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DVL3 is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. Additionally we are shipping DVL3 Proteins (2) and many more products for this protein.
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we demonstrate that normally ALFY (show WDFY3 Antibodies) attenuates the canonical Wnt (show WNT2 Antibodies) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 (show DVL1 Antibodies) or Dvl2 (show DVL2 Antibodies).
All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome.
data suggest that miR (show MLXIP Antibodies)-204-5p regulates adipogenesis by controlling DVL3 expression and subsequently inhibiting the activation of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
findings confirm that p38 (show CRK Antibodies) and PAX2 (show PAX2 Antibodies) are important for the Dvl-3 induced upregulation of p120ctn (show CTNND1 Antibodies)
Tumors that responded to IGFIR inhibition contain relatively lower levels of DVL3 protein than resistant tumors.
data (i) support previous the assumption that CK1 acts via phosphorylation of distinct residues as the activator as well as the shut-off signal of Wnt/beta-catenin signaling and (ii) suggest that CK1 acts on Dvl via different mechanism than Fzd5.
High expression of IGFBP7 (show IGFBP7 Antibodies) in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta (show TGFB1 Antibodies) and Wnt (show WNT2 Antibodies) signaling in a Smad2 (show SMAD2 Antibodies)/3-Dvl2 (show DVL2 Antibodies)/3-dependent manner.
Study showed an association of DVL-1 (show DVL1 Antibodies) and DVL-3 with Hirschsprung's disease.
AMPK (show PRKAA1 Antibodies) activators suppress cervical cancer cell growth by impairing DVL3 protein synthesis via AMPK (show PRKAA1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling and/or partially promoting the proteasomal degradation of DVL3
Dvl3 protein transduce signals via the Wnt (show WNT2 Antibodies) proteins non canonical pathways, namely via NFAT (show NFATC1 Antibodies) protein and Src kinase (show CSK Antibodies) and novel NPM (show NPM1 Antibodies)-ALK (show ALK Antibodies) interacting proteins and possibly NPM (show NPM1 Antibodies)-ALK (show ALK Antibodies) substrates.
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
DSH homolog 3
, dishevelled 3 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 3
, segment polarity protein dishevelled homolog DVL-3