Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 Proteins (CYP2A6)

CYP2A6, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP2A6 Antibodies (108) and CYP2A6 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP2A6 1548 P11509
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Top CYP2A6 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

CYP2A6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6) Interaction Partners

Pig (Porcine) Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6) interaction partners

  1. Polymorphisms within the CYP2A6 gene are not a significant cause of high skatole levels.

Human Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6) interaction partners

  1. findings suggest that CYP1A2 (show CYP1A2 Proteins) alleles or haplotypes were not predictive of metabolic phenotypes in the Nigerian population; carriers of CYP2A6*9/*17 genotype are likely to be poor metabolisers of CYP2A6 substrates and may experience adverse reactions or poor efficacy while using drugs metabolised mainly by CYP2A6

  2. Genetic polymorphisms in CYP2B6 (show CYP2B6 Proteins) and CYP2A6 explained a significant proportion of variability in EFV plasma concentration in HIV-infected children in a multi-ethnic outpatient clinic.

  3. In a Mexican Mestizo population, rs1137115(A) and rs4105144(T) in CYP2A6 are associated with cigarette consumption

  4. CYP2B6 (show CYP2B6 Proteins)/CYP2A6 genotypes were associated with increased reported suicidality among AIDS patients who had been randomly assigned to receive efavirenz-containing regimens in clinical trials. Strength of association varied by race/ethnicity.

  5. The CYP2A6 gene product plays a major role in the nicotine metabolism pathway, which influences nicotine intake.

  6. CYP2A6 activity provides information on lung cancer risk that is not captured by smoking history.

  7. CYP2A6*4 genetic polymorphisms may not strongly affect smoking behavior but may possibly have an effect on nicotine dependence

  8. CYP2A6 genetic variation alters striatal-cingulate circuits, network hubs, and executive processing in smokers. Because the CYP2A6 effect was seen only in smokers, these data suggest that the rate of nicotine metabolism-and thus the concentration of nicotine presented to the brain over the course of nicotine addiction-shapes brain circuits that, among other functions, compute reward and impulsivity processes.

  9. a greater CYP2A6 activity causes smokers to smoke more extensively and be exposed to higher levels of carcinogens, resulting in an increased risk for lung cancer.

  10. Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype

CYP2A6 Protein Profile

Protein Summary

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3\; however, it has been renamed CYP2A6.

Gene names and symbols associated with CYP2A6

  • cytochrome P450 2A19 (CYP2A19)
  • cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6)
  • CPA6 protein
  • CYP2A protein
  • CYP2A3 protein
  • CYP2A6 protein
  • CYPIIA6 protein
  • P450C2A protein
  • P450PB protein

Protein level used designations for CYP2A6

coumarin 7-hydroxylase , cytochrome p450 2A6 , 1,4-cineole 2-exo-monooxygenase , cytochrome P450 2A6 , cytochrome P450 IIA3 , cytochrome P450(I) , cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6 , flavoprotein-linked monooxygenase , xenobiotic monooxygenase

GENE ID SPECIES
403149 Sus scrofa
1548 Homo sapiens
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