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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Antibodies (254) and DNMT3A Kits (3) and many more products for this protein.
Showing 6 out of 7 products:
Human DNMT3A Protein expressed in Human - ABIN2719617
Cree, Fredericks, Miller, Pearce, Filichev, Fee, Kennedy: DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. in FEBS letters 2016
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Proteins), Dnmt3a, Hdac1 (show HDAC1 Proteins), Kdm3a (show KDM3A Proteins) and Uhrf1 (show UHRF1 Proteins) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
Expression of miR (show MLXIP Proteins)-26a and miR (show MLXIP Proteins)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7 (show ADAMTS7 Proteins), ATP1B1 (show ATP1B1 Proteins), COL4A2 (show COL4a2 Proteins), CPEB3 (show CPEB3 Proteins), CDK6 (show CDK6 Proteins), DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.
DNMT3A polymorphism plays a major role in the pathogenesis of late-onset Alzheimer's disease and can be used as a stratification marker to predict an individual's susceptibility.
We suggest that 2p23 microdeletion including DNMT3A may cause similar symptoms in patients with DNMT3A mutations and should be considered in patients with overgrowth.
Identification of DNMT3A and IDH1/IDH2 mutations is instrumental for early detection of acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation.
We found that pre-miR (show MLXIP Proteins)-29c or miR (show MLXIP Proteins)-29c mimics significantly increases the expression level of miR (show MLXIP Proteins)-34c and miR (show MLXIP Proteins)-449a. We further found DNA methyltransferase 3a and 3b are the target gene of miR (show MLXIP Proteins)-29c
Our findings first demonstrated that DNMT3a rs1550117 polymorphism may be a potential biomarker in predicting overall survival of gastric cancer patients
DNMT3A is frequently mutated in T-ALL and is associated with distinct clinicopathologic entities and a poor prognosis.
findings suggest that mutations in the DNMT3A gene can only be used as a biomarker for those AML (show RUNX1 Proteins) patients in whom DNMT3A mutation is lost after therapy
The HBVX gene upregulated the mRNA and protein expression levels of DNMT3A/3B, downregulated the expression of SOCS1 (show SOCS1 Proteins) and increased SOCS1 (show SOCS1 Proteins) gene promoter CpG island methylation.
DNMT3a is a direct target of miR143.
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Proteins) content are rather a function of time, and not a genetic component.
The effect of p53 (show TP53 Proteins) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Proteins) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (show DNMT3B Proteins) were associated with several beef quality traits.
Cigarette smoke induces proteosomal-mediated degradation of DNMT3a in embryonic orofacial cells.
The stress-induced Brg1 (show SMARCA4 Proteins)-G9a (show EHMT2 Proteins)/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Proteins) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
both the PML (show PML Proteins)-RARA (show RARA Proteins)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML Proteins) (APL (show FASL Proteins)) required DNMT3A
Overexpression or knockdown of medial prefrontal cortex Dnmt3a levels decreases or increases anxiety-like behavior, respectively.
DKO cardiomyocytes showed virtual absence of targeted Dnmt3a and Dnmt3b (show DNMT3B Proteins) mRNA transcripts.
An unexpected oncogenic role for Dnmt3a in MTCL through methylation-independent repression of Dnmt3b (show DNMT3B Proteins).
knock-outs display loss of DNA methylation (show HELLS Proteins) at transcriptional start site of long non-coding RNAs enriched in hematopoietic stem cells
These results indicated a role for the miR29b-Dnmt3a/3b-DNA methylation (show HELLS Proteins) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development
Our results suggest that DNMT3A mutations and oncogenic RAS cooperate to regulate hematopoietic stem and progenitor cells and promote myeloid malignancies.
data suggest that Dnmt3a and Dnmt3b (show DNMT3B Proteins) are critical to regulate the onset of Igkappa light chain rearrangement during early B-cell development
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA