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anti-Dynactin 1 (DCTN1) Antibodies

DCTN1 encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Additionally we are shipping Dynactin 1 Proteins (3) and Dynactin 1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DCTN1 1639 Q14203
DCTN1 13191 O08788
DCTN1 29167 P28023
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Top anti-Dynactin 1 Antibodies at

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
Human Goat Un-conjugated IHC (p), IHC, ELISA, WB ABIN249648 staining (1µg/ml) of Human Testis lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Western Blot: Dynactin Subunit 1/DCTN1 Antibody [ABIN249667] - Analysis of DCTN1 in Human Testis lysate (RIPA buffer, 35ug total protein per lane) using this antibody at 1ug/ml. Primary incubated for 1 hour. Detected using chemiluminescence. 0.1 mg Log in to see 5 to 7 Days
Dog Mouse Un-conjugated BI, IF, WB Western blot analysis of p150 [Glued] on a rat cerebrum lysate (left). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti- p150 [Glued] antibody. Immunofluorescent staining of SK-N-SH cells (Human neuroblastoma, ATCC HTB-11) (right). Cells were seeded in collagen coated 384-well imaging microplates at ~ 8,000 cells per well. After overnight incubation, cells were stained using the Triton-X 100 fix/perm protocol with the mouse anti- p150 [Glued] antibody and counter-stained with Hoechst 33342 (pseudo-colored blue). The second step reagent used was Alexa Fluor® 488 goat anti-mouse Ig (pseudo-colored green) (Invitrogen). The images were captured on a BD Pathway™ 855 or 435 Bioimager system using a 20x objective and merged using BD Attovision™ software. This antibody also stained SH-SY5Y (Human neuroblastoma, ATCC CRL-2266) and C6 (Rat glioma, ATCC CCL-107) cells using both the Triton-X 100 and methanol fix/perm protocols. 50 μg Log in to see 5 to 6 Days
Chicken Mouse Un-conjugated IF, IHC (zinc), IP, WB Western blot analysis of p150 [Glued] on a human endothelial cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- p150 [Glued] antibody. Immunoflourescent staining of human endothelial cells. 50 μg Log in to see 5 to 6 Days
Human Mouse Un-conjugated IP, WB DCTN1 (N-terminus) antibody at 1/2000 dilution +HMEPC whole cell lysate 40ug/Lane, Predicted band size: 142kDa, Observed band size: 150kDa 100 μL Log in to see 8 to 9 Days
Human Rabbit Un-conjugated WB WB Suggested Anti-Dctn1 Antibody  Positive Control: Lane 1:841 µg rat brain extract Primary Antibody Dilution: 1:000Secondary Antibody: IRDye 800 CW goat anti-rabbit from Li-COR BioscienceSecondry  Antibody Dilution: 1:00,000Submitted by: Dr. Yuzhi Chen, University of Arkansas for Medical Science WB Suggested Anti-Dctn1 AntibodyTitration: 1.0 µg/mL  Positive Control: Rat Thymus 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: JurKat 5% SDS PAGE antibody diluted at 1:3000 ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa, using DCTN1, antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with  (Red) at 1:2000. 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, WB WB on rat brain lysate using Rabbit antibody to internal part of DCTN1 (DAP-150, DP-150, p150-glued, p135, Dynactin subunit 1): whole serum (ABIN350279) at 1 : 500 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the detected band. 100 μL Log in to see 7 to 8 Days
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using DCTN1 antibody. 100 μL Log in to see 14 Days
Human Goat Un-conjugated IHC (p), ELISA, WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with DCTN1 antibody ABIN337005 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days

DCTN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Dynactin 1 Antibodies

  1. Human Polyclonal Dynactin 1 Primary Antibody for IHC, WB - ABIN350279 : Collin, Nishina, Marshall, Naggert: Human DCTN1: genomic structure and evaluation as a candidate for Alström syndrome. in Genomics 1998 (PubMed)
    Show all 6 references for ABIN350279

  2. Chicken Monoclonal Dynactin 1 Primary Antibody for IF, IHC (zinc) - ABIN967995 : Askham, Vaughan, Goodson, Morrison: Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. in Molecular biology of the cell 2002 (PubMed)
    Show all 5 references for ABIN967995

  3. Human Polyclonal Dynactin 1 Primary Antibody for IF, IHC (p) - ABIN374269 : Williams, Beronja, Pasolli, Fuchs: Asymmetric cell divisions promote Notch-dependent epidermal differentiation. in Nature 2011 (PubMed)
    Show all 4 references for ABIN374269

  4. Human Polyclonal Dynactin 1 Primary Antibody for IHC (p), IHC - ABIN249667 : Bupha-Intr, Haizlip, Janssen: Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro. in American journal of physiology. Heart and circulatory physiology 2009 (PubMed)
    Show all 2 references for ABIN249667

  5. Dog (Canine) Monoclonal Dynactin 1 Primary Antibody for BI, IF - ABIN968918 : Holzbaur, Hammarback, Paschal, Kravit, Pfister, Vallee: Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued. in Nature 1991 (PubMed)
    Show all 2 references for ABIN968918

More Antibodies against Dynactin 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Dynactin 1 (DCTN1) interaction partners

  1. Arfaptin (show ARFIP1 Antibodies) physically associates with Glued and other dynactin complex components in the nervous system of both flies and mice and colocalizes with Glued at the Golgi in motor neurons.

  2. It uncovered an important requirement for Lis1 (show PAFAH1B1 Antibodies) in promoting the recruitment of dynein and its accessory complex dynactin to RNA localization complexes.

  3. multiple independent disruptions of Dynactin function cause a relocation of the photoreceptor nucleus toward the brain

  4. dynein-dynactin, abnormal spindle protein (Asp (show ASIP Antibodies)), and KLP10A (show KIF24 Antibodies) have roles in Drosophila spindle pole organization

  5. We conclude that Lis1 (show PAFAH1B1 Antibodies)/dynactin act together to regulate multiple, independent functions in mitotic cells, including spindle formation and cell cycle checkpoint release.

  6. Microtubule binding depends on the N-terminal domain of p150[glued].

  7. Mutants in the Lis1 (show PAFAH1B1 Antibodies)/dynactin complex strongly decrease maximum and average spindle velocity, consistent with this motor complex mediating spindle/cortex forces.

  8. Dynein-dynactin plays a role in excluding dendritic Dscam (show DSCAM Antibodies) from axons by retrograde transport.

  9. show that this cell polarity regulator interacts with Glued during central synapse formation.

Human Dynactin 1 (DCTN1) interaction partners

  1. Study found that in peripheral blood mononuclear cells the median expression of KIFC3 (show KIFC3 Antibodies), KIF1B (show KIF1B Antibodies), and KIF5C (show KIF5C Antibodies) was much lower than the expression of dynactin subunits DCTN1 and DCTN3 (show Dctn3 Antibodies), in both sporadic amyotrophic lateral sclerosis and healthy cases

  2. Data suggest that cargo concentration at ERES is regulated by p150(glued) to coordinate protein sorting and transport carrier formation with the subsequent long-range transport towards the Golgi complex along microtubules.

  3. Study shows p150glued located at the centrosome in a cell cycle-dependent manner where it is abundant during G1/S phase, located in the minus-end of microtubules during G2/M phase and at the minus-end of microtubules in the mitotic phase.

  4. We find that LRRK1-mediated phosphorylation of CLIP-170 (show CLIP1 Antibodies) causes the accumulation of p150(Glued) (also known as DCTN1) a subunit of dynactin, at microtubule plus ends, thereby facilitating the migration of EGFR (show EGFR Antibodies)-containing endosomes.

  5. The results describe the mutant dynactin p150Glued mouse model of motor neuron disease and show that genetic background influences phenotype in part through a region of chromosome 17 supporting the presence of genetic modifiers.

  6. Dynactin functions as both a dynamic tether and brake during dynein-driven motility.

  7. HPS6 (show HPS6 Antibodies) interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes

  8. Taken together, topographic and functional interactions between dynactin, importin-beta (show KPNB1 Antibodies) and RanBP2 (show RANBP2 Antibodies) are involved in nuclear translocation of IGF-1R (show IGF1R Antibodies).

