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Diaphanous Homolog 1 (Drosophila) (DIAPH1) ELISA Kits

DIAPH1 is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Additionally we are shipping DIAPH1 Antibodies (45) and DIAPH1 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat DIAPH1 DIAPH1 307483  
Anti-Mouse DIAPH1 DIAPH1 13367 O08808
DIAPH1 1729 O60610
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Top DIAPH1 ELISA Kits at antibodies-online.com

Showing 1 out of 2 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.051 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$736.84
Details

More ELISA Kits for DIAPH1 Interaction Partners

Mouse (Murine) Diaphanous Homolog 1 (Drosophila) (DIAPH1) interaction partners

  1. Diaphanous-related formin (show DIAPH3 ELISA Kits) signaling plays a role in heart and vascular development and the maintenance of SMC (show DYM ELISA Kits) phenotype.

  2. Liprin-alpha3 (show PPFIA3 ELISA Kits) uses an alpha-helical region to bind to mDia1, counteracting mouse Dia1 (show CYB5R3 ELISA Kits) activation by RhoA (show RHOA ELISA Kits).

  3. Depleting FMNL1 (show FMNL1 ELISA Kits), another Formin (show FMN1 ELISA Kits) family member, resulted in reduced mDia1 expression, while RhoA (show RHOA ELISA Kits) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (show FMNL1 ELISA Kits)-mDia1-Profilin1 (show PFN1 ELISA Kits) signaling pathway in mouse oocytes.

  4. Mechanistically, mDia1 deficiency led to a downregulation of membrane-associated genes and a specific upregulation of CD14 (show CD14 ELISA Kits) messenger RNA in granulocytes, but not in other lineages.

  5. Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization.

  6. mDia1 can efficiently put actin filaments under mechanical tension.

  7. The active form of mDia1 localized to the apical membrane in exocrine pancreas cells; introduction of an active form of mDia1 leads to a marked increase in actin bundle density along the secretory vesicle lumen perimeter.

  8. Dia1 (show CYB5R3 ELISA Kits) and Dia2 (show DIAPH3 ELISA Kits) are dynamic components of meiotic spindle and pole complex during meiotic maturation of oocytes.

  9. Actin-capping protein is a novel regulator of microtubule stability that functions by antagonizing mDia1 activity toward actin filaments.

  10. Full-length mouse mDia1 (mDia1-FL) forms tightly autoinhibited dimers that can only be partially activated by RhoA (show RHOA ELISA Kits).

Human Diaphanous Homolog 1 (Drosophila) (DIAPH1) interaction partners

  1. functional complementation experiments and optogenetics to show that mDia1 cooperates with the Arp2 (show ACTR2 ELISA Kits)/3 complex in initiating lamellipodia and ruffles.

  2. Capping protein and dia1 (show CYB5R3 ELISA Kits) functionally coregulate filament barbed-end assembly.

  3. mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return.

  4. Data indicate that diaphanous homolog 1 (Drosophila) protein (DIAPH1) stabilizes microtubules and reduces microtubule dynamics.

  5. Patients with a homozygous nonsense DIAPH1 alteration (p.Gln778*) have MCP (show CD46 ELISA Kits) as well as reduced height and weight.

  6. the RhoA (show RHOA ELISA Kits)-regulated formin (show FMN1 ELISA Kits) Dia1 (show CYB5R3 ELISA Kits) is involved in entosis downstream of LPAR2 (show LPAR2 ELISA Kits)

  7. DIAPH1 has a critical role in generating F-actin structures and assisting the microtubule stabilization underlying proplatelet formation and platelet production

  8. Dia1 (show CYB5R3 ELISA Kits), Dia2 (show DIAPH2 ELISA Kits), and Dia3 (show DIAPH2 ELISA Kits) are involved in ErbB2 (show ERBB2 ELISA Kits)-dependent capture of microtubules at the cell leading edge and ErbB2 (show ERBB2 ELISA Kits)-driven guided migration.

  9. Mechanistically, mDia1 deficiency led to a downregulation of membrane-associated genes and a specific upregulation of CD14 (show NDUFA2 ELISA Kits) messenger RNA in granulocytes, but not in other lineages.

  10. Depletion of DIAPH1 reduced metastasis 60-fold.

DIAPH1 Antigen Profile

Antigen Summary

This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with DIAPH1

  • diaphanous homolog 1 (Drosophila) (DIAPH1) antibody
  • diaphanous-related formin 1 (DIAPH1) antibody
  • diaphanous-related formin 1 (diaph1) antibody
  • diaphanous-related formin 1 (Diaph1) antibody
  • diaphanous homolog 1 (Drosophila) (diaph1) antibody
  • diaphanous homolog 1 (Drosophila) (Diap1) antibody
  • D18Wsu154e antibody
  • DFNA1 antibody
  • DIA1 antibody
  • Diap1 antibody
  • Diaph1 antibody
  • DIAPH2 antibody
  • DRF1 antibody
  • hDIA1 antibody
  • LFHL1 antibody
  • mKIAA4062 antibody
  • p140mDia antibody

Protein level used designations for DIAPH1

diaphanous homolog 1 (Drosophila) , diaphanous homolog 1 , diaphanous homolog 2 , protein diaphanous homolog 1 , protein diaphanous homolog 1-like , diaphanous-related formin-1 , mDIA1

GENE ID SPECIES
100684883 Canis lupus familiaris
700918 Macaca mulatta
786565 Bos taurus
733754 Xenopus (Silurana) tropicalis
100072186 Equus caballus
374040 Gallus gallus
307483 Rattus norvegicus
100457442 Pongo abelii
100478130 Ailuropoda melanoleuca
100562222 Anolis carolinensis
13367 Mus musculus
1729 Homo sapiens
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