Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 Proteins (CYP1A2)

CYP1A2 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP1A2 Antibodies (189) and CYP1A2 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP1A2 1544 P05177
CYP1A2 13077 P00186
CYP1A2 24297 P04799
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Top CYP1A2 Proteins at

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Yeast (Pichia pastoris) Human Un-conjugated   10 mg Log in to see 2 to 3 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Rat T7 tag,His tag   100 μg Log in to see 15 to 18 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days

CYP1A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

Top referenced CYP1A2 Proteins

  1. Human CYP1A2 Protein expressed in Wheat germ - ABIN1350938 : Kawakami, Ohtsuki, Kamiie, Suzuki, Abe, Terasaki: Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection. in Journal of pharmaceutical sciences 2010 (PubMed)

More Proteins for Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2) Interaction Partners

Rabbit Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2) interaction partners

  1. CYP1A1 (show CYP1A1 Proteins) and CYP1A2 localization into different lipid microdomains is governed by their N-terminal and internal protein regions

  2. Removal of cholesterol (an important constituent of ordered domains) led to the relocation of CYP1A2, CYP2B4 and CPR (show POR Proteins) to the disordered regions.

  3. Oxidation kinetics of toluene in CYP1A2-CYP2B4 mixtures with and without cytochrome p450 reductase (CPR (show POR Proteins)) are consistent with a model in which CYP1A2 has a higher affinity for CPR (show POR Proteins) binding.

Human Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2) interaction partners

  1. findings suggest that CYP1A2 alleles or haplotypes were not predictive of metabolic phenotypes in the Nigerian population; carriers of CYP2A6 (show CYP2A6 Proteins)*9/*17 genotype are likely to be poor metabolisers of CYP2A6 (show CYP2A6 Proteins) substrates and may experience adverse reactions or poor efficacy while using drugs metabolised mainly by CYP2A6 (show CYP2A6 Proteins)

  2. frequency of slow activity CYP1A2 enzyme alleles is very low among Emiratis which correlates with the presence of low frequencies of derived alleles in CYP1A2 gene

  3. Study provided additional evidence that CYP1A2 is an important susceptibility gene for essential hypertension.

  4. Studied diosmetin effect on signal pathway and apoptosis in HepG2 cells. Dios-induced cell apoptosis could be reversed by p53 (show TP53 Proteins) blockade and the effects of Dios on cellular P53 (show TP53 Proteins) and CYP1A1/CYP1A2 (show CYP1A1 Proteins) proteins levels were examined. Found P53 (show TP53 Proteins), CYP1A1 (show CYP1A1 Proteins), and CYP1A2 proteins were up-regulated by diosmetin; p53 (show TP53 Proteins) downregulation by pifithrin caused inhibition of apoptosis.

  5. the difference in clozapine levels between smokers and nonsmokers appeared to be significant in the individuals carrying the homozygous -163A allele (P=0.02). It was also found that nonsmokers carrying the -163A allele tended to have higher plasma levels of clozapine. Cigarette smoking has a significant impact on the plasma level of clozapine in schizophrenic patients carrying the homozygous -163A allele in the CYP1A2 gen

  6. genetic association studies in population in Spain: Data suggest that an SNP in CYP1A2 (-163C>A; rs762551) is not associated with performance enhancement/visual attention effects in response to moderate caffeine consumption as dietary supplement (capsules) during exercise; C-allele carriers reported increased nervousness after caffeine ingestion.

  7. We conducted a genome-wide association study (GWAS) of plasma caffeine, paraxanthine, theophylline, theobromine and paraxanthine/caffeine ratio. A single SNP at 6p23 (near CD83 (show CD83 Proteins)) and several SNPs at 7p21 (near AHR (show AHR Proteins)), 15q24 (near CYP1A2) and 19q13.2 (near CYP2A6 (show CYP2A6 Proteins)) met GW-significance (P < 5 x 10-8) and were associated with one or more metabolites

  8. We observed a strong dose-dependent increase in hair PhIP (show PHIP Proteins) levels. This increase was highly correlated with dose received (rho = 0.68, P < 0.0001).CYP1A2 activity and normalizing for hair melanin did not modify the response to the intervention.

  9. findings indicated that the -3860 G > A polymorphism in CYP1A2 might not be a risk factor for lung cancer [meta-analysis]

  10. CYP1A2-163C/A polymorphism is associated with increased susceptibility to bladder cancer in the Chinese population.

Mouse (Murine) Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2) interaction partners

  1. our results suggest a more important contribution of CYP1A2 (show CYP1A1 Proteins) to the in vivo plasma clearance and thus detoxification of 4-Aminobiphenyl

  2. hepatic CYP1A2 (show CYP1A1 Proteins) plays a critical role in the attenuation of hyperoxic lung injury by decreasing lipid peroxidation and oxidative stress in vivo.

