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DCX encodes a member of the doublecortin family. Additionally we are shipping Doublecortin Antibodies (158) and Doublecortin Kits (37) and many more products for this protein.
Showing 9 out of 12 products:
Human Doublecortin Protein expressed in Escherichia coli (E. coli) - ABIN2005738
des Portes, Pinard, Billuart, Vinet, Koulakoff, Carrié, Gelot, Dupuis, Motte, Berwald-Netter, Catala, Kahn, Beldjord, Chelly: A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. in Cell 1998
Show all 3 references for ABIN2005738
Human Doublecortin Protein expressed in Wheat germ - ABIN1351244
Jiang, Brackeva, Stangé, Verhaeghen, Costa, Couillard-Després, Rotheneichner, Aigner, Van Schravendijk, Pipeleers, Ling, Gorus, Martens: LC-MS/MS identification of doublecortin as abundant beta cell-selective protein discharged by damaged beta cells in vitro. in Journal of proteomics 2013
From this family, we conclude that a DCX mutation causes a pleiotropic phenotype in the female even if X chromosome inactivation pattern is not skewed, and the novel missense mutation in DCX produced relatively mild dysfunction of the doublecortin protein.
We identified a novel DCX mutation c.785A > G, p.Asp262Gly in a family with X-linked lissencephaly and subcortical band heterotopia
In high-risk metastatic Neuroblastoma (show ARHGEF16 Proteins), TH and DCX mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.
Results point to a critical role of doublecortin in the formation of the neuromuscular junctions.
DCX-positive cells occur in a wide range of hypothalamic nuclei in humans, mice and sheep.
human DCX protein was expressed in human adipose stem cells, collagen II was decreased while aggrecan (show ACAN Proteins), matrilin 2 (show MATN2 Proteins), and GDF5 (show GDF5 Proteins) were increased during the 14-day pellet culture.
We propose that DCDC2 (show DCDC2 Proteins) is a tumor suppressor gene of HCC (show FAM126A Proteins).
in utero doublecortin knockdown, but not knockout, shows a neocortical neuronal migration phenotype.
Immunoblots revealed that depressed subjects displayed increased expression of doublecortin.
coexpression of DCX and SPARC (show SPARC Proteins) collaboratively diminished radioresistance of glioma cells.
Findings demonstrate the direct requirement of ADAM10 (show ADAM10 Proteins) in cortical radial migration and reveal the underlying mechanism by linking ADAM10 (show ADAM10 Proteins)-initiated regulated intramembrane proteolysis of Notch (show NOTCH1 Proteins) to the regulation of microtubule cytoskeleton through transcriptional control of Dcx expression
Dcx is a new marker for the Pax7 (show PAX7 Proteins)(+)MyoD (show MYOD1 Proteins)(-) subpopulation, which contributes to myofiber maturation during muscle regeneration.
DCX-positive cells resembling immature and developing neurons were found in mice and sheep and human hypothalamus.
we showed that miR (show MLXIP Proteins)-29a directly regulated its target protein Doublecortin (DCX) expression, which further modulated axon branching in primary culture.
Cdk5 (show CDK5 Proteins) and its substrates, Dcx and p27kip1 (show CDKN1B Proteins), regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.
Doublecortin knockout mice show lamination defects of the hippocampal pyramidal cell layer largely restricted to the CA3 (show CA3 Proteins) region.
Dcx protein- and mRNA-levels reflected changes in neurogenesis
DCX is dispensable for the development of new neurons in adult mice
results indicate that immature DCX-expressing neurons are required for successful acquisition of spatial learning, as well as reversal learning, but are not necessary for the retrieval of stored long-term memories.
In axons from mice mutant for Dcx, widespread differences are found in actin-associated proteins as compared with wild-type axons
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
doublecortex; lissencephaly, X-linked (doublecortin)
, neuronal migration protein doublecortin
, lissencephaly, X-linked (doublecortin)