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DIRAS Family, GTP-Binding RAS-Like 3 Proteins (DIRAS3)

DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. Additionally we are shipping DIRAS3 Antibodies (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DIRAS3 9077 O95661
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Top DIRAS3 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

DIRAS3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

Top referenced DIRAS3 Proteins

  1. Human DIRAS3 Protein expressed in Human - ABIN2719498 : Zhang, Lu, Mao, Ahmed, Yang, Zhou, Jennings, Rodriguez-Aguayo, Lopez-Berestein, Miranda, Qiao, Baladandayuthapani, Li, Sood, Liu, Le, Bast: CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. in PLoS ONE 2015 (PubMed)

More Proteins for DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) Interaction Partners

Pig (Porcine) DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) interaction partners

  1. polymorphism-based approach was used to detect the imprinting status of NNAT (show NNAT Proteins) and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1) hybrids

Human DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) interaction partners

  1. Transcriptional, but not post-transcriptional, silencing of GNG12-AS1 (show PTGDR Proteins) causes concomitant upregulation of DIRAS3, indicating a function in transcriptional interference.

  2. ARHI mRNA and protein expression is markedly decreased in osteosarcoma MG-63 cells lines. Overexpression of ARHI inhibits cell viability and proliferation.

  3. ARHI-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.

  4. EZH2 (show EZH2 Proteins)-''induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in epithelial ovarian cancer

  5. ARHI competes with RanGTPase and interacts with importin beta (show KPNB1 Proteins) via basic-acidic patch interaction, which leads to inhibition of STAT3 (show STAT3 Proteins) translocation.

  6. Letter: ARHI suppresses pancreatic cancer by regulating ERK 1 (show MAPK3 Proteins)/2 signaling.

  7. JMJD2A (show KDM4A Proteins)-dependent silencing of Sp1 (show PSG1 Proteins) in advanced breast cancer promotes metastasis by downregulation of DIRAS3.

  8. suggest that DIRAS3 not only regulates the autophagosome initiation complex, but induces autophagy in dormant, nutrient-deprived ovarian cancer cells that remain after conventional chemotherapy, facilitating their survival

  9. ARHI is required for autophagy-meditated cancer cell arrest and ARHI inhibits signaling through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and Ras/MAP by enhancing internalization and degradation of the epidermal growth factor receptor (show EGFR Proteins).

  10. The silence of ARHI expression in vitro seems to accelerate the malignant transformation of healthy ovarian cells by restraining apoptosis and autophagy.

DIRAS3 Protein Profile

Protein Summary

This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers.

Gene names and symbols associated with DIRAS3

  • DIRAS family, GTP-binding RAS-like 3 (DIRAS3)
  • DIRAS family, GTP-binding RAS-like 3 (diras3)
  • ARHI protein
  • DIRAS3 protein
  • NOEY2 protein

Protein level used designations for DIRAS3

DIRAS family, GTP-binding RAS-like 3 , GTP-binding protein Di-Ras3 , GTP-binding RAS-like protein 3 , distinct subgroup of the Ras family member 3 , ras homolog gene family, member I , rho-related GTP-binding protein RhoI

456930 Pan troglodytes
504559 Bos taurus
701273 Macaca mulatta
733668 Sus scrofa
100135197 Xenopus (Silurana) tropicalis
100147791 Ovis aries
9077 Homo sapiens
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