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DNA (Cytosine-5-)-Methyltransferase 3 alpha Proteins (DNMT3A)

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Antibodies (208) and DNMT3A Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNMT3A 1788 Q9Y6K1
Rat DNMT3A DNMT3A 444984 Q1LZ53
DNMT3A 13435 O88508
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Top DNMT3A Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

DNMT3A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)

More Proteins for DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaction Partners

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Proteins), Dnmt3a, Hdac1 (show HDAC1 Proteins), Kdm3a (show KDM3A Proteins) and Uhrf1 (show UHRF1 Proteins) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Our findings demonstrated a significant association between DNMT3A rs1550117 A>G polymorphism and increased risk of cancer in three genetic models. Meta-analysis.

  2. DNMT3A mutations provides the first proof-of-principle investigation on the identification of preleukemic stem cells in Acute myeloid leukemia (show BCL11A Proteins) patients.

  3. DNMT3A R882 mutation is associated with elevated expression of MAFB (show MAFB Proteins) and M4/M5 immunophenotype of acute myeloid leukemia (show BCL11A Proteins) blasts.

  4. DNMT3A mutants can block the differentiation of HSCs and leukaemic cells via PRC1 (show PRC1 Proteins).

  5. DNMT3A mutation was a poor prognostic factor in MLL (show MLL Proteins)-partial tandem duplication Acute myeloid leukemia (show BCL11A Proteins).

  6. To correlate DNMTs expression with DNA methylation (show HELLS Proteins), DNMT1 (show DNMT1 Proteins), DNMT3A and DNMT3B (show DNMT3B Proteins) mRNA levels in 5 colorectal cancer cell lines; results suggest that cellular DNMT (show DNMT1 Proteins) expression is positively correlated with global DNA methylation (show HELLS Proteins) level but not with regional DNA hypermethylation at each locus.

  7. DNA methyltransferase 3A promotes cell proliferation by silencing CDK (show CDK4 Proteins) inhibitor p18INK4C (show CDKN2C Proteins) in gastric carcinogenesis

  8. DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.

  9. Among 864 Dutch persons between 80 and 105.8 years of age, DNA sequence analysis of DNMT3A confirmed a high incidence of somatic mutations but no effect on 10-year survival.

  10. Data suggest that microRNA miR (show MLXIP Proteins)-101 may inhibit MDA-MB-231 breast cancer cell proliferation and migration by repressing DNA methyltransferase 3a (DNMT3a) expression and up-regulating E-cadherin (show CDH1 Proteins) expression.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Proteins) content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. The effect of p53 (show TP53 Proteins) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Proteins) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (show DNMT3B Proteins) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. The stress-induced Brg1 (show SMARCA4 Proteins)-G9a (show EHMT2 Proteins)/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Proteins) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.

  2. both the PML (show PML Proteins)-RARA (show RARA Proteins)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML Proteins) (APL (show FASL Proteins)) required DNMT3A

  3. Overexpression or knockdown of medial prefrontal cortex Dnmt3a levels decreases or increases anxiety-like behavior, respectively.

  4. DKO cardiomyocytes showed virtual absence of targeted Dnmt3a and Dnmt3b (show DNMT3B Proteins) mRNA transcripts.

  5. An unexpected oncogenic role for Dnmt3a in MTCL through methylation-independent repression of Dnmt3b (show DNMT3B Proteins).

  6. knock-outs display loss of DNA methylation (show HELLS Proteins) at transcriptional start site of long non-coding RNAs enriched in hematopoietic stem cells

  7. These results indicated a role for the miR29b-Dnmt3a/3b-DNA methylation (show HELLS Proteins) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development

  8. Our results suggest that DNMT3A mutations and oncogenic RAS cooperate to regulate hematopoietic stem and progenitor cells and promote myeloid malignancies.

  9. data suggest that Dnmt3a and Dnmt3b (show DNMT3B Proteins) are critical to regulate the onset of Igkappa light chain rearrangement during early B-cell development

  10. These correlational data suggest that DNA methylation (show HELLS Proteins) via Dnmt3a in the hippocampus co-regulates adaptivity of the behavioral response to chronic social defeat stress

DNMT3A Protein Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with DNMT3A

  • DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A)
  • DNA methyltransferase 3A (dnmt3a)
  • DNA (cytosine-5-)-methyltransferase 3 alpha (Dnmt3a)
  • DNA methyltransferase 3A (Dnmt3a)
  • DNMT3A protein
  • DNMT3A2 protein
  • M.HsaIIIA protein
  • MmuIIIA protein

Protein level used designations for DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
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