DUSP1 Products
(Dual Specificity Phosphatase 1 (DUSP1))
Categories
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008].
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Featured DUSP1 Categories
DUSP1 Antibodies
High quality antibodies with extensive validation data.
DUSP1 ELISA Kits
Reliable ELISA kits for a wide range of species.
DUSP1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DUSP1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (5)
Cat. No.
ABIN184638
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (3)
- (3)
Cat. No.
ABIN735368
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (3)
Cat. No.
ABIN515099
Quantity
100 μg
Datasheet
Datasheet
Recommended DUSP1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955464
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955465
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381321
Quantity
96 tests
Datasheet
Datasheet
Recommended DUSP1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352094
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352096
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3079130
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our DUSP1 products
: "Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity." in: Frontiers in pharmacology, Vol. 8, pp. 653, (2017) (PubMed).: "Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis." in: Oncotarget, Vol. 7, Issue 2, pp. 2009-21, (2016) (PubMed).
: "Transduction of Functionally Contrasting Signals by Two Mycobacterial PPE Proteins Downstream of TLR2 Receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 5, pp. 1776-87, (2016) (PubMed).
: "Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammation in Human Ovarian Granulosa Cells." in: International journal of molecular sciences, Vol. 17, Issue 8, (2016) (PubMed).
: "MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity." in: American journal of physiology. Endocrinology and metabolism, pp. ajpendo.00577.2013, (2014) (PubMed).
: "Progesterone receptor inhibits proliferation of human breast cancer cells via induction of MAPK phosphatase 1 (MKP-1/DUSP1)." in: The Journal of biological chemistry, Vol. 286, Issue 50, pp. 43091-102, (2011) (PubMed).
: "Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival." in: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4117-24, (2005) (PubMed).
: "Role of CL-100, a dual specificity phosphatase, in thrombin-induced endothelial cell activation." in: The Journal of biological chemistry, Vol. 279, Issue 45, pp. 46678-85, (2004) (PubMed).
: "Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role." in: Molecular pharmacology, Vol. 66, Issue 6, pp. 1478-90, (2004) (PubMed).
: "The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts." in: Oncogene, Vol. 8, Issue 7, pp. 2015-20, (1993) (PubMed).
Synonyms and alternative names related to DUSP1
dual specificity phosphatase 1 (DUSP1), dual specificity phosphatase 1 (Dusp1), dual specificity phosphatase 1 (dusp1), dual specificity phosphatase 1 S homeolog (dusp1.S), 3CH134, cb269, CL100, DUSP1, erp, HVH1, id:ibd2586, MKP-1, mkp-1, MKP1, Mkp1, PTPN10, Ptpn16, sb:cb269, U19515, wu:fd19g02, wu:fe50g09, XCL100, zgc:55920Protein level used designations for DUSP1
- MAP kinase phosphatase 1
- dual specificity protein phosphatase 1
- dual specificity protein phosphatase hVH1
- mitogen-activated protein kinase phosphatase 1
- protein-tyrosine phosphatase CL100
- serine/threonine specific protein phosphatase
- 3CH134/CL100 PTPase
- MAP kinase phosphatase-1
- mitogen-activated protein (MAP) kinase phosphatase-1
- oxidative stress-inducible protein tyrosine phosphatase
- protein tyrosine phosphatase non-receptor type 16
- protein tyrosine phosphatase, non-receptor type 16
- protein-tyrosine phosphatase non-receptor type 16
- dual specificity phosphatase 1
- mitogen-activated protein kinase phosphatase-1
- protein-tyrosine phosphatase 3CH134
- protein-tyrosine phosphatase ERP
- mkp-1
- MAPK phosphatase 1
- LOW QUALITY PROTEIN: dual specificity protein phosphatase 1
- MAP kinase phosphatase XCL100(beta) protein
- XCL100-beta
- dual specificity protein phosphatase 1-B
- dusp1-b
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