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Dual Specificity Phosphatase 1 Proteins (DUSP1)

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Additionally we are shipping DUSP1 Antibodies (115) and DUSP1 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DUSP1 1843 P28562
DUSP1 19252 P28563
DUSP1 114856 Q64623
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Top DUSP1 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

DUSP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Dual Specificity Phosphatase 1 (DUSP1) Interaction Partners

Human Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. LPS (show IRF6 Proteins) tolerance interferes with TLR4 (show TLR4 Proteins) signaling by inhibiting Lyn (show LYN Proteins) and c-Src (show SRC Proteins) phosphorylation and their recruitment to TLR4 (show TLR4 Proteins), while increasing the phosphatase activity and expression of PP2A (show PPP2R4 Proteins), PTPN22 (show PTPN22 Proteins), PTP1B (show PTPN1 Proteins) and MKP1.

  2. This study shows that RIG-I (show DDX58 Proteins) activation results in MKP-1-mediated inhibition of cell proliferation in melanoma cells via controlling the p38 (show CRK Proteins)-HSP27 (show HSPB1 Proteins), c-Jun (show JUN Proteins) and rpS6 (show RPS6 Proteins) pathways

  3. In E1a (show BCKDHA Proteins) expressing non-small cell lung carcinoma cells, upregulation of MKP1 and the subsequent p38MAPK (show MAPK14 Proteins) inhibition is required for the induction of chemosensitivity to cisplatin.

  4. The heparin effects on TNFalpha (show TNF Proteins)-induced stress fiber formation and Map kinase (show MAPK1 Proteins) signaling depend on increased DUSP1 expression.

  5. evidence of association between depressive symptom severity and increasing serum MKP-1 levels in women, and decreasing T levels in perimenopausal women.

  6. MKP-1 can attenuate tamoxifen-induced cell death through inhibiting the JNK (show MAPK8 Proteins) signal pathway.

  7. Progesterone acts via GR to drive MKP-1 expression, which in turn inhibits IL-1beta (show IL1B Proteins)-dependent c-Jun (show JUN Proteins) activation and COX-2 expression.

  8. Data show that sorafenib inhibited microRNA miR (show MLXIP Proteins)-101 expression and enhanced dual specificity phosphatase 1 (DUSP1) expression and lowered transforming growth factor beta I (TGF-beta (show TGFB1 Proteins)) release in M2 macrophage, slowing macrophage-driven hepatocarcinoma.

  9. DUSP1 overexpression and inhibition of MAPKs prevented IL1B (show IL1B Proteins)-induced expression of ZFP36 (show ZFP36 Proteins), this was associated with increased TNF (show TNF Proteins) mRNA expression at 6 h, an effect that was predominantly due to elevated transcription.

  10. MKP-1 is a MAPK (show MAPK1 Proteins) deactivator; thus, by controlling p38 MAPK (show MAPK14 Proteins) phosphorylation status in a temporally distinct manner, MKP-1 ensures that TTP (show ADAMTS13 Proteins) is expressed and made functional at precisely the correct time to repress cytokine expression.

Mouse (Murine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. A2AR (show ADORA2A Proteins) signaling regulates both basal and LPS (show TLR4 Proteins)-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.

  2. these data suggest an important role for DUSPs in regulating MAPK (show MAPK1 Proteins) dephosphorylation, with an emphasis on DUSP1, during early adipogenesis

  3. Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age.

  4. Nr4a1 (show NR4A1 Proteins) induction is dependent on ERK1/2 and that MKP-1 negatively regulates this induction.

  5. MKP-1 negatively regulates chemokine (show CCL1 Proteins)-driven osteoclast formation and subsequent bone resorption in response to LPS (show TLR4 Proteins) stimulation

  6. results suggest that the p38alpha (show MAPK14 Proteins)-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells.

  7. DUSP1 and tristetraprolin (show ZFP36 Proteins) cooperate to regulate macrophage responses to lipopolysaccharide.

  8. MKP-1 regulated the expression of MMP-12 (show MMP12 Proteins).

  9. CYLD (show CYLD Proteins) negatively regulates nontypeable Haemophilus influenzae-induced IL-8 (show IL8 Proteins) expression via MKP-1-dependent inhibition of ERK (show EPHB2 Proteins).

  10. Ozone exposure decreased the protein expression of MKP-1 in an asthma model.

Cow (Bovine) Dual Specificity Phosphatase 1 (DUSP1) interaction partners

  1. MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2-mediated aldosterone production in response to the hormone.

DUSP1 Protein Profile

Protein Summary

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Gene names and symbols associated with DUSP1

  • dual specificity phosphatase 1 (DUSP1)
  • dual specificity phosphatase 1 (dusp1)
  • dual specificity phosphatase 1 (Dusp1)
  • 3CH134 protein
  • cb269 protein
  • CL100 protein
  • DUSP1 protein
  • erp protein
  • HVH1 protein
  • id:ibd2586 protein
  • mkp-1 protein
  • Mkp1 protein
  • PTPN10 protein
  • Ptpn16 protein
  • sb:cb269 protein
  • U19515 protein
  • wu:fd19g02 protein
  • wu:fe50g09 protein
  • zgc:55920 protein

Protein level used designations for DUSP1

dual specificity protein phosphatase 1 , dual specificity phosphatase 1 , mkp-1 , MAP kinase phosphatase 1 , dual specificity protein phosphatase hVH1 , mitogen-activated protein kinase phosphatase 1 , protein-tyrosine phosphatase CL100 , serine/threonine specific protein phosphatase , mitogen-activated protein kinase phosphatase-1 , protein tyrosine phosphatase, non-receptor type 16 , protein-tyrosine phosphatase 3CH134 , protein-tyrosine phosphatase ERP , 3CH134/CL100 PTPase , MAP kinase phosphatase-1 , mitogen-activated protein (MAP) kinase phosphatase-1 , oxidative stress-inducible protein tyrosine phosphatase , protein tyrosine phosphatase non-receptor type 16 , protein-tyrosine phosphatase non-receptor type 16 , MAPK phosphatase 1

374192 Gallus gallus
471742 Pan troglodytes
100219518 Taeniopygia guttata
100340993 Oryctolagus cuniculus
406340 Danio rerio
1843 Homo sapiens
19252 Mus musculus
114856 Rattus norvegicus
489117 Canis lupus familiaris
539175 Bos taurus
100522469 Sus scrofa
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