (B cell lymphoma 6)-cullin 3 complexes provide essential negative feedback regulation during both thymocyte development and T cell activation to restrain excessive T follicular helper (Tfh) responses.

  7. the early or pre-induction nuclear export of INrf2 (show KEAP1 Antibodies) in response to antioxidants is controlled by tyrosine phosphorylation, whereas the nuclear export of Cul3 and Rbx1 is controlled by INrf2 (show KEAP1 Antibodies), allowing normal activation or repression of Nrf2 (show NFE2L2 Antibodies)

  8. Knockdown of Cullin-3 or inhibition of cullin-RING ligase activity in aortic smooth muscle cells increased RhoA (show RHOA Antibodies).

  9. CUL3 deletion in mice demonstrated an essential role for CUL3 in the development of PLZF (show ZBTB16 Antibodies)- and BCL6 (show BCL6 Antibodies)-dependent lineages; distinct lineage-specific BTB-ZF transcription factors recruit CUL3 to alter the ubiquitination pattern of their associated chromatin-modifying complex

  10. The authors identified MUF1 as the first substrate for RhoBTB-Cul3 ubiquitin ligase complexes.

Caenorhabditis elegans (C. elegans) Cullin 3 (CUL3) interaction partners

  1. KEL-8 is a substrate receptor for Cullin 3 ubiquitin ligases that is required for the proteolysis of GLR-1 receptors and suggest a novel postmitotic role in neurons for Kelch/CUL3 ubiquitin ligases.

  2. The BTB-containing protein MEL-26 is a component required for degradation of MEI-1 (show MEI1 Antibodies) in vivo; importantly, MEL-26 specifically interacts with CUL-3 and MEI-1 (show MEI1 Antibodies) in vivo and in vitro, and displays properties of a substrate-specific adaptor

  3. the identification of a large family of BTB-domain proteins as substrate-specific adaptors for C. elegans CUL-3

  4. FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis.

  5. cullin (CUL)-3 as a component of E3 ligase and KEL-8 as the substrate adaptor of RPY-1.

Cullin 3 (CUL3) Antigen Profile

Protein Summary

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with anti-Cullin 3 (CUL3) Antibodies

  • cullin 3 (CUL3) antibody
  • cullin 3 (cul3) antibody
  • cullin 3 (cul3-a) antibody
  • cullin 3 (cul3-b) antibody
  • cullin-3 (PTRG_11586) antibody
  • Cullin-3 (CUL-3) (Smp_117580) antibody
  • cullin 3a (cul3a) antibody
  • cullin 3 (Cul3) antibody
  • Protein CUL-3 (cul-3) antibody
  • AI467304 antibody
  • ATCUL3 antibody
  • ATCUL3A antibody
  • AW146203 antibody
  • CUL-3 antibody
  • CUL-3-A antibody
  • CUL-3-B antibody
  • CUL3 antibody
  • CUL3A antibody
  • cul3b antibody
  • Cullin-3 antibody
  • Cullin-3-A antibody
  • Cullin-3-B antibody
  • cullin 3 antibody
  • cullin 3A antibody
  • mKIAA0617 antibody
  • PHA2E antibody
  • T24P13.25 antibody
  • wu:fc37e01 antibody

Protein level used designations for anti-Cullin 3 (CUL3) Antibodies

cullin-3 , cullin-3-A , cullin-3-B , Cullin-3 (CUL-3) , cullin 3 , CUL-3

100061420 Equus caballus
548729 Xenopus (Silurana) tropicalis
446487 Xenopus laevis
444103 Xenopus laevis
6349903 Pyrenophora tritici-repentis Pt-1C-BFP
8349090 Schistosoma mansoni
324655 Danio rerio
744812 Pan troglodytes
839226 Arabidopsis thaliana
8452 Homo sapiens
26554 Mus musculus
301555 Rattus norvegicus
424804 Gallus gallus
477392 Canis lupus familiaris
534325 Bos taurus
178547 Caenorhabditis elegans
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