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Ewing Sarcoma Breakpoint Region 1 Proteins (EWSR1)

EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Additionally we are shipping EWSR1 Antibodies (144) and EWSR1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EWSR1 14030 Q61545
EWSR1 2130 Q01844
Rat EWSR1 EWSR1 289752  
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Top EWSR1 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

EWSR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

Top referenced EWSR1 Proteins

  1. Human EWSR1 Protein expressed in Human - ABIN2720598 : Altmeyer, Neelsen, Teloni, Pozdnyakova, Pellegrino, Grøfte, Rask, Streicher, Jungmichel, Nielsen, Lukas: Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose). in Nature communications 2015 (PubMed)

More Proteins for Ewing Sarcoma Breakpoint Region 1 (EWSR1) Interaction Partners

Mouse (Murine) Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. glycosylation of EWS protein

  2. EWSR1 is involved in the post-transcriptional regulation of Uvrag (show UVRAG Proteins) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.

  3. EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (show BMP2 Proteins) and BMP4 (show BMP4 Proteins) expression.

  4. EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha protein stability

  5. both Etv1 (show ETV1 Proteins) and Ewsr1 were necessary for Fgf10 (show FGF10 Proteins) expression and elongation of the limb bud.

  6. EWS is involved in post-transcriptional regulation of Col4a1 (show COL4A1 Proteins) and CTGF (show CTGF Proteins) via a Drosha (show DROSHA Proteins)-miRNA-dependent pathway.

  7. These results demonstrate that EWS is essential for early brown fat lineage determination.

  8. Forced expression of EWS/ATF1 (show AFT1 Proteins) resulted in the development of EWS/ATF1 (show AFT1 Proteins)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (show AFT1 Proteins)-driven transformation.

  9. these findings suggest that EWS mediates generation of mature let-7g from pre-let-7g.

  10. EWS is likely to play a significant role in maintaining the functional capacity of stem cells.

Zebrafish Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. Mutation of the EWS gene modulates Sox9 (show SOX9 Proteins) gene expression essential for chondrocyte differentiation.

  2. Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development

  3. Interaction between EWSR1/FLI1 (show FLI1 Proteins) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.

Human Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. LRWD1 (show LRWD1 Proteins) is a novel regulator of EWS-FLI1 (show FLI1 Proteins) driven cell proliferation in Ewing sarcoma cells. EWS-FLI1 (show FLI1 Proteins) regulates LRWD1 (show LRWD1 Proteins) expression and LRWD1 (show LRWD1 Proteins) may contribute to EWS-FLI1 (show FLI1 Proteins) mediated transcriptional repression.

  2. Ewing sarcoma may be susceptible to treatment with epigenetic inhibitors blocking BRD3 (show BRD3 Proteins)/4 activity and the associated pathognomonic EWS-FLT1 (show FLT1 Proteins) transcriptional program.

  3. prevalence of the FUS (show FUS Proteins)-ERG (show ERG Proteins) gene fusion in a large cohort of pathologically and molecularly well characterized small blue round cell tumors, lacking other known gene rearrangements

  4. FUS (show FUS Proteins) and EWS target genes involved in pathways at the RNA regulatory level

  5. Identify SP1 (show PSG1 Proteins) and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling as modulators of EWS/FLI1 (show FLI1 Proteins) gene expression in tumor cell lines.

  6. Case Reports: 2 girls with primary renal myoepithelial carcinomas with a novel EWSR1-KLF15 fusion.

  7. 3'-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer.

  8. study investigated EWSR1 status in ovarian hemangiomas; all cases were negative for EWSR1 rearrangement; 2 cases demonstrated additional intact copies of EWSR1 indicating aneusomy 22 or structural abnormality of chromosome 22 resulting in apparent duplication of the EWSR1 gene region

  9. The paper investigates the presence of EWS/FLI-1 (show FLI1 Proteins) fusion in clinically diagnosed sarcoma belonging to different non-Ewing connective tissue tumors.

  10. Results show that RNA-binding protein EWS binds and regulates CCDC6 (show CCDC6 Proteins) expression at RNA and protein levels.

EWSR1 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Gene names and symbols associated with EWSR1

  • Ewing sarcoma breakpoint region 1 (EWSR1)
  • Ewing sarcoma breakpoint region 1 (ewsr1)
  • Ewing sarcoma breakpoint region 1 (Ewsr1)
  • Ewing sarcoma breakpoint region 1a (ewsr1a)
  • EWS RNA-binding protein 1 (EWSR1)
  • EWS RNA-binding protein 1 (Ewsr1)
  • AU018891 protein
  • bK984G1.4 protein
  • DKFZp459K1116 protein
  • Ews protein
  • Ewsh protein
  • EWSR1 protein
  • fc04c01 protein
  • wu:fc04c01 protein

Protein level used designations for EWSR1

RNA-binding protein EWS , Ewing sarcoma RNA-binding protein , Ewing sarcoma breakpoint region 1 , Ewing sarcoma homolog , Ewings sarcoma EWS-Fli1 (type 1) oncogene

748264 Pan troglodytes
100034010 Equus caballus
100018014 Monodelphis domestica
100173925 Pongo abelii
100550662 Meleagris gallopavo
100557388 Anolis carolinensis
100595788 Nomascus leucogenys
417022 Gallus gallus
609786 Canis lupus familiaris
534073 Bos taurus
14030 Mus musculus
100156911 Sus scrofa
323597 Danio rerio
2130 Homo sapiens
289752 Rattus norvegicus
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