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EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Additionally we are shipping EWSR1 Antibodies (149) and EWSR1 Kits (3) and many more products for this protein.
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Human EWSR1 Protein expressed in Human - ABIN2720598
Altmeyer, Neelsen, Teloni, Pozdnyakova, Pellegrino, Grøfte, Rask, Streicher, Jungmichel, Nielsen, Lukas: Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose). in Nature communications 2015
EWS is normally O-GlcNAc glycosylated in the brain.
glycosylation of EWS protein
EWSR1 is involved in the post-transcriptional regulation of Uvrag (show UVRAG Proteins) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (show BMP2 Proteins) and BMP4 (show BMP4 Proteins) expression.
EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha protein stability
both Etv1 (show ETV1 Proteins) and Ewsr1 were necessary for Fgf10 (show FGF10 Proteins) expression and elongation of the limb bud.
EWS is involved in post-transcriptional regulation of Col4a1 (show COL4A1 Proteins) and CTGF (show CTGF Proteins) via a Drosha (show DROSHA Proteins)-miRNA-dependent pathway.
These results demonstrate that EWS is essential for early brown fat lineage determination.
Forced expression of EWS/ATF1 (show AFT1 Proteins) resulted in the development of EWS/ATF1 (show AFT1 Proteins)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (show AFT1 Proteins)-driven transformation.
these findings suggest that EWS mediates generation of mature let-7g from pre-let-7g.
Mutation of the EWS gene modulates Sox9 (show SOX9 Proteins) gene expression essential for chondrocyte differentiation.
Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
Interaction between EWSR1/FLI1 (show FLI1 Proteins) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
EWSR1-related rearrangement was detected extraskeletal myxoid chondrosarcoma
a novel EWSR1/ETS (show ETS1 Proteins) chimeric gene, was identified in a patient diagnosed with refractory AML (show RUNX1 Proteins), suggesting a potential role of leukemogenesis in rare cases of AML (show RUNX1 Proteins). This fusion gene is very likely to exhibit oncogenic potential by interfering with the p53 (show TP53 Proteins)/p21 (show CDKN1A Proteins)-dependent pathway.
LRWD1 (show LRWD1 Proteins) is a novel regulator of EWS-FLI1 (show FLI1 Proteins) driven cell proliferation in Ewing sarcoma cells. EWS-FLI1 (show FLI1 Proteins) regulates LRWD1 (show LRWD1 Proteins) expression and LRWD1 (show LRWD1 Proteins) may contribute to EWS-FLI1 (show FLI1 Proteins) mediated transcriptional repression.
Ewing sarcoma may be susceptible to treatment with epigenetic inhibitors blocking BRD3 (show BRD3 Proteins)/4 activity and the associated pathognomonic EWS-FLT1 (show FLT1 Proteins) transcriptional program.
prevalence of the FUS (show FUS Proteins)-ERG (show ERG Proteins) gene fusion in a large cohort of pathologically and molecularly well characterized small blue round cell tumors, lacking other known gene rearrangements
FUS (show FUS Proteins) and EWS target genes involved in pathways at the RNA regulatory level
Identify SP1 (show PSG1 Proteins) and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling as modulators of EWS/FLI1 (show FLI1 Proteins) gene expression in tumor cell lines.
Case Reports: 2 girls with primary renal myoepithelial carcinomas with a novel EWSR1-KLF15 fusion.
3'-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer.
study investigated EWSR1 status in ovarian hemangiomas; all cases were negative for EWSR1 rearrangement; 2 cases demonstrated additional intact copies of EWSR1 indicating aneusomy 22 or structural abnormality of chromosome 22 resulting in apparent duplication of the EWSR1 gene region
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
RNA-binding protein EWS
, Ewing sarcoma