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Discs, Large Homolog 4 (Drosophila) Proteins (DLG4)

DLG4 encodes a member of the membrane-associated guanylate kinase (MAGUK) family. Additionally we are shipping Discs, Large Homolog 4 (Drosophila) Antibodies (219) and Discs, Large Homolog 4 (Drosophila) Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DLG4 13385 Q62108
DLG4 29495 P31016
DLG4 1742 P78352
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Top Discs, Large Homolog 4 (Drosophila) Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,114.00
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DLG4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

More Proteins for Discs, Large Homolog 4 (Drosophila) (DLG4) Interaction Partners

Fruit Fly (Drosophila melanogaster) Discs, Large Homolog 4 (Drosophila) (DLG4) interaction partners

  1. Banderuola (Bnd) is a novel regulator of asymmetric cell division (ACD (show ACD Proteins)). The data place Bnd at the top of the hierarchy of the factors involved in ACD (show ACD Proteins), suggesting that its main function is mediating localization and function of Dlg tumor suppressor.

  2. The inactivation of cellular cortex polarization is the most likely target of dlg inactivation in mitosis.

  3. Loss of scrib, dlg and lgl had no effect on gonad formation, but Dlg and Scrib in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.

  4. Gliotactin and Discs large are co-regulated to maintain epithelial integrity.

  5. Hts (show APCDD1 Proteins) regulates Dlg targeting to the neuromuscular junction in muscle and the lateral membrane of epithelial cells.

  6. Electron microscopy reveals that during metamorphosis the subsynaptic reticulum vacuolizes in the early stages of synapse dismantling, concomitant with diffuse localization of Dlg.

  7. DlgS97-Metro-DLin-7-type complexes control the proper organization of a synaptic junction; findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization

  8. Study provide evidence that scrib and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib and dlg act in a common pathway to regulate PFC (show CFP Proteins) fate induction.

  9. integrins act through CaMKII activation to control the localization of dlg in the development of NMJ synaptic morphology

  10. conclude that Dlg/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts

Mouse (Murine) Discs, Large Homolog 4 (Drosophila) (DLG4) interaction partners

  1. Data indicate a contribution of D2 dopamine receptors to the effects of repetitive transcranial magnetic stimulation (rTMS) on postsynaptic density protein-95 (PSD-95) and cyclin-dependent kinase 5 (CDK5 (show CDK5 Proteins)) levels.

  2. Data show that in adult PSD-95 knockout mice, ocular dominance plasticity in visual cortex (V1) was preserved after a stroke lesion in somatosensory cortex (S1).

  3. adult mice lacking interleukin-1 receptor 1 (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus.

  4. Data demonstrate a role for SNAP-25 (show SNAP25 Proteins) in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity.

  5. Rph3A (show RPH3A Proteins) interacts with GluN2A (show GRIN2A Proteins) and PSD-95 forming a complex that regulates NMDARs stabilization at postsynaptic membranes.

  6. Egr-1 (show EGR1 Proteins) is involved in NMDAR (show GRIN1 Proteins)-mediated PSD-95 down-regulation and AMPAR endocytosis, a process important in the expression of long term depression

  7. Homer1a (show HOMER1 Proteins) may be a key neuroprotective endogenous molecule that protects against NMDA-induced neuronal injury by disassembling NR2B (show GRIN2B Proteins)-PSD95-nNOS (show NOS1 Proteins) complexes and reducing the membrane distribution of NR2B (show GRIN2B Proteins).

  8. Results identify PSD-95 in the infralimbic cortex as a critical mechanism supporting the durability of fear memories over time

  9. ephrin-B3 (show EFNB3 Proteins) specifies the synaptic localization of PSD-95 and likely links the synaptic stability of PSD-95 to changes in neuronal activity

  10. PSD-95 transcripts undergo polypyrimidine tract binding protein (show PTBP1 Proteins) (PTBP)-dependent alternative splicing of its pivotal exon 18 required to avoid nonsense-mediated decay

Human Discs, Large Homolog 4 (Drosophila) (DLG4) interaction partners

  1. Data demonstrate a role for SNAP-25 (show SNAP25 Proteins) in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity.

  2. Data indicate the very high affinities of the trimeric ligands to postsynaptic density protein 95 (PSD-95) PDZ domains.

  3. In this review, we focus on palmitoylation of PSD-95, which is a major postsynaptic scaffolding protein and makes discrete postsynaptic nanodomains in a palmitoylation-dependent manner and discuss a determinant role of local palmitoylation cycles

  4. An association was found between reduced PSD95 in the prefrontal cortex and cognitive impairment in patients with either dementia with Lewy bodies or Parkinson's disease dementia.

  5. Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 decrease after loss of synaptophysin (show SYP Proteins) and before neuronal loss in patients with Alzheimer's disease.

  6. The postsynaptic membrane protein PSD95 was increased in schizophrenia in CA3 (show CA3 Proteins) tissue, but not in CA1 (show CA1 Proteins) tissue.

  7. The crystal structures of the Dlg4 GK domain in complex with two phosphor-Lgl2 (show LLGL2 Proteins) peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg/Lgl complex formation.

  8. PSD-95 mRNA G-rich region folds into alternate G quadruplex conformations that coexist in equilibrium and miR (show MLXIP Proteins)-125a forms a stable complex with PSD-95 mRNA.

  9. Polymorphisms of DRD1 (show DRD1 Proteins), DLG4 and HOMER1 (show HOMER1 Proteins) are associated with opiate abuse.

  10. The PDZ1 domain of PSD-95 has a shallow binding pocket that accommodates a peptide ligand involving far fewer interactions and a micromolar affinity

Discs, Large Homolog 4 (Drosophila) (DLG4) Protein Profile

Protein Summary

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DLG4

  • discs large 1 (dlg1)
  • discs, large homolog 4 (dlg4)
  • lethal giant larvae homolog 1 (Drosophila) (DLG4)
  • discs, large homolog 4 (Drosophila) (DLG4)
  • discs, large (Drosophila) homolog 4 (dlg4)
  • discs, large homolog 4 (Drosophila) (Dlg4)
  • lethal giant larvae homolog 1 (Drosophila) (LLGL1)
  • 11 protein
  • anon-EST:Posey93 protein
  • anon-WO03040301.258 protein
  • anon-WO03040301.260 protein
  • anon-WO03040301.268 protein
  • CG1725 protein
  • CG1730 protein
  • CPD protein
  • d. lg.-1 protein
  • Discs-large protein
  • dlg protein
  • dlg-1 protein
  • dlg-A protein
  • Dlg1 protein
  • DLG4 protein
  • dlgA protein
  • Dlgh4 protein
  • dlgS97 protein
  • Dmel\\CG1725 protein
  • Drodlg protein
  • l(1)10Bf protein
  • l(1)bwn protein
  • l(1)d.lg-1 protein
  • l(1)d.lg.-1 protein
  • l(1)discs large protein
  • l(1)dlg protein
  • l(1)dlg-1 protein
  • l(1)dlg1 protein
  • l(1)G0276 protein
  • l(1)G0342 protein
  • l(1)G0456 protein
  • l(1)G19 protein
  • l(1)l.pr.-2 protein
  • l(1)L11 protein
  • l(1)lpr-2 protein
  • LLGL1 protein
  • misb protein
  • PSD-95 protein
  • psd95 protein
  • SAP-90 protein
  • Sap90 protein
  • SAP90A protein
  • SAP97 protein

Protein level used designations for DLG4

CG1725-PA , CG1725-PB , CG1725-PC , CG1725-PD , CG1725-PE , CG1725-PF , CG1725-PG , CG1725-PH , CG1725-PI , CG1725-PJ , CG1725-PK , CG1725-PL , CG1725-PM , CG1725-PN , CG1725-PO , CG1725-PP , CG1725-PQ , CG1725-PR , CG1725-PS , CG1725-PT , CG1725-PU , Disc-large , Discs-large , disc large , discs large , discslarge , disk large , dlg1-PA , dlg1-PB , dlg1-PC , dlg1-PD , dlg1-PE , dlg1-PF , dlg1-PG , dlg1-PH , dlg1-PI , dlg1-PJ , dlg1-PK , dlg1-PL , dlg1-PM , dlg1-PN , dlg1-PO , dlg1-PP , dlg1-PQ , dlg1-PR , dlg1-PS , dlg1-PT , dlg1-PU , lethal(1)benign wing imaginal disc neoplasm , lethal(1)discs large , lethal(1)discs-large , lethal(2)discs large , discs, large homolog 4 , postsynaptic density protein 95 , disks large homolog 4 , PSD-95 , PSD95/SAP90 , PSD-95 alpha 2b , PSD-95 beta , SAP-90 , discs large homolog 4 , synapse-associated protein 90 , synapse-associated protein SAP90 , Tax interaction protein 15 , post-synaptic density protein 95

GENE ID SPECIES
32083 Drosophila melanogaster
779559 Xenopus (Silurana) tropicalis
468444 Pan troglodytes
489462 Canis lupus familiaris
100137840 Bos taurus
405796 Danio rerio
13385 Mus musculus
29495 Rattus norvegicus
1742 Homo sapiens
100339587 Oryctolagus cuniculus
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