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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Antibodies (262) and DNMT3A Kits (3) and many more products for this protein.
Showing 6 out of 7 products:
Human DNMT3A Protein expressed in Human - ABIN2719617
Cree, Fredericks, Miller, Pearce, Filichev, Fee, Kennedy: DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. in FEBS letters 2016
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Proteins), Dnmt3a, Hdac1 (show HDAC1 Proteins), Kdm3a (show KDM3A Proteins) and Uhrf1 (show UHRF1 Proteins) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
Study provides evidence that Arg882-mutated DNMT3A contributes to acute myeloid leukemia (show BCL11A Proteins) pathogenesis through epigenetic activation of leukemia-related genes.
Downregulation of DNMT3a regulated miR (show MLXIP Proteins)-182 via caspase-3 (show CASP3 Proteins) and -9-mediated apoptosis and DNA damage response in ovarian cancer.
Approximately 22% of AML (show RUNX1 Proteins) and 36% of cytogenetically normal AML (show RUNX1 Proteins) cases carry DNMT3A mutations and around 60% of these mutations affect the R882 codon. These mutations have been associated with poor prognosis and adverse survival outcomes for AML (show RUNX1 Proteins) patients.
The DNMT3A -448A > G polymorphism may be a novel functional SNP and contribute to its genetic susceptibility to spontaneous abortion in Chinese women, and ART may not affect the distribution of -448A > G in pregnancy loss and normal pregnancy. The observed TT genotype of DMNT3B suggests that this is the predominant genotype of this population
Significant upregulation of DNMT1 (show DNMT1 Proteins), DNMT3A, and DNMT3B (show DNMT3B Proteins) expression was found in para-carcinoma tissues, compared with the histopathologically unchanged tissues furthermore, distinguishable expression profiling was observed of target miRNAs in tissues with different distance
A potential role of rs2424913 (DNMT3B (show DNMT3B Proteins)) and rs2228611 (DNMT1 (show DNMT1 Proteins)) in autoimmune thyroid diseases (AITD) susceptibility and identified novel gene-gene/gene-sex interactions in AITD. This may highlight sex and genes of DNMTs family as contributors to the pathogenesis of AITD.
these observations demonstrates a novel epigenetic feedback loop between miR (show MLXIP Proteins)-200c and DNMT3a in the carcinogenesis and progression of gastric cancer
miR (show MLXIP Proteins)-29b was negatively correlated with DNMT3A/3B expression at the cellular/histological levels.
mRNA and protein expression levels of DNMT3a were upregulated in genotype 1b and 3a HCV-infected hepatocellular carcinoma patients as compared to control. No differences were seen for genotypes 5 and 7.
These results suggested that miR200b has an important role in hepatocarcinogenesis and acts by downregulating DNMT3a expression.
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Proteins) content are rather a function of time, and not a genetic component.
The effect of p53 (show TP53 Proteins) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Proteins) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (show DNMT3B Proteins) were associated with several beef quality traits.
Dnmt3a is a haplo-insufficient (show TGFb Proteins) tumor suppressor in chronic lymphocytic leukemia and highlights the importance of deregulated molecular events in disease pathogenesis.
Cigarette smoke induces proteosomal-mediated degradation of DNMT3a in embryonic orofacial cells.
The stress-induced Brg1 (show SMARCA4 Proteins)-G9a (show EHMT2 Proteins)/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 Proteins) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
both the PML (show PML Proteins)-RARA (show RARA Proteins)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML Proteins) (APL (show FASL Proteins)) required DNMT3A
Overexpression or knockdown of medial prefrontal cortex Dnmt3a levels decreases or increases anxiety-like behavior, respectively.
DKO cardiomyocytes showed virtual absence of targeted Dnmt3a and Dnmt3b (show DNMT3B Proteins) mRNA transcripts.
An unexpected oncogenic role for Dnmt3a in MTCL through methylation-independent repression of Dnmt3b (show DNMT3B Proteins).
knock-outs display loss of DNA methylation (show HELLS Proteins) at transcriptional start site of long non-coding RNAs enriched in hematopoietic stem cells
These results indicated a role for the miR29b-Dnmt3a/3b-DNA methylation (show HELLS Proteins) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA