Ets Variant 4 Proteins (ETV4)

Transcriptional activator that binds to the enhancer of the adenovirus E1A gene\; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.. Additionally we are shipping ETV4 Antibodies (75) and ETV4 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ETV4 2118 P43268
Rat ETV4 ETV4 360635  
ETV4 18612  
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Top ETV4 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days

ETV4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Ets Variant 4 (ETV4) Interaction Partners

Human Ets Variant 4 (ETV4) interaction partners

  1. FOS strongly binds to the same MED25 (show MED9 Proteins) site as ETV4 activation domain and JUN (show JUN Proteins) interacts with the other two MED25 (show MED9 Proteins) sites.

  2. Our results indicate that assessing AP1 (show FOSB Proteins) and PEA3 transcription factor status might be a good indicator of OAC status. However, we could not detect any associations with disease stage or patient treatment regime. This suggests that the PEA3-AP1 (show FOSB Proteins) regulatory module more likely contributes more generally to the cancer phenotype. In keeping with this observation, depletion of ETV1 (show ETV1 Proteins) and/or ETV4 causes an OAC cell growth defect

  3. ETV4 overexpression is associated with lung cancer metastasis.

  4. Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETV1 (show ETV1 Proteins), ETV4 and ETV5 (show ETV5 Proteins).

  5. The data provide the molecular details of ETV4-mediated NANOG gene expression.

  6. the prostate cancer-related oncogenic E26 transformation-specific (ETS (show ETS1 Proteins)) transcription factors, ETV1 (show ETV1 Proteins), ETV4, and ETV5 (show ETV5 Proteins), were required for TAZ (show TAZ Proteins) gene transcription in PC3 (show PCSK1 Proteins) prostate cancer cells

  7. NCOA2ETV4 protein would contain the helixloophelix, PAS_9 and PAS_11, CITED domains, the SRC1 (show SRC Proteins) domain of NCOA2 (show NCOA2 Proteins) and the ETS (show ETS1 Proteins) DNAbinding domain of ETV4.

  8. PEA3-subgroup transcription factors are key players of the Met signaling integration involved in regulation of migration and invasiveness of tumor cells.

  9. ACC1 and ACLY (show ACLY Proteins) regulate the levels of ETV4 under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1/ACLY (show ACLY Proteins)-alpha-ketoglutarate-ETV4 axis is a novel means by which metabolic states regulate transcriptional output

  10. ETV4 overexpression is associated with prostate cancer aggressiveness.

Zebrafish Ets Variant 4 (ETV4) interaction partners

  1. etv5a (show ETV5 Proteins) and etv4 have roles in mediating epithelial cell fate during zebrafish kidney development

  2. Pea3 and erm (show ETV5 Proteins) are required for zebrafish pronephrogenesis and can functionally complement each other, and the wt1a gene may be one of their downstream targets.

  3. Overlapping functions of pea3 ETS (show ETS1 Proteins) transcription factors in FGF signaling during zebrafish development are reported.

Mouse (Murine) Ets Variant 4 (ETV4) interaction partners

  1. Our results will help understand the mechanism of ETV4 overexpression in CRC patients and provide a clue to search new therapeutic target to treat the related tumors in clinical practice.

  2. ETS-related transcription factors ETV4 and ETV5 (show ETV5 Proteins) are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.

  3. paracrine signaling via fibroblast growth factor 2 (Fgf2 (show FGF2 Proteins)) and Mapk (show MAPK1 Proteins) between these diverged tumor subclones causes enhanced expression of the Pea3 transcription factor, resulting in metastatic dissemination of the neuroendocrine tumor subclones.

  4. Study hypothesized that PEA3 might play an essential role in the activation of the FAK (show PTK2 Proteins) gene during tumor metastasis.

  5. Study reveals molecular insight into how the Ets (show ETS1 Proteins) family transcription factor Pea3 favors EMT (show ITK Proteins) and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2 (show CCND2 Proteins), a new Pea3 target gene.

  6. oncogenic Etv4 promotes prostate cancer metastasis in response to coactivation of PI3-kinase and Ras signaling pathways in a genetically engineered model of highly penetrant, metastatic prostate cancer

  7. PEA3-null fibroblasts exhibit impaired c-src activation and motility defects.

  8. Smad2 (show SMAD2 Proteins) and PEA3 regulate RGC-32 (show C13orf15 Proteins) transcription which is essential for smooth muscle cell differentiation from neural crest cells.

  9. study provides evidence for a protumorigenic role of PEA3 factors in breast neoplasia, and supports targeting the PEA3 transcription factor family in breast cancer

  10. Induction of Pea3 gene expression by peripheral signals is required to coordinate the central position and terminal arborization of specific sets of spinal motor neurons.

ETV4 Protein Profile

Protein Summary

Transcriptional activator that binds to the enhancer of the adenovirus E1A gene\; the core-binding sequence is 5'GT-3'.

Gene names and symbols associated with Ets Variant 4 Proteins (ETV4)

  • ets variant 4 (ETV4)
  • ets variant gene 4 (E1A enhancer binding protein, E1AF) (ETV4)
  • ets variant 4 (Etv4)
  • ets variant gene 4 (etv4)
  • ets variant gene 4 (E1A enhancer binding protein, E1AF) (Etv4)
  • AW414408 protein
  • E1A-F protein
  • E1AF protein
  • ETV4 protein
  • Pea-3 protein
  • pea3 protein
  • PEAS3 protein

Protein level used designations for Ets Variant 4 Proteins (ETV4)

ets variant 4 , ETS translocation variant gene 4 , ets variant gene 4 (E1A enhancer binding protein, E1AF) , ets domain protein , ETS translocation variant 4 , EWS protein/E1A enhancer binding protein chimera , adenovirus E1A enhancer-binding protein , ets variant gene 4 (E1A enhancer-binding protein, E1AF) , polyomavirus enhancer activator 3 homolog , ETS translocation variant 4-like , polyomavirus enhancer activator-3 , ETS domain-containing transcription factor PEA3 , ETS-domain transcription factor pea3 , etID309954.12 , ETS variant protein 4 , POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4)

281149 Bos taurus
395747 Gallus gallus
454715 Pan troglodytes
100065121 Equus caballus
2118 Homo sapiens
533129 Bos taurus
360635 Rattus norvegicus
403641 Canis lupus familiaris
30700 Danio rerio
18612 Mus musculus
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