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Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 Proteins (CYP27A1)

CYP27A1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP27A1 Antibodies (52) and CYP27A1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP27A1 1593 Q02318
CYP27A1 104086 Q9DBG1
Rat CYP27A1 CYP27A1 301517 P17178
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Top CYP27A1 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

CYP27A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) Interaction Partners

Human Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) interaction partners

  1. A significant decrease in the expression level of CYP27A1 in female patients could indicate their greater vulnerability to multiple sclerosis than the male patients.

  2. CYP27A1 belongs to the mitochondrial CYPs and plays a crucial role in the cholesterol homeostasis.

  3. Analysis of ~60,000 human exomes points to underdiagnosis of cerebrotendinous xanthomatosis due to CYP27A1 mutations.

  4. marinobufagenin is derived from bile acids and its biosynthesis is initiated by CYP27A1 enzyme

  5. The 25-hydroxylases CYP2R1 (show CYP2R1 Proteins) and CYP27A1 catalyze vitamin D to its circulating form 25-hydroxyvitamin D.

  6. In a patient with cerebrotendinous xanthomatosis, analysis of the CYP27A1 gene identified compound heterozygosity for p.A335V, a novel mutation.

  7. study describes two unrelated Sardinian families sharing the same CYP27A1 mutation, p.Arg479Cys; phenotype of the patients is characteristic of cerebrotendinous xanthomatosis

  8. The increased cutaneous CYP27B1 (show CYP27B1 Proteins) levels in the CKD patients suggest that the loss of renal activity of this enzyme is at least partially compensated for by the skin.

  9. Cyp27A1 mutations were identified in early onset CAD pedigree.

  10. Studied whether abnormal endometrial expression of CYP27A1 and/or CYP2R1 (show CYP2R1 Proteins) may impair VDR (show CYP27B1 Proteins)-antiproliferative properties in endometrial carcinoma.

Mouse (Murine) Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) interaction partners

  1. The cholesterol diet reduced the levels of the "memory protein" Arc (Activity Regulated Cytoskeleton associated protein (show Arc Proteins)) in the hippocampus of the wildtype mice but not in the hippocampus of the Cyp27-/- mice.

  2. overexpression of Cyp27a1 in KCs reduces hepatic inflammation independently of 27HC levels in plasma and liver, further pointing towards KCs as specific target for improving the therapy of NASH (show SAMSN1 Proteins).

  3. Data indicate that inhibition of CYP27A1 activity or knockdown and deletion of the Cyp27a1 gene induced adipocyte differentiation.

  4. The expression of CYP27A1 modulates the concentrations of active glucocorticoids in both humans and mice and in vitro.

  5. Loss of CYP27A1 led to dysregulation of retinal cholesterol homeostasis, including unexpected upregulation of retinal cholesterol biosynthesis. Cyp27a1-/- mice developed retinal lesions with cholesterol deposition beneath the retinal pigment epithelium.

  6. CYP27(-/-) mice exhibited enhanced CCl(4 (show CCL4 Proteins))-induce liver injury, and defective liver regeneration and prolonged steatosis after 70% partial hepatectomy.

  7. Results are consistent with a concentration-dependent flux of 7alpha-hydroxy-4-cholesten-3-one across the blood-brain barrier in cyp27a1(-/-) mice and subsequent formation of cholestanol.

  8. In CYP27A1 ko mice, urinary progesterone concentrations were decreased, 20alpha-DH-progesterone increased, and the progesterone-to-20alpha-DH-progesterone ratio decreased threefold

  9. Hepatic neutral cytosolic cholesteryl ester hydrolase decreased mRNAs for cholesterol 7alpha-hydroxylase (show CYP7A1 Proteins), sterol 27-hydroxylase, and HMG-CoA reductase (show HMGCR Proteins) on day 7 after transfection, coinciding with peak hepatic free cholesterol concentrations

Cow (Bovine) Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) interaction partners

  1. isoLG adduction impairs enzyme activity, and support our hypothesis that isoLG modification in the retina is detrimental to CYP27A1 enzyme activity, potentially disrupting cholesterol homeostasis.

  2. Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 (show POR Proteins) CYP27A1 and CYP11A1 (show CYP11A1 Proteins).

  3. Sterol 27-hydroxylase cytochrome P450 27A1 (CYP27A1) is involved in elimination of 7-ketocholesterol from the retinal pigment epithelium.

CYP27A1 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.

Gene names and symbols associated with CYP27A1

  • cytochrome P450, family 27, subfamily A, polypeptide 1 (CYP27A1)
  • cytochrome P450, family 27, subfamily a, polypeptide 1 (Cyp27a1)
  • sterol 26-hydroxylase, mitochondrial (CYP27A1)
  • vitamin D3 25-Hydroxylase (CYP2D25)
  • 1300013A03Rik protein
  • CP27 protein
  • CTX protein
  • Cyp27 protein
  • CYPIID25 protein
  • P450C27 protein

Protein level used designations for CYP27A1

5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase , 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase , 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase , cholestanetriol 26-monooxygenase , cytochrome P-450C27/25 , cytochrome P450 27 , cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1 , sterol 26-hydroxylase, mitochondrial , sterol 27-hydroxylase , vitamin D(3) 25-hydroxylase , cholesterol 27 hydroxylase , cytochrome P450, 27 , cytochrome P450, 27a1 , cytochrome P-450c27/25 , cytochrome P-450 , cytochrome P450 2D25

1593 Homo sapiens
104086 Mus musculus
610489 Canis lupus familiaris
100126282 Sus scrofa
511960 Bos taurus
301517 Rattus norvegicus
100348736 Oryctolagus cuniculus
397687 Sus scrofa
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