Ets Variant 6 Proteins (ETV6)

ETV6 encodes an ETS family transcription factor. Additionally we are shipping ETV6 Antibodies (110) and ETV6 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ETV6 2120 P41212
Rat ETV6 ETV6 312777  
ETV6 14011 P97360
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Top ETV6 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,265.17
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HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
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ETV6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Ets Variant 6 (ETV6) Interaction Partners

Zebrafish Ets Variant 6 (ETV6) interaction partners

  1. Dominant-negative truncated ETV6 with deletions of the ETS (show ETS1 Proteins) domain or the PNT (show ETS2 Proteins) domain interfered with repression by full-length ETV6 and affected expression of early hematopoietic and erythroid markers in embryos.

  2. the transcriptional repressor Tel plays an evolutionarily conserved role in angiogenesis: it is indispensable for the sprouting of human endothelial cells and for normal development of the Danio rerio blood circulatory system

Human Ets Variant 6 (ETV6) interaction partners

  1. Data suggest that, for ETV6 (which harbors only a single DNA contact interface for both specific and nonspecific interactions), intersegmental jumping represents a major molecular event that significantly modifies the thermodynamics and kinetics of DNA target search; site-specific DNA binding by ETV6 involves a kinetic intermediate at the cognate sequence.

  2. Our findings suggest ETV6-RUNX1 (show RUNX1 Proteins) is associated with space-time clustering of childhood leukemia (CL) and are consistent with an infection interacting with that oncogene (show RAB1A Proteins) in early life leading to clinical leukemia.

  3. EGFR (show EGFR Proteins) activation leads to the induction of miR (show MLXIP Proteins)-96 expression and suppression of ETV6, which contributes to prostate cancer progression.

  4. we demonstrate the expression of the ETV6-NTRK3 fusion (show NTRK3 Proteins) oncogene (show RAB1A Proteins) in a small subset of inflammatory myofibroblastic tumors

  5. ETV6-NTRK3 (show NTRK3 Proteins) translocated papillary thyroid carcinomas are locoregionally aggressive and can metastasize distantly.

  6. We report 6 cases of secretory carcinomas of the skin harboring the ETV6-NTRK3 (show NTRK3 Proteins) gene fusion

  7. ETV6-ABL1 (show ABL1 Proteins) fusion occurs in both lymphoid and myeloid leukemias; the genomic profile and clinical behavior resemble BCR (show BCR Proteins)-ABL1 (show ABL1 Proteins)-positive malignancies, including the unfavorable prognosis, particularly of acute leukemias. The poor outcome suggests that treatment with tyrosine kinase (show TXK Proteins) inhibitors should be considered for patients with this fusion.

  8. ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions are identified in Spitz tumours and demonstrated that NTRK3 fusions constitutively activate the mitogen-activated protein kinase, phosphoinositide 3-kinase and phospholipase Cgamma1 pathways in melanocytes.

  9. A subset of ALK-negative inflammatory myofibroblastic tumour (IMT) have rearrangement of ROS1 (show ROS1 Proteins), ETV6 or NTRK3 (show NTRK3 Proteins) as a possible oncogenic mechanism.

  10. loss of ETV6 leads to significant overexpression of CLIC5 (show CLIC5 Proteins), which in turn leads to decreased lysosome-mediated apoptosis. Our data suggest that heightened CLIC5 (show CLIC5 Proteins) activity could promote a permissive environment for oxidative stress-induced (show SQSTM1 Proteins) DNA damage accumulation, and thereby contribute to leukemogenesis.

Mouse (Murine) Ets Variant 6 (ETV6) interaction partners

  1. Together with similar observations made in human PAX5 (show PAX5 Proteins)-ETV6(+) B-ALLs, these data identified PAX5 (show PAX5 Proteins)-ETV6 fusion as a potent oncoprotein that drives B-cell leukemia development.

  2. ETV6 DNA binding inhibition is established by the stability of its inhibitory helix

  3. Studied the combination of Etv6-RUNX1 (show RUNX1 Proteins) and Pax5 (show PAX5 Proteins)(+/-) alleles, they generated a transplantable B220 (show PTPRC Proteins) + CD19 (show CD19 Proteins)+ B-ALL with a significant disease incidence; RNA-seq analysis showed a gene expression pattern consistent with arrest at the pre-B stage.

  4. In murine models of B-cell progenitors, evidence found that ETV6- RUNX1 (show RUNX1 Proteins) alters the expression of cytoskeletal regulatory genes, resulting in a block of the CDC42 (show CDC42 Proteins) signaling pathway, and compromises the chemotactic response to CXCL12 (show CXCL12 Proteins).

  5. ETV6-SAM (show TTN Proteins) domain interface mutations block ETV6-NTRK3 (show NTRK3 Proteins)-induced cellular transformation

  6. the autoinhibition of ETV6 DNA binding by sequences C-terminal to its ETS (show ETS1 Proteins) domain

  7. find that both IRS1 (show IRS1 Proteins) and kinase active IGF1R (show IGF1R Proteins) are required for ETV6-NTRK3 (show NTRK3 Proteins) transformation, that tyrosine phosphorylated IRS1 (show IRS1 Proteins) is present in high molecular weight complexes with EN and IGF1R (show IGF1R Proteins), and that EN colocalizes with IGF1R (show IGF1R Proteins) at the plasma membrane

  8. Cytogenetic study of 33 children with ETV6-RUNX1 (show RUNX1 Proteins) positive acute lymphoblastic leukemia predict long term survival.

  9. TEL binding to IRF-8 (show IRF8 Proteins) for recruitment of HDAC3 (show HDAC3 Proteins) is regulated by gamma-interferon (show IFNG Proteins)

  10. the ability of TEL to repress transcription and suppress growth is regulated by sumoylation and nuclear export

ETV6 Protein Profile

Protein Summary

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

Gene names and symbols associated with Ets Variant 6 Proteins (ETV6)

  • ets variant gene 6 (TEL oncogene) (etv6)
  • ets variant 6 (ETV6)
  • ets variant 6 (etv6)
  • ets variant 6 (LOC100352251)
  • ets variant 6 (Etv6)
  • ets variant gene 6 (TEL oncogene) (Etv6)
  • ets variant gene 6 (TEL oncogene) (ETV6)
  • AW123102 protein
  • AW557856 protein
  • etv-6 protein
  • id:ibd2308 protein
  • Tel protein
  • TEL/ABL protein

Protein level used designations for Ets Variant 6 Proteins (ETV6)

transcription factor ETV6 , ztel , ets variant gene 6 (TEL oncogene) , TEL oncogene , ets variant 6 , ETS translocation variant 6 , ETS-related protein Tel1 , TEL1 oncogene , translocation-ets-leukemia , ets domain protein

GENE ID SPECIES
114444 Danio rerio
473366 Pan troglodytes
486685 Canis lupus familiaris
549634 Xenopus (Silurana) tropicalis
100063341 Equus caballus
100352251 Oryctolagus cuniculus
2120 Homo sapiens
312777 Rattus norvegicus
504512 Bos taurus
14011 Mus musculus
395750 Gallus gallus
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