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Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 Proteins (CYP2C9)

CYP2C9 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP2C9 Antibodies (61) and CYP2C9 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP2C9 1559 P11712
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Top CYP2C9 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
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HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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HOST_Yeast (Pichia pastoris) Human Un-conjugated   10 mg Log in to see 2 to 3 Days
$157.50
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CYP2C9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,

More Proteins for Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 (CYP2C9) Interaction Partners

Human Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 (CYP2C9) interaction partners

  1. Three SNPs (CYP2C9 *2, *3 and VKORC1 (show VKORC1 Proteins) c.-1639G > A) were genotyped by electrochemical detection using a sandwich-type format that included a 3' short thiol capture probe and a 5' ferrocene-labeled signal probe.

  2. This study was aimed to describe the distribution of CYP2C9 and CYP2C19 (show CYP2C19 Proteins) alleles and haplotypes in four Mestizo populations from Western Mexico. Frequencies ranged from 2.2-3.0% and 4.8-8.9% for CYP2C9*3 and CYP2C9*2 alleles, respectively, and 5.4-12.0% for CYP2C19 (show CYP2C19 Proteins)*2, whereas the CYP2C19 (show CYP2C19 Proteins)*3 allele was not found.

  3. CYP2C9 IVS8-109 T carriers showed significantly higher dose-corrected phenoytoin blood concentrations and this allele was found in a higher frequency in epileptic patients with supratherapeutic phenytoin levels.

  4. Med25 (show MED9 Proteins), a variable member of the Mediator complex, is a coactivator of ligand-activated ERalpha (show ESR1 Proteins) that interacts with ERalpha (show ESR1 Proteins) through its C-terminal LXXLL motif after BPA (show DST Proteins) exposure, and is functionally involved in BPA (show DST Proteins)-induced transcriptional regulation of CYP2C9 expression and enzyme activity.

  5. We conclude that CYP2C9/2C19 genotype is not relevant for variability in valproic acid exposure.

  6. Our results show that anticoagulated patients have a high risk of adverse events if they are carriers of 1 or more genetic polymorphisms in the VKORC1 (show VKORC1 Proteins) (rs9923231) and CYP2C9 (rs1799853 and rs1057910) genes.

  7. Review/Meta-analysis: CYP2C9 gene polymorphism was significantly associated with decreased warfarin maintenance dose requirements in pediatric patients.

  8. The intrinsic clearance (Vmax/Km) values of all variants, with the exception of CYP2C9*2, CYP2C9*11, CYP2C9*23, CYP2C9*29, CYP2C9*34, CYP2C9*38, CYP2C9*44, CYP2C9*46 and CYP2C9*48, were significantly different from CYP2C9*1. CYP2C9*27, *40, *41, *47, *49, *51, *53, *54, *56 and N418T variant exhibited markedly larger values than CYP2C9*1.

  9. Report roles for CYP3A4 (show CYP3A4 Proteins) and CYP2C9 in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.

  10. CYP2C9*2 and *3 variants were not detected and may not be the most important genetic factor for warfarin maintenance dose among Ghanaians.

CYP2C9 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Gene names and symbols associated with CYP2C9

  • cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9)
  • CPC9 protein
  • CYP2C protein
  • CYP2C10 protein
  • CYPIIC9 protein
  • P450IIC9 protein

Protein level used designations for CYP2C9

cytochrome P-450 S-mephenytoin 4-hydroxylase , cytochrome P-450MP , cytochrome P450 2C9 , cytochrome P450 PB-1 , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase

GENE ID SPECIES
1559 Homo sapiens
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