Doublecortin Proteins (DCX)

DCX encodes a member of the doublecortin family. Additionally we are shipping Doublecortin Antibodies (162) and Doublecortin Kits (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DCX 1641 O43602
DCX 13193 O88809
DCX 84394  
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Top Doublecortin Proteins at

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 20 to 21 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Chicken His tag 50 μg Log in to see 13 to 16 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Mouse S tag,His tag   100 μg Log in to see 15 to 18 Days
HOST_Escherichia coli (E. coli) Chicken Un-conjugated   50 μg Log in to see 2 to 3 Days

DCX Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
Rat (Rattus)

Top referenced Doublecortin Proteins

  1. Human Doublecortin Protein expressed in Escherichia coli (E. coli) - ABIN2005738 : des Portes, Pinard, Billuart, Vinet, Koulakoff, Carrié, Gelot, Dupuis, Motte, Berwald-Netter, Catala, Kahn, Beldjord, Chelly: A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. in Cell 1998 (PubMed)
    Show all 3 references for 2005738

  2. Human Doublecortin Protein expressed in Wheat germ - ABIN1351244 : Jiang, Brackeva, Stangé, Verhaeghen, Costa, Couillard-Després, Rotheneichner, Aigner, Van Schravendijk, Pipeleers, Ling, Gorus, Martens: LC-MS/MS identification of doublecortin as abundant beta cell-selective protein discharged by damaged beta cells in vitro. in Journal of proteomics 2013 (PubMed)

More Proteins for Doublecortin (DCX) Interaction Partners

Human Doublecortin (DCX) interaction partners

  1. this suggests that the microtubule-interacting doublecortin domain observed in cryo-electron micrographs is the C-terminal domain rather than the N-terminal one.

  2. From this family, we conclude that a DCX mutation causes a pleiotropic phenotype in the female even if X chromosome inactivation pattern is not skewed, and the novel missense mutation in DCX produced relatively mild dysfunction of the doublecortin protein.

  3. We identified a novel DCX mutation c.785A > G, p.Asp262Gly in a family with X-linked lissencephaly and subcortical band heterotopia

  4. In high-risk metastatic Neuroblastoma (show ARHGEF16 Proteins), TH and DCX mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.

  5. Results point to a critical role of doublecortin in the formation of the neuromuscular junctions.

  6. DCX-positive cells occur in a wide range of hypothalamic nuclei in humans, mice and sheep.

  7. human DCX protein was expressed in human adipose stem cells, collagen II was decreased while aggrecan (show ACAN Proteins), matrilin 2 (show MATN2 Proteins), and GDF5 (show GDF5 Proteins) were increased during the 14-day pellet culture.

  8. We propose that DCDC2 (show DCDC2 Proteins) is a tumor suppressor gene of HCC (show FAM126A Proteins).

  9. in utero doublecortin knockdown, but not knockout, shows a neocortical neuronal migration phenotype.

  10. Immunoblots revealed that depressed subjects displayed increased expression of doublecortin.

Mouse (Murine) Doublecortin (DCX) interaction partners

  1. The regulation axis from microRNA-128-3p to doublecortin is critical for hippocampus-related contextual learning not only in wild type, but also in mice infused with Abeta (show APP Proteins)-42.

  2. Findings demonstrate the direct requirement of ADAM10 (show ADAM10 Proteins) in cortical radial migration and reveal the underlying mechanism by linking ADAM10 (show ADAM10 Proteins)-initiated regulated intramembrane proteolysis of Notch (show NOTCH1 Proteins) to the regulation of microtubule cytoskeleton through transcriptional control of Dcx expression

  3. Dcx is a new marker for the Pax7 (show PAX7 Proteins)(+)MyoD (show MYOD1 Proteins)(-) subpopulation, which contributes to myofiber maturation during muscle regeneration.

  4. DCX-positive cells resembling immature and developing neurons were found in mice and sheep and human hypothalamus.

  5. we showed that miR (show MLXIP Proteins)-29a directly regulated its target protein Doublecortin (DCX) expression, which further modulated axon branching in primary culture.

  6. Cdk5 (show CDK5 Proteins) and its substrates, Dcx and p27kip1 (show CDKN1B Proteins), regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.

  7. Doublecortin knockout mice show lamination defects of the hippocampal pyramidal cell layer largely restricted to the CA3 (show CA3 Proteins) region.

  8. Dcx protein- and mRNA-levels reflected changes in neurogenesis

  9. DCX is dispensable for the development of new neurons in adult mice

  10. results indicate that immature DCX-expressing neurons are required for successful acquisition of spatial learning, as well as reversal learning, but are not necessary for the retrieval of stored long-term memories.

Doublecortin (DCX) Protein Profile

Protein Summary

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Doublecortin Proteins (DCX)

  • doublecortin (DCX)
  • doublecortin (Dcx)
  • 18C15.5 protein
  • DBCN protein
  • Dbct protein
  • DC protein
  • DCX protein
  • LISX protein
  • SCLH protein
  • XLIS protein

Protein level used designations for Doublecortin Proteins (DCX)

doublecortex; lissencephaly, X-linked (doublecortin) , doublecortin , doublecortex , doublin , lis-X , lissencephalin-X , neuronal migration protein doublecortin , lissencephaly, X-linked (doublecortin)

100058909 Equus caballus
494212 Felis catus
473733 Pan troglodytes
752002 Taeniopygia guttata
1641 Homo sapiens
13193 Mus musculus
84394 Rattus norvegicus
374242 Gallus gallus
787968 Bos taurus
612950 Canis lupus familiaris
100713827 Cavia porcellus
101109861 Ovis aries
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