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DUOX2 Products

(Dual Oxidase 2 (DUOX2))
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008].

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Featured DUOX2 Categories

DUOX2 Antibodies

High quality antibodies with extensive validation data.

DUOX2 ELISA Kits

Reliable ELISA kits for a wide range of species.

DUOX2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DUOX2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, FACS
Validations
  • (2)
Cat. No. ABIN655174
Quantity 400 μL
Datasheet Datasheet
Reactivity Dog, Human, Mouse, Pig, Rat
Application WB
Validations
  • (3)
  • (1)
Cat. No. ABIN540738
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7150690
Quantity 100 μL
Datasheet Datasheet

Recommended DUOX2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966425
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955461
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955462
Quantity 96 tests
Datasheet Datasheet

Recommended DUOX2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3079169
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3079170
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3079168
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our DUOX2 products

Dyikanov, Vasiluev, Rysenkova, Aleksandrushkina, Tyurin-Kuzmin, Kulebyakin, Rubtsov, Shmakova, Evseeva, Balatskiy, Semina, Rostovtseva, Makarevich, Karagyaur: "Optimization of CRISPR/Cas9 Technology to Knock Out Genes of Interest in Aneuploid Cell Lines." in: Tissue engineering. Part C, Methods, Vol. 25, Issue 3, pp. 168-175, (2019) (PubMed).

Jafari, Kim, Park, Li, Jang, Morris, Park, Huang: "CRISPR-Cas9 Mediated NOX4 Knockout Inhibits Cell Proliferation and Invasion in HeLa Cells." in: PLoS ONE, Vol. 12, Issue 1, pp. e0170327, (2017) (PubMed).

Tyurin-Kuzmin, Zhdanovskaya, Sukhova, Sagaradze, Albert, Ageeva, Sharonov, Vorotnikov, Tkachuk: "Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF." in: PLoS ONE, Vol. 11, Issue 4, pp. e0154157, (2016) (PubMed).

Wakatsuki, Furuno, Ohshima, Araki: "Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration." in: The Journal of cell biology, Vol. 211, Issue 4, pp. 881-96, (2015) (PubMed).

Nguyen, Parekh, Chang, Sharma, Carrier: "Contribution of Dual Oxidase 2 (DUOX2) to Hyper-Radiosensitivity in Human Gastric Cancer Cells." in: Radiation research, Vol. 184, Issue 2, pp. 151-60, (2015) (PubMed).

MacFie, Poulsom, Parker, Warnes, Boitsova, Nijhuis, Suraweera, Poehlmann, Szary, Feakins, Jeffery, Harper, Jubb, Lindsay, Silver: "DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid." in: Inflammatory bowel diseases, Vol. 20, Issue 3, pp. 514-24, (2014) (PubMed).

Harper, Xu, Eiserich, Chen, Kao, Thai, Setiadi, Wu: "Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium." in: FEBS letters, Vol. 579, Issue 21, pp. 4911-7, (2005) (PubMed).

Wang, De Deken, Milenkovic, Song, Pirson, Dumont, Miot: "Identification of a novel partner of duox: EFP1, a thioredoxin-related protein." in: The Journal of biological chemistry, Vol. 280, Issue 4, pp. 3096-103, (2005) (PubMed).

Morand, Chaaraoui, Kaniewski, Dème, Ohayon, Noel-Hudson, Virion, Dupuy: "Effect of iodide on nicotinamide adenine dinucleotide phosphate oxidase activity and Duox2 protein expression in isolated porcine thyroid follicles." in: Endocrinology, Vol. 144, Issue 4, pp. 1241-8, (2003) (PubMed).

De Deken, Wang, Many, Costagliola, Libert, Vassart, Dumont, Miot: "Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family." in: The Journal of biological chemistry, Vol. 275, Issue 30, pp. 23227-33, (2000) (PubMed).

Synonyms and alternative names related to DUOX2

dual oxidase 2 (DUOX2), dual oxidase 2 (Duox2), A430065P05Rik, LNOX2, NOXEF2, P138-TOX, TDH6, THOX2, Thox2

Protein level used designations for DUOX2

  • dual oxidase 2
  • dual oxidase 2-like
  • NADH/NADPH thyroid oxidase p138-tox
  • NADPH oxidase/peroxidase DUOX2
  • NADPH thyroid oxidase 2
  • dual oxidase-like domains 2
  • flavoprotein NADPH oxidase
  • large NOX 2
  • long NOX 2
  • nicotinamide adenine dinucleotide phosphate oxidase
  • p138 thyroid oxidase
  • thyroid oxidase 2
  • NADH/NADPH thyroid oxidase THOX2
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