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Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Additionally we are shipping Epoxide Hydrolase 1, Microsomal (Xenobiotic) Antibodies (109) and Epoxide Hydrolase 1, Microsomal (Xenobiotic) Proteins (10) and many more products for this protein.
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A function of a putative EH gene in the biosynthesis of a sex attractant in the jewel wasp (show WASL ELISA Kits) Nasonia vitripennis and use of this gene to localize the site of pheromone production, is described.
Results show that HYL1 and SE directly interact with HIGLE to processes primary transcripts of MIRNA genes into mature miRNAs.
SMEK1, as a suppressor, inhibits MAPK (show MAPK1 ELISA Kits) activation to attenuate HYL1 phosphorylation; SMEK1 assembles a functional PP4 (show PPP4C ELISA Kits) to target HYL1 for dephosphorylation
Further analysis revealed that the steady state level of HYL1 protein in plants under osmotic stress is dependent on the SnRK2 kinases. Additionally, our results suggest that the SnRK2 kinases physically associate with the miRNA processing components SE and HYL1 and can phosphorylate these proteins in vitro.
Lariat RNAs localized in nuclear bodies, and partially co-localize with HYL1, and both DCL1 (show CD302 ELISA Kits) and HYL1 were mis (show AMH ELISA Kits)-localized in dbr1 (show DBR1 ELISA Kits)-2... we thus propose that lariat RNAs, as decoys, inhibit miRNA processing, suggesting a hitherto unknown layer of regulation in miRNA biogenesis.
Enzymes of the fatty acid degradation pathway were upregulated in DRB1-mutated plants.
cytoplasmic partitioning of COP1 under light is essential to protect HYL1 against protease X.
Data establishes that RNA binding by HYL1 dsRBD1 is essential for its function.
Data suggest a mechanism of plant miRNA maturation which involves binding of the HEN1 (show HENMT1 ELISA Kits) methyltransferase to the DICER-LIKE 1 ribonuclease DCL1 (show CD302 ELISA Kits)*RNA-binding protein HYL1*miRNA complex.
MicroRNA biogenesis factor DRB1 is a phosphorylation target of mitogen activated protein kinase (show MAPK1 ELISA Kits) MPK3 (show MAPK3 ELISA Kits) in both rice and Arabidopsis
The results suggest that HYL1 ensures the correct selection of pri-miRNA cleavage sites through homodimerization and thus contributes to gene silencing and plant development.
Data, including data from mutant strain of mice, suggest critical role of Ephx1 in regulation of vasodynamics (specifically regulation of cerebral blood flow) and suggest that deregulation of endogenous signaling pathways (such as eicosanoid metabolism) is undesirable gain of function associated with E404D variant of Ephx1.
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (show NFE2L2 ELISA Kits) regulation: cytochrome CYP2A5, GSTM3 (show glutathione S-transferase mu 3 (brain) ELISA Kits), GSTM1 (show GSTM1 ELISA Kits), ENTPD5 (show ENTPD5 ELISA Kits),UDPGDH (show UGDH ELISA Kits), and EPHX1.
Expression of HBSP significantly increased the formation of BPDE-DNA adduct in benzo[alpha]pyrene-treated Huh-7 hepatoma cells, and this enhancement was blocked by knockdown of microsomal epoxide hydrolase
In livers of HRN mice Cyp1a1 (show CYP1A1 ELISA Kits), cytochrome b5 (show CYB5A ELISA Kits) and mEH can effectively activate BaP (show PHB2 ELISA Kits) to DNA binding species, even in the presence of very low amounts of P450 (show POR ELISA Kits) oxidoreductase (show HSD17B6 ELISA Kits).
sEH gene deletion is protective against ischemic stroke by a vascular mechanism linked to reduced hydration of circulating EETs
Report effect of CYP2E1 (show CYP2E1 ELISA Kits) gene deletion in mice on expression of microsomal epoxide hydrolase in response to 4-vinylcyclohexene diepoxide exposure. Suggest ovarian expression of CYP2E1 (show CYP2E1 ELISA Kits)/mEH may be linked.
EPHX1 in oviductal cells may enhance the development of cocultured embryos by protecting them from oxidative stress.
The results suggest that epoxide intermediates mediate methamphetamine drug dependence and that astrocytic reactions of microsomal epoxide hydrolase protein are important in the endogenous modulation in response to methamphetamine drug dependence.
The Tyr113His T/C variant of rs1051740 and very slow phenotype alters EPHX1, miR (show MLXIP ELISA Kits)-26b-5p and miR (show MLXIP ELISA Kits)-1207-5p expression, and contributes towards low blood iron levels and low birthweights.
Structural characterization of human microsomal epoxide hydrolase by combined homology modeling, molecular dynamics simulations, and molecular docking calculations has been reported.
Y113H polymorphism in EPHX1 gene contributed to increased susceptibility to COPD (show ARCN1 ELISA Kits) in the Kazakhstan population.
EPHX1 polymorphisms were not associated with sporadic colorectal neoplasms.
This study demonstrated that two SNPs might play roles in the process of nicotine metabolism and abstinence, rs1051740 being more important; and EPHX SNPs (rs1051740 and rs2234922) are associated with the effectiveness of Nicotine Replacement Therapy .
No association was found between EPHX1 and COPD (show ARCN1 ELISA Kits); however, a minor effect of EPHX1 on COPD (show ARCN1 ELISA Kits) risk was not completely excluded.
CYP1B1 (show CYP1B1 ELISA Kits)/EPHX1 genotyping could help to predict the risk of DNA damage and to optimize doses of coal tar (show RBM8A ELISA Kits) and UVR exposure in psoriatic patients in whom Goeckerman therapy was applied.
Null-GSTT1 (show GSTT1 ELISA Kits) and null-GSTM1 (show GSTM1 ELISA Kits) genotypes and Cytochrome P4502E1 (CYP2E1 (show CYP2E1 ELISA Kits): rs2031920, rs3813867) may support the hematotoxicity of benzene-exposed workers in China, and we can make use of it to select susceptible population
The SCN1A (show SCN1A ELISA Kits) IVS5-91G>A SNP is associated with susceptibility to epilepsy. SNPs in EPHX1 gene are influencing CBZ metabolism and disposition
In conclusion, GSTs (show GSTa2 ELISA Kits), EPHX1, and XPD (show ERCC2 ELISA Kits) are potential genetic factors for arsenic-induced skin cancers. The roles of these genes for arsenic-induced skin carcinogenesis need to be further evaluated.
Studied EPHX1 SNPs to analyze effect on increased expression of EPHX1 gene in Berkshire liver by total of 192 pigs.
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
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