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Dual Oxidase 2 Proteins (DUOX2)

The protein encoded by DUOX2 is a glycoprotein and a member of the NADPH oxidase family. Additionally we are shipping DUOX2 Antibodies (37) and DUOX2 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DUOX2 50506 Q9NRD8
Mouse DUOX2 DUOX2 214593  
Rat DUOX2 DUOX2 79107 Q9ES45
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Top DUOX2 Proteins at

Showing 2 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days

DUOX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Dual Oxidase 2 (DUOX2) Interaction Partners

Human Dual Oxidase 2 (DUOX2) interaction partners

  1. The high prevalence of DUOX2 mutations in this cohort of children with Congenial hypothyroidism appears striking and surprising. The clinical implications were discussed.

  2. study expanded the mutational spectrum of the DUOX2 and thyroglobulin (show TG Proteins) genes and provided the best estimation of the DUOX2 mutation rate (29%) for congenital hypothyroidism/subclinical congenital hypothyroidism patients in Guangxi Zhuang Autonomous Region of China

  3. Seven different recurrent mutations [p.G488R (n=13), p.A649E (n=3), p.R885Q (n=3), p.I1080T (n=2), and p.A1206T (n=2) in DUOX2; p.Y138X (n=9) in DUOXA2 (show DUOXA2 Proteins)) were identified as the mutations underlying congenital hypothyroidism.

  4. Transient congenital hypothyroidism is caused by compound heterozygous mutations affecting the NADPH-oxidase (show NOX1 Proteins) domain of DUOX2.

  5. the house dust mite-dependent TLR2-Duox2 signalling axis promotes NF-kappaB (show NFKB1 Proteins) activation, which induces IL-8 (show IL8 Proteins) and CCL20 (show CCL20 Proteins) production and mediates epidermal keratinocyte inflammation

  6. Results identified 2 mutations in DUOX2 gene from patient with congenital hypothyroidism and report new cryptic splicing sites in the intron 17 and exon 18.

  7. Decreased Panx1 (show PANX1 Proteins) function is a response to cell acidification mediated by IFN-gamma-induced (show SAMHD1 Proteins) up-regulation of Duox2.

  8. inactivating mutations in the DUOXA2 (show DUOXA2 Proteins) (p.Y246X) and DUOX2 (p.R885Q) genes were identified in a set of dizygotic twins with congenital hypothyroidism

  9. Prevalence of DUOX2 pathogenic variants is 29% among patients with congenital hypothyroidism in Guangxi, China. Monoallelic and biallelic DUOX2 variants are associated with transient, while triallelic variants are associated with permanent disease.

  10. The prognosis of Japanese patients with DUOX2 defects was usually transient Congenital hypothyroidism. Delayed improvement of thyroglobulin (show TG Proteins) indicates that these patients have subclinical hypothyroidism.

Pig (Porcine) Dual Oxidase 2 (DUOX2) interaction partners

  1. the dual oxidase 2 N-terminal region is targeted to the plasma membrane

Mouse (Murine) Dual Oxidase 2 (DUOX2) interaction partners

  1. DUOX2 (show DUOX1 Proteins) regulates interactions between the intestinal microbiota and the mucosa to maintain immune homeostasis in mice.

  2. these data indicate that the gut (show GUSB Proteins) microbiota uses two distinct signaling pathways to induce Duox2 (show DUOX1 Proteins) expression in the ileum and colon epithelium.

  3. Data suggest that proteinase-activated receptor 2 (show F2RL1 Proteins) activation leads to up-regulation of the dual oxidase-2 (show DUOX1 Proteins)/reactive oxygen species pathway in airway epithelial cells (AECs).

  4. DUOX2 (show DUOX1 Proteins)-generated ROS (show ROS1 Proteins) induce AEC death.

  5. a spontaneously generated valine 674-to-glycine mutation of murine Duox2 (show DUOX1 Proteins) results in a translocation defect and complete loss of function that explains the severe congenital hypothyroid phenotype of the thyd/thyd mouse strain

  6. DUOX2 (show DUOX1 Proteins) plays pivotal roles in TLR5 (show TLR5 Proteins)-dependent inflammatory response of nasal airway epithelium.

  7. DUOX2 and NOD2 cooperatively facilitate antibacterial action.

DUOX2 Protein Profile

Protein Summary

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.

Gene names and symbols associated with Dual Oxidase 2 Proteins (DUOX2)

  • dual oxidase 2 (DUOX2)
  • dual oxidase 2 (Duox2)
  • A430065P05Rik protein
  • LNOX2 protein
  • NOXEF2 protein
  • P138-TOX protein
  • TDH6 protein
  • Thox2 protein

Protein level used designations for Dual Oxidase 2 Proteins (DUOX2)

dual oxidase 2 , dual oxidase 2-like , NADH/NADPH thyroid oxidase p138-tox , NADPH oxidase/peroxidase DUOX2 , NADPH thyroid oxidase 2 , dual oxidase-like domains 2 , flavoprotein NADPH oxidase , large NOX 2 , long NOX 2 , nicotinamide adenine dinucleotide phosphate oxidase , p138 thyroid oxidase , thyroid oxidase 2 , NADH/NADPH thyroid oxidase THOX2

100070566 Equus caballus
427482 Gallus gallus
453395 Pan troglodytes
785698 Bos taurus
100445893 Pongo abelii
100462743 Ovis aries
50506 Homo sapiens
403719 Canis lupus familiaris
397060 Sus scrofa
214593 Mus musculus
79107 Rattus norvegicus
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