  3. Aryl hydrocarbon receptor (show AHR Proteins) mediated induction of hepatic CYP1A1 (show CYP1A1 Proteins)/1A2 is dependent on the presence of ctnnb1 (show CTNNB1 Proteins).

  4. Results indicate Cyp1a2 (show CYP1A1 Proteins) genotype is important in susceptibility to PCB (show PC Proteins)-induced deficits in learning and memory.

  5. Miroestrol and deoxymiroestrol significantly up-regulated CYP2B9 while suppressing CYP1A2 (show CYP1A1 Proteins) at both transcriptional and enzymatic levels.

  6. A report of uroporphyria development in Cyp1a2 (show CYP1A1 Proteins)-/- mice additionally null for both alleles of the hemochromatosis (Hfe (show HFE Proteins)) gene and heterozygous for deletion of the uroporphyrinogen decarboxylase (Urod (show UROD Proteins)) gene (genotype: Cyp1a2 (show CYP1A1 Proteins)-/-;Hfe (show HFE Proteins)-/-;Urod (show UROD Proteins)+/-).

  7. High levels of maternal hepatic CYP1A2 (show CYP1A1 Proteins) protect against deficits in learning and memory in offspring exposed to a mixture of coplanar and noncoplanar PCBs; high-affinity AHR (show AHR Proteins) is the next most important factor in protection of offspring.

  8. In rodents, aristolochic acid demethylation, mediated by CYP1A2 (show CYP1A1 Proteins), is a primary pathway of aristolochic acid detoxication.

  9. The expression of Cyp1a1 (show CYP1A1 Proteins), Cyp1a2 (show CYP1A1 Proteins), and OGG1genes was significantly up-regulated in mice given diets containing 375 ppm dicyclanil or more.

  10. the TRE (show TREH Proteins) element in E1 is essential for constitutive expression of the mouse Cypla2 gene

Pig (Porcine) Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2) interaction partners

  1. In the present study, CYP1A2 expression in liver increased in groups exposed to single exposures of 5 mgkg-bw- 1 (p = 0.044) and 20 mgkg-bw- 1 (p = 0.033) relative to controls

  2. This study demonstrated for the first time that the serum testosterone level is one of the physiological factors which regulate constitutive expression of hepatic CYP1A1 (show CYP1A1 Proteins) and CYP1A2 in pigs.

  3. The findings demonstrate a gender-related difference in the constitutive expression of hepatic CYP1A2 in Meishan pigs and further indicate that testosterone down-regulates the constitutive gene expression of the enzyme.

  4. Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2

  5. Effect of beta-napthoflavone on AHR (show AHR Proteins)-related gene, CYP1A2, in the pig is reported.

CYP1A2 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown\; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

Gene names and symbols associated with CYP1A2

  • cytochrome P450 1A2 (VDBG_06455)
  • cytochrome P450 1A2 (CYP1A2)
  • cytochrome P450 1A2-like (LOC101825565)
  • cytochrome P450 LM4 (LOC100328937)
  • cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2)
  • cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2)
  • CP12 protein
  • CP450 protein
  • CYP-IA2 protein
  • Cyp1a1 protein
  • CYP1A2 protein
  • CYPD45 protein
  • CYPIA-2 protein
  • CYPIA2 protein
  • P-450d protein
  • P3-450 protein
  • P450(PA) protein
  • P450-3 protein
  • P450-PM4 protein
  • RATCYPD45 protein

Protein level used designations for CYP1A2

cytochrome P450 1A2 , CYPIA2 , Cytochrome P450-MC4 , Hepatic cytochrome P-450MC1 , cytochrome P-450 form 4 , cytochrome P-450IA2 , pulmonary cytochrome P-450MC1 , P450 LM4 , P450 isozyme 4 , cytochrome P450 isozyme 4 , cytochrome P450-PM4 , P450 form 4 , aryl hydrocarbon hydroxylase , cytochrome P(3)450 , cytochrome P450 4 , cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2 , cytochrome P450-P3 , dioxin-inducible P3-450 , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase , aromatic compound inducible , cytochrome P450 family 1 subfamily a polypeptide 1 , cytochrome P450, 1a2, aromatic compound inducible , cytochrome P450-P2 , Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d) , P-448 , P450-D , cytochrome P-448 , cytochrome P-450d , cytochrome P450, 1a2 , cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d) , cytochrome P450-D

9536166 Verticillium alfalfae VaMs.102
554345 Felis catus
101825565 Mesocricetus auratus
100328937 Oryctolagus cuniculus
1544 Homo sapiens
13077 Mus musculus
24297 Rattus norvegicus
414856 Gallus gallus
494010 Canis lupus familiaris
100135513 Cavia porcellus
100152910 Sus scrofa
100172368 Pongo abelii
100392712 Callithrix jacchus
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