Ewing Sarcoma Breakpoint Region 1 Proteins (EWSR1)

EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Additionally we are shipping EWSR1 Antibodies (152) and EWSR1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EWSR1 14030 Q61545
EWSR1 2130 Q01844
Rat EWSR1 EWSR1 289752  
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Top EWSR1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

EWSR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

Top referenced EWSR1 Proteins

  1. Human EWSR1 Protein expressed in HEK-293 Cells - ABIN2720598 : Altmeyer, Neelsen, Teloni, Pozdnyakova, Pellegrino, Grøfte, Rask, Streicher, Jungmichel, Nielsen, Lukas: Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose). in Nature communications 2015 (PubMed)

More Proteins for Ewing Sarcoma Breakpoint Region 1 (EWSR1) Interaction Partners

Mouse (Murine) Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. EWS is normally O-GlcNAc glycosylated in the brain.

  2. glycosylation of EWS protein

  3. EWSR1 is involved in the post-transcriptional regulation of Uvrag (show UVRAG Proteins) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.

  4. EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (show BMP2 Proteins) and BMP4 (show BMP4 Proteins) expression.

  5. EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha protein stability

  6. both Etv1 (show ETV1 Proteins) and Ewsr1 were necessary for Fgf10 (show FGF10 Proteins) expression and elongation of the limb bud.

  7. EWS is involved in post-transcriptional regulation of Col4a1 (show COL4A1 Proteins) and CTGF (show CTGF Proteins) via a Drosha (show DROSHA Proteins)-miRNA-dependent pathway.

  8. These results demonstrate that EWS is essential for early brown fat lineage determination.

  9. Forced expression of EWS/ATF1 (show AFT1 Proteins) resulted in the development of EWS/ATF1 (show AFT1 Proteins)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (show AFT1 Proteins)-driven transformation.

  10. these findings suggest that EWS mediates generation of mature let-7g from pre-let-7g.

Zebrafish Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. Mutation of the EWS gene modulates Sox9 (show SOX9 Proteins) gene expression essential for chondrocyte differentiation.

  2. Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development

  3. Interaction between EWSR1/FLI1 (show FLI1 Proteins) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.

Human Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 (show AFT1 Proteins) gene fusion.

  2. Results expand the spectrum of tumor types harboring EWSR1/FUS (show FUS Proteins)-ATF1 (show AFT1 Proteins) gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.

  3. papillary thyroid carcinomas with EWSR1 rearrangement disclosed a lower percentage of nuclei with EWSR1 polysomy than those without EWSR1 rearrangement

  4. The net result of combined lurbinectedin and irinotecan treatment was a complete reversal of EWS-FLI1 (show FLI1 Proteins) activity and elimination of established tumors in 30% to 70% of mice after only 11 days of therapy. Our results illustrate the preclinical safety and efficacy of a disease-specific therapy targeting the central oncogenic driver in Ewing sarcoma.

  5. Aggregation of FET proteins FUS (show FUS Proteins), EWSR1, and TAF15 (show TAF15 Proteins) mediate a pathological change in amyotrophic lateral sclerosis. (Review)

  6. A subgroup of MAML2 fusion-negative mucoepidermoid carcinomas are actually clear cell carcinoma of the salivary gland with EWSR1 translocation.

  7. Study found consistent DNA hypomethylation at enhancers regulated by the disease-defining EWS-FLI1 (show FLI1 Proteins) fusion protein, thus establishing epigenomic enhancer reprogramming as a ubiquitous and characteristic feature of Ewing sarcoma.

  8. Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1-AFT1/CREB1 (show CREB1 Proteins)/CREM (show CREM Proteins) fusions.

  9. We conclude that in the context of 22q11-12 regional alterations present in SMARCB1 (show SMARCB1 Proteins)-deleted tumors, simultaneous EWSR1 involvement may be misinterpreted as equivalent to EWSR1 rearrangement. A detailed clinicopathologic correlation and supplementing the EWSR1 FISH assay with complementary methodology is mandatory for correct diagnosis

  10. While our study confirmed that fluorescence in-situ hybridization is a sensitive and specific tool in the diagnosis of EWSR1-associated tumours, atypical fluorescence in-situ hybridization signals and classical rearrangement in entities other than EWSR1-associated tumours can occur

EWSR1 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Gene names and symbols associated with EWSR1

  • Ewing sarcoma breakpoint region 1 (EWSR1)
  • Ewing sarcoma breakpoint region 1 (ewsr1)
  • Ewing sarcoma breakpoint region 1 (Ewsr1)
  • Ewing sarcoma breakpoint region 1a (ewsr1a)
  • EWS RNA-binding protein 1 (EWSR1)
  • EWS RNA-binding protein 1 (Ewsr1)
  • AU018891 protein
  • bK984G1.4 protein
  • DKFZp459K1116 protein
  • Ews protein
  • Ewsh protein
  • EWSR1 protein
  • fc04c01 protein
  • wu:fc04c01 protein

Protein level used designations for EWSR1

RNA-binding protein EWS , Ewing sarcoma RNA-binding protein , Ewing sarcoma breakpoint region 1 , Ewing sarcoma homolog , Ewings sarcoma EWS-Fli1 (type 1) oncogene

748264 Pan troglodytes
100034010 Equus caballus
100018014 Monodelphis domestica
100173925 Pongo abelii
100550662 Meleagris gallopavo
100557388 Anolis carolinensis
100595788 Nomascus leucogenys
417022 Gallus gallus
609786 Canis lupus familiaris
534073 Bos taurus
14030 Mus musculus
100156911 Sus scrofa
323597 Danio rerio
2130 Homo sapiens
289752 Rattus norvegicus
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