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DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. Additionally we are shipping DIRAS3 Antibodies (41) and many more products for this protein.
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polymorphism-based approach was used to detect the imprinting status of NNAT (show NNAT Proteins) and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1) hybrids
Transcriptional, but not post-transcriptional, silencing of GNG12-AS1 (show PTGDR Proteins) causes concomitant upregulation of DIRAS3, indicating a function in transcriptional interference.
ARHI mRNA and protein expression is markedly decreased in osteosarcoma MG-63 cells lines. Overexpression of ARHI inhibits cell viability and proliferation.
ARHI-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.
EZH2 (show EZH2 Proteins)-''induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in epithelial ovarian cancer
ARHI competes with RanGTPase and interacts with importin beta (show KPNB1 Proteins) via basic-acidic patch interaction, which leads to inhibition of STAT3 (show STAT3 Proteins) translocation.
Letter: ARHI suppresses pancreatic cancer by regulating ERK 1 (show MAPK3 Proteins)/2 signaling.
JMJD2A (show KDM4A Proteins)-dependent silencing of Sp1 (show PSG1 Proteins) in advanced breast cancer promotes metastasis by downregulation of DIRAS3.
suggest that DIRAS3 not only regulates the autophagosome initiation complex, but induces autophagy in dormant, nutrient-deprived ovarian cancer cells that remain after conventional chemotherapy, facilitating their survival
ARHI is required for autophagy-meditated cancer cell arrest and ARHI inhibits signaling through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and Ras/MAP by enhancing internalization and degradation of the epidermal growth factor receptor (show EGFR Proteins).
The silence of ARHI expression in vitro seems to accelerate the malignant transformation of healthy ovarian cells by restraining apoptosis and autophagy.
This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers.
DIRAS family, GTP-binding RAS-like 3
, GTP-binding protein Di-Ras3
, GTP-binding RAS-like protein 3
, distinct subgroup of the Ras family member 3
, ras homolog gene family, member I
, rho-related GTP-binding protein RhoI