  9. DCTN1 mutations linked with neurogeneration on Guam.

  10. The results of this study DCTN1 mutations may contribute to disparate neurodegenerative diagnoses, including familial motor neuron disease, parkinsonism, and frontotemporal atrophy.

Mouse (Murine) Dynactin 1 (DCTN1) interaction partners

  1. a mouse model expressing disease linked-G59S mutant dynactin p150(Glued) develops motor dysfunction >8 months before loss of motor neurons or dopaminergic degeneration is observed.

  2. These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor.

  3. Functional relationships between PIK3C3 (show PIK3C3 Antibodies), dynactin, and AnkB (show ANKH Antibodies) promote axonal transport of organelles and are required for normal axon length.

  4. The direct binding of the dynactin subunit p150(Glued) to JIP1 (show MAPK8IP1 Antibodies) competitively inhibits KHC (show KIF5A Antibodies) activation in vitro and disrupts the transport of APP (show APP Antibodies) in neurons.

  5. These data unveil a previously unrecognized role for the dynein-dynactin motor complex in osteoclast formation and function.

  6. in addition to its ciliogenic roles, Kif3a (show KIF3A Antibodies) recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres.

  7. Overexpression of TBCB (show TBCB Antibodies) leads to the decreased localization of p150 (show ABL1 Antibodies) to the microtubule network that might result in a functional modulation of this protein complex.

  8. Melanoregulin (show MREG Antibodies) interacts with the C-terminal domain of Rab-interacting lysosomal protein (RILP (show RILP Antibodies)) and forms a complex with RILP (show RILP Antibodies) and p150(Glued) (also known as dynactin subunit 1, DCTN1), a component of the dynein-dynactin motor complex.

  9. It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 (show SUN1 Antibodies) and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin complex.

  10. Dctn1 plays an important role in mouse spermiogenesis, and mainly affects the formation of the tail of spermatozoa.

Dynactin 1 (DCTN1) Antigen Profile

Protein Summary

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

Gene names and symbols associated with anti-Dynactin 1 (DCTN1) Antibodies

  • dynactin 1 (DCTN1) antibody
  • Glued (Gl) antibody
  • dynactin 1 (p150, glued homolog, Drosophila) (DCTN1) antibody
  • dynactin 1 (Dctn1) antibody
  • dynactin 1 (dctn1) antibody
  • AL022633 antibody
  • CG9206 antibody
  • Chip150 antibody
  • DAP-150 antibody
  • DCTN1 antibody
  • DKFZp469C1813 antibody
  • Dmel\\CG9206 antibody
  • DP-150 antibody
  • Dynactin-1 antibody
  • DYNA_DROME antibody
  • FCP-D antibody
  • Glu antibody
  • glued antibody
  • P135 antibody
  • p150 antibody
  • p150/glued antibody
  • p150 antibody
  • p150[glued] antibody
  • t1 antibody

Protein level used designations for anti-Dynactin 1 (DCTN1) Antibodies

dynactin 1 (p150, glued homolog, Drosophila) , CG9206-PA , Gl-PA , dynactin , dynactin P150 , glued , p150[glued] , p150glued , dynactin 1 , dynactin subunit 1 , dynactin subunit 1-like , 150 kDa dynein-associated polypeptide , DAP-150 , DP-150 , dynactin 1, retrograde axonal transport , p150-glued , dynactin 1 (p150, glued homolog)

100053938 Equus caballus
39536 Drosophila melanogaster
459332 Pan troglodytes
100174308 Pongo abelii
100017556 Monodelphis domestica
100169742 Pongo abelii
100346609 Oryctolagus cuniculus
100475411 Ailuropoda melanoleuca
1639 Homo sapiens
13191 Mus musculus
29167 Rattus norvegicus
483106 Canis lupus familiaris
100519249 Sus scrofa
511045 Bos taurus
426238 Gallus gallus
379696 Xenopus laevis
Selected quality suppliers for anti-Dynactin 1 (DCTN1) Antibodies
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