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anti-Cullin 7 (CUL7) Antibodies

The protein encoded by CUL7 is a component of an E3 ubiquitin-protein ligase complex. Additionally we are shipping Cullin 7 Kits (9) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CUL7 9820 Q14999
CUL7 66515 Q8VE73
CUL7 363191  
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Top anti-Cullin 7 Antibodies at

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), IP, WB Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs). Most modifiers mature by proteolytic processing from inactive precursors (a, amino acid). Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugation requires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUB involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin-2/elongin B/elonginC) -like E3 enzymes that are also involved in ubiquitination. In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked head-to-tail. Whether HUB1 functions as a modifier is currently unclear. APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin. Data contributed by S.Jentsch, see references below. 0.1 mL Log in to see 6 to 8 Days
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged CUL7 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
Human Rabbit Un-conjugated IHC (p), IP, ELISA, WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with CUL7 antibody ABIN218511 at 1:500 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated IP, IHC, ELISA, WB 0.05 mL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IP, WB Anti-CUL7 antibody was diluted 1:500 to detect CUL7 in human brain cortex tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ICC, IHC (p), WB   100 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of methanol-fixed HeLa, using Cullin 7, antibody at 1:200 dilution. WB Image Sample (30 ug of whole cell lysate) A: Molt-4 , 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days

CUL7 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) , ,

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Top referenced anti-Cullin 7 Antibodies

  1. Human Polyclonal Cullin 7 Primary Antibody for EIA, IHC (p) - ABIN117952 : Chen, Ma, Gao, Wang, Zhao, Wu, Wang, Xie, OuYang, Luo, Guo, Han, Liu, Wang: The active ingredients of Jiang-Zhi-Ning: study of the Nelumbo nucifera alkaloids and their main bioactive metabolites. in Molecules (Basel, Switzerland) 2012 (PubMed)
    Show all 4 references for ABIN117952

More Antibodies against Cullin 7 Interaction Partners

Human Cullin 7 (CUL7) interaction partners

  1. study provided evidence that Cullin7 functions as a novel oncogene (show RAB1A Antibodies) in breast cancer and may be a potential therapeutic target for breast cancer management

  2. CUL7, OBSL1 and CCDC8 (show CCDC8 Antibodies) modulate the alternative splicing of the INSR (show INSR Antibodies)

  3. The CUL7, OBSL1, and CCDC8 (show CCDC8 Antibodies) proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development.

  4. CUL7/Fbxw8 (show FBXW8 Antibodies) ubiquitin ligase-mediated HPK1 (show MAP4K1 Antibodies) degradation revealed a direct link and novel role of CUL7/Fbxw8 (show FBXW8 Antibodies) ubiquitin ligase in the MAPK (show MAPK1 Antibodies) pathway, which plays a critical role in cell proliferation and differentiation.

  5. Homozygous deletion in exon 18 of the CUL7 gene, which has not been previously described, could be responsible for the 3-M syndrome.

  6. This study demonstrates specific genomic alterations in HCC (show FAM126A Antibodies)/MS and points to CUL7 as a novel gene potentially involved in liver carcinogenesis associated with metabolic Syndrome, the amplification of which might influence cell proliferation.

  7. Dysregulation of Cul7 and Fbxw8 (show FBXW8 Antibodies) expression might affect trophoblast turnover in intrauterine growth restriction.

  8. Mutations in CUL7, OBSL1 and CCDC8 (show CCDC8 Antibodies) in 3-M syndrome lead to disordered growth factor signalling.

  9. Growth factor-stimulated TBC1D3 (show TBC1D3 Antibodies) ubiquitination and degradation are regulated by its interaction with CUL7-Fbw8 (show FBXW8 Antibodies).

  10. discussion of roles of CUL7, OBSL1 (obscurin-like 1), and CCDC8 (coiled-coil domain containing protein 8 (show CCDC8 Antibodies)) in growth and development using findings from patients with Miller-McKusick-Malvaux syndrome and Silver-Russell syndrome [REVIEW]

Mouse (Murine) Cullin 7 (CUL7) interaction partners

  1. Cul7-/- mouse embryonic fibroblasts displayed an increase in the activation of AKT (show AKT1 Antibodies) and Erk (show EPHB2 Antibodies) phosphorylation upon insulin (show INS Antibodies) stimulation.

  2. role of binding of Cul7 to simian virus 40 large T antigen in cell transformation; may also regulate an important growth control pathway

  3. Antagonization of p193 and p53 (show TP53 Antibodies) activity relaxes the otherwise stringent regulation of cardiomyocyte cell cycle reentry in the injured adult heart.

  4. Dimerization o Cul7 and Parc (show CUL9 Antibodies) is not required for all Cul7 functions and mouse embryonic development.

  5. Cul7 forms a heterodimeric complex with Cul1 (show CUL1 Antibodies) in a manner dependent on Fbxw8 (show FBXW8 Antibodies).

  6. suggested a role for p193/CUL7 in the regulation of apoptosis independently of p53 (show TP53 Antibodies) and Parc (show CUL9 Antibodies) activity

  7. Results demonstrate a key role for the CUL7 E3 in targeting IRS-1 (show IRS1 Antibodies) for degradation, a process that may contribute to the regulation of cellular senescence.

  8. Expression of the dominant interfering p193 transgene results in a decrease in infarct scar expansion and preservation of myocardial function at 4 weeks after Myocardial Infarction.

Cullin 7 (CUL7) Antigen Profile

Protein Summary

The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Cullin 7 (CUL7) Antibodies

  • cullin 7 (CUL7) antibody
  • cullin 7 (CH242-196P11.12) antibody
  • cullin 7 (Cul7) antibody
  • 2510004L20Rik antibody
  • AA409809 antibody
  • C230011P08Rik antibody
  • CUL7 antibody
  • Cullin-7 antibody
  • dJ20C7.5 antibody
  • KIAA0076 antibody
  • p185 antibody
  • p193 antibody

Protein level used designations for anti-Cullin 7 (CUL7) Antibodies

cullin 7 , CUL-7 , cullin-7 , cullin-7-like

481807 Canis lupus familiaris
504558 Bos taurus
472011 Pan troglodytes
699545 Macaca mulatta
100067262 Equus caballus
100141398 Sus scrofa
100172168 Pongo abelii
100476447 Ailuropoda melanoleuca
9820 Homo sapiens
66515 Mus musculus
363191 Rattus norvegicus
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