Dentin Sialophosphoprotein Proteins (DSPP)

DSPP encodes two principal proteins of the dentin extracellular matrix of the tooth. Additionally we are shipping Dentin Sialophosphoprotein Kits (26) and Dentin Sialophosphoprotein Antibodies (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DSPP 666279  
DSPP 25254  
DSPP 1834 Q9NZW4
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Top Dentin Sialophosphoprotein Proteins at

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

DSPP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus)

Human ,

More Proteins for Dentin Sialophosphoprotein (DSPP) Interaction Partners

Mouse (Murine) Dentin Sialophosphoprotein (DSPP) interaction partners

  1. no significant dentin malformation was observed in Mep1b (show MEP1B Proteins) (-/-) or Mep1a (show MEP1A Proteins) (-/-) deficient mice.

  2. overexpressing DPP inhibited skeletal development, suggesting that the balanced actions between the NH2- and COOH-terminal fragments of DSPP may be required for normal skeletal development.

  3. Klf10 is involved in tooth development and promotes odontoblastic differentiation via the up-regulation of Dmp1 (show DMP1 Proteins) and Dspp transcription.

  4. DMOG can enhance Dspp expression through VEGF (show VEGFA Proteins)-induced stabilization of Runx2 (show RUNX2 Proteins) protein.

  5. total dentin volume in DSPP KO animals significant changes in the ultrastructural organization exist

  6. the expression of DSPP precursor protein is required for normal odontoblast lineage differentiation

  7. DPP is essential for the formation of well-defined tooth structures with mineralized dentin matrix.

  8. continuous DSPP action is required for the growth and/or maintenance of the mandibular condylar cartilage

  9. Data indicate that that Wnt10a (show WNT10A Proteins) regulates Dspp expression in mesenchymal cells.

  10. Inactivation of DSPP leads to loss of alveolar bone and cementum in PDL of Dspp null mice. loss of DSPP results in periodontal diseases indicates that this molecule plays vital role in maintaining health of periodontium.

Human Dentin Sialophosphoprotein (DSPP) interaction partners

  1. This study expands the spectrum of DSPP variants, highlighting their associated phenotypic continuum.

  2. These data indicate that secretome derived from salivary gland cancer cells can influence the expression of two potential biomarkers of oral cancer-namely, bone sialoprotein (show CRISP1 Proteins) (BSP (show KLK6 Proteins)) and dentin sialoprotein (DSP)-in normal salivary gland cells.

  3. DSPP-MMP20 (show MMP20 Proteins) pair may play a role in the normal turnover of cell surface proteins and/or repair of pericellular matrix proteins of the basement membranes in the metabolically active duct epithelial system of the nephrons.

  4. BMP2 (show BMP2 Proteins) and RUNX2 (show RUNX2 Proteins) are expressed exclusively by osteoblasts whereas DSPP and LOXL2 (show LOXL2 Proteins) are expressed exclusively by odontoblasts. (Review)

  5. A novel pathogenic splicing-mutation c.52-1G>A of DSPP is associated with dentinogenesis imperfecta shields type II.

  6. expression of MMP-20 and co-expression and potential interaction with DSPP in human major salivary gland tissues

  7. mutations of the DSP-PP P4 to P4' cleavage site can block, impair or accelerate dentin sialoprotein phosphophoryn cleavage, and suggest that its Bone morphogenic protein 1 cleavage site is conserved in order to regulate its cleavage efficiency

  8. DMP1 (show DMP1 Proteins) and DSPP were more abundant in carious than in sound samples.

  9. Domain of dentine sialoprotein mediates proliferation and differentiation of human periodontal ligament stem cells.

  10. analysis of a mutation in DSPP causing dentinogenesis imperfecta and characterization of the mutational effect

Pig (Porcine) Dentin Sialophosphoprotein (DSPP) interaction partners

  1. The porcine dentin sialophosphoprotein has an N-terminal domain with at least six N-glycosylations and a C-terminal domain with two glycosaminoglycan attachments and at least two O-glycosylations.

  2. Astacins in the predentin matrix cleave Dspp.

  3. isolation of DSP from pig dentin and demonstration that it is a proteoglycan (show Vcan Proteins)

  4. isolation and characterization of a third domain of DSPP, designated dentin glycoprotein (DGP)

  5. correspondence between DSPP cleavage sites that occur in vivo and those generated in vitro demonstrates that MMP-2 (show MMP2 Proteins) and MMP-20 process DSPP into smaller subunits in the dentin matrix during odontogenesis

  6. DPP length variations are polymorphic and are not associated with dentin defects

  7. porcine DPP-derived arginyl-glycyl-aspartic acid peptide, but not its mutant arginyl-alanyl-aspartic acid peptide, significantly promoted cell migration

Dentin Sialophosphoprotein (DSPP) Protein Profile

Protein Summary

This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1\; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene.

Gene names and symbols associated with DSPP

  • dentin sialophosphoprotein (DSPP)
  • dentin sialophosphoprotein (Dspp)
  • dentin sialophosphoprotein (Patl_2314)
  • DFNA39 protein
  • DGI1 protein
  • Dmp2 protein
  • DMP3 protein
  • DPP protein
  • DSP protein
  • DTDP2 protein
  • RDSP2 protein

Protein level used designations for DSPP

dentin sialophosphoprotein , DMP-3 , dentin matrix protein 3 , Dentin sialoprotein , Dentine sialoprotein , dentin sailophosphoprotein , dentin phosphophoryn , dentin phosphoprotein , dentin phosphoryn , dentin sialoprotein

487849 Canis lupus familiaris
551799 Apis mellifera
100080849 Ornithorhynchus anatinus
4172468 Pseudoalteromonas atlantica T6c
666279 Mus musculus
25254 Rattus norvegicus
1834 Homo sapiens
101789124 Cavia porcellus
396664 Sus scrofa
100683557 Canis lupus familiaris
100337125 Bos taurus
776475 Gallus gallus
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