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ETV6 encodes an ETS family transcription factor. Additionally we are shipping ETV6 Antibodies (111) and ETV6 Kits (4) and many more products for this protein.
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Dominant-negative truncated ETV6 with deletions of the ETS (show ETS1 Proteins) domain or the PNT (show ETS2 Proteins) domain interfered with repression by full-length ETV6 and affected expression of early hematopoietic and erythroid markers in embryos.
the transcriptional repressor Tel plays an evolutionarily conserved role in angiogenesis: it is indispensable for the sprouting of human endothelial cells and for normal development of the Danio rerio blood circulatory system
Report ETV6-rearranged low-grade sinonasal adenocarcinomas.
will also provide an overview of common clinical features as well as recommendations for patient screening and follow-up and will debate whether additional clinical features should be included with the germline ETV6 syndrome[review]
The clinical significance of ETV6-RUNX1 (show RUNX1 Proteins).
Deliver the necessary promotional drive for the progression of ETV6-RUNX1 (show RUNX1 Proteins)+ pre-leukaemic cells.
Data suggest that, for ETV6 (which harbors only a single DNA contact interface for both specific and nonspecific interactions), intersegmental jumping represents a major molecular event that significantly modifies the thermodynamics and kinetics of DNA target search; site-specific DNA binding by ETV6 involves a kinetic intermediate at the cognate sequence.
Our findings suggest ETV6-RUNX1 (show RUNX1 Proteins) is associated with space-time clustering of childhood leukemia (CL) and are consistent with an infection interacting with that oncogene (show RAB1A Proteins) in early life leading to clinical leukemia.
EGFR (show EGFR Proteins) activation leads to the induction of miR (show MLXIP Proteins)-96 expression and suppression of ETV6, which contributes to prostate cancer progression.
we demonstrate the expression of the ETV6-NTRK3 fusion (show NTRK3 Proteins) oncogene (show RAB1A Proteins) in a small subset of inflammatory myofibroblastic tumors
ETV6-NTRK3 (show NTRK3 Proteins) translocated papillary thyroid carcinomas are locoregionally aggressive and can metastasize distantly.
We report 6 cases of secretory carcinomas of the skin harboring the ETV6-NTRK3 (show NTRK3 Proteins) gene fusion
Together with similar observations made in human PAX5 (show PAX5 Proteins)-ETV6(+) B-ALLs, these data identified PAX5 (show PAX5 Proteins)-ETV6 fusion as a potent oncoprotein that drives B-cell leukemia development.
ETV6 DNA binding inhibition is established by the stability of its inhibitory helix
Studied the combination of Etv6-RUNX1 (show RUNX1 Proteins) and Pax5 (show PAX5 Proteins)(+/-) alleles, they generated a transplantable B220 (show PTPRC Proteins) + CD19 (show CD19 Proteins)+ B-ALL with a significant disease incidence; RNA-seq analysis showed a gene expression pattern consistent with arrest at the pre-B stage.
In murine models of B-cell progenitors, evidence found that ETV6- RUNX1 (show RUNX1 Proteins) alters the expression of cytoskeletal regulatory genes, resulting in a block of the CDC42 (show CDC42 Proteins) signaling pathway, and compromises the chemotactic response to CXCL12 (show CXCL12 Proteins).
ETV6-SAM (show TTN Proteins) domain interface mutations block ETV6-NTRK3 (show NTRK3 Proteins)-induced cellular transformation
the autoinhibition of ETV6 DNA binding by sequences C-terminal to its ETS (show ETS1 Proteins) domain
find that both IRS1 (show IRS1 Proteins) and kinase active IGF1R (show IGF1R Proteins) are required for ETV6-NTRK3 (show NTRK3 Proteins) transformation, that tyrosine phosphorylated IRS1 (show IRS1 Proteins) is present in high molecular weight complexes with EN and IGF1R (show IGF1R Proteins), and that EN colocalizes with IGF1R (show IGF1R Proteins) at the plasma membrane
Cytogenetic study of 33 children with ETV6-RUNX1 (show RUNX1 Proteins) positive acute lymphoblastic leukemia predict long term survival.
TEL binding to IRF-8 (show IRF8 Proteins) for recruitment of HDAC3 (show HDAC3 Proteins) is regulated by gamma-interferon (show IFNG Proteins)
the ability of TEL to repress transcription and suppress growth is regulated by sumoylation and nuclear export
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
transcription factor ETV6
, ets variant gene 6 (TEL oncogene)
, TEL oncogene
, ets variant 6
, ETS translocation variant 6
, ETS-related protein Tel1
, TEL1 oncogene
, ets domain protein