DLG4 Protein (His tag)

Catalog No. ABIN7318409

Product Details

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This DLG4 protein is labelled with His tag.

Purpose: Recombinant Human DLG4 Protein (His Tag)

Sequence: Met 1-Leu724

Characteristics: Recombinant Human Postsynaptic Density Protein 95 is produced by our E.coli expression system and the target gene encoding Met1-Leu724 is expressed with a 6His tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Alternative Name: DLG4 (DLG4 Products)

Synonyms: 11 Protein, CG1725 Protein, CG1730 Protein, CPD Protein, DLG Protein, DLG-A Protein, Discs-large Protein, Dlg Protein, Dlg-A Protein, Dlg1 Protein, DlgA Protein, Dmel\\CG1725 Protein, Drodlg Protein, PSD95 Protein, SAP97 Protein, anon-EST:Posey93 Protein, anon-WO03040301.258 Protein, anon-WO03040301.260 Protein, anon-WO03040301.268 Protein, d. lg.-1 Protein, dlg Protein, dlg-1 Protein, dlg-A Protein, dlgA Protein, dlgS97 Protein, l(1)10Bf Protein, l(1)G0276 Protein, l(1)G0342 Protein, l(1)G0456 Protein, l(1)G19 Protein, l(1)L11 Protein, l(1)bwn Protein, l(1)d.lg-1 Protein, l(1)d.lg.-1 Protein, l(1)discs large Protein, l(1)dlg Protein, l(1)dlg-1 Protein, l(1)dlg1 Protein, l(1)l.pr.-2 Protein, l(1)lpr-2 Protein, misb Protein, dlgh4 Protein, psd95 Protein, sap90 Protein, sap-90 Protein, LLGL1 Protein, Dlgh4 Protein, PSD-95 Protein, SAP90 Protein, SAP90A Protein, Sap90 Protein, SAP-90 Protein, DLG4 Protein, discs large 1 Protein, discs, large homolog 4 Protein, discs large MAGUK scaffold protein 4 Protein, discs, large homolog 4b (Drosophila) Protein, discs, large homolog 4 (Drosophila) Protein, dlg1 Protein, dlg4 Protein, DLG4 Protein, dlg4b Protein, Dlg4 Protein

Background:

Background: Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain,3 PDZ (DHR) domains and 1 SH3 domain. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.

Synonym: Disks large homolog 4, Postsynaptic density protein 95, PSD-95, Synapse-associated protein 90, SAP-90, SAP90, PSD95, DLG4

Molecular Weight: 81.9 kDa

UniProt: P78352

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity