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Distal-Less Homeobox 5 Proteins (DLX5)

DLX5 encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. Additionally we are shipping Distal-Less Homeobox 5 Antibodies (93) and Distal-Less Homeobox 5 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DLX5 296499  
DLX5 1749 P56178
DLX5 13395 P70396
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Top Distal-Less Homeobox 5 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days

DLX5 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
Mouse (Murine)

More Proteins for Distal-Less Homeobox 5 (DLX5) Interaction Partners

Xenopus laevis Distal-Less Homeobox 5 (DLX5) interaction partners

  1. Retinoic acid treatment leads to a progressive loss of Dlx5 and Dlx6 expression in the first pharyngeal arch.

Human Distal-Less Homeobox 5 (DLX5) interaction partners

  1. These data indicate that certain missense mutations diminish the ability of the Dlx5 homeodomain to recognize and bind target DNAs, and they likely destabilize the formation of functional complexes.

  2. In cells grown on titanium support, DLX5 and RUNX1 (show RUNX1 Proteins) were respectively upregulated (+3.12-fold) and downregulated (-2.14-fold)

  3. Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.

  4. Heterozygous DLX5 nonsense mutation c.G115T(p.E39X) associated with isolated split-hand/foot malformation with reduced penetrance and variable expressivity in two unrelated Polish families.

  5. A novel heterozygous mutation in exon 3 of DLX5 found in the family members with SHFM1 (show SHFM1 Proteins) phenotype.

  6. Genome sequencing of the deletion breakpoints showed that the DLX5 and DLX6 genes are disomic but the putative DYNC1I1 (show DYNC1I1 Proteins) exon 15 and 17 enhancers are deleted.

  7. The duplicated region harbors only DLX5 and DLX6, which are known for their role in SHFM1 (show SHFM1 Proteins).

  8. The strongest evidence for altered methylation patterns in shiftworkers was observed for DLX5 gene.

  9. Cyclic tensile stress may induce differentiation of periodontal ligament stem cells towards mineralized tissue cells by promoting Dlx5 mRNA expression and decreasing Msx2 expression.

  10. Two patients that have in common a p63-Dlx5/Dlx6 pathway dysregulation.

Pig (Porcine) Distal-Less Homeobox 5 (DLX5) interaction partners

  1. Imprinting analysis shows that DLX5 is maternally expressed in some organs and tissues but not imprinted in others.

Mouse (Murine) Distal-Less Homeobox 5 (DLX5) interaction partners

  1. Dlx5 and Dlx6 expression determines uterine architecture and adenogenesis and is needed for implantation

  2. The results presented here indicate that loss of Dlx5 causes a down-modulation of miR (show MLXIP Proteins)-9 and of miR (show MLXIP Proteins)-200-class, which results in the over-expression of the Foxg1 (show FOXG1 Proteins) protein.

  3. Lck (show LCK Proteins)-Dlx5 mice develop T-ALLs that consistently acquire overexpression of Myc (show MYC Proteins) and activation of Akt (show AKT1 Proteins).

  4. Study demonstrated a novel role of miR (show MLXIP Proteins)-124 and Dlx5 in regulating the differentiation of mesenchymal stem cells toward the myogenic lineage, that is, miR (show MLXIP Proteins)-124 inhibits myogenic differentiation partially through targeting Dlx5 expression.

  5. Mash1 (show ASCL1 Proteins) is required for the expression of GAD67 (show GAD1 Proteins) and Dlx5 in taste bud cells.

  6. Dlx5 and Mef2 (show MEF2C Proteins) directly bound to the runx2 (show RUNX2 Proteins) enhancer, and the binding sites were required for the osteoblast-specific expression

  7. the prethalamic factors Dlxs upregulated by Ascl1 (show ASCL1 Proteins)/Helt (show HELT Proteins) deficiency play unique roles in regulating thalamic progenitor specification.

  8. Results show that DLX5, p63 (show CKAP4 Proteins), Pin1 (show PIN1 Proteins) and FGF8 (show FGF8 Proteins) participate to the same time- and location-restricted regulatory loop essential for apical ectodermal ridge stratification, hence for normal patterning and skeletal morphogenesis of the limb buds.

  9. The Edn1/Ednra signaling regulates neural crest differentiation to ensure the proper patterning of pharyngeal arch arteries, which is independent of the mechanism mediated by Dlx5/Dlx6.

  10. Data show that Dlx5 and Msx2 play a critical role in controlling cranial neural tube morphogenesis by regulating cell adhesion via the ephrinA5 and EphA7 (show EPHA7 Proteins) pathway.

Zebrafish Distal-Less Homeobox 5 (DLX5) interaction partners

  1. Data indicate that retinoic acid (RA) induces the expression patterns of genes normally expressed in the posterior tooth-forming region, such as pitx2 (show PITX2 Proteins) and dlx2b.

Distal-Less Homeobox 5 (DLX5) Protein Profile

Protein Summary

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.

Gene names and symbols associated with Distal-Less Homeobox 5 Proteins (DLX5)

  • distal-less homeobox 5 (dlx5)
  • distal-less homeobox 5 (DLX5)
  • distal-less homeobox 2 (Dlx2)
  • distal-less homeobox 5 (Dlx5)
  • distal-less homeobox gene 2b (dlx2b)
  • AI385752 protein
  • dll3 protein
  • dlx5 protein
  • MGC69418 protein
  • RDLX protein
  • SHFM1D protein
  • X-dll3 protein

Protein level used designations for Distal-Less Homeobox 5 Proteins (DLX5)

distal-less homeobox 5 , DLX-5 , homeobox Dlx5 , homeobox protein DLX-2 , XDLL-3 , homeobox protein DLL-3 , putative transcription factor DLL3 , distal-less homeo box 5 , homeobox protein DLX-5 , split hand/foot malformation type 1 with sensorineural hearing loss , cDlx , DLX-3 , homeobox protein DLX-3 , distal-less homeobox protein 5 , distal-less homeobox gene 5 , distal-less homeobox protein 2b , homeobox protein Dlx2b

447997 Xenopus (Silurana) tropicalis
463554 Pan troglodytes
697853 Macaca mulatta
296499 Rattus norvegicus
399265 Xenopus laevis
1749 Homo sapiens
482313 Canis lupus familiaris
100286863 Sus scrofa
507415 Bos taurus
13395 Mus musculus
373969 Gallus gallus
25431 Rattus norvegicus
100008630 Oryctolagus cuniculus
101119298 Ovis aries
30557 Danio rerio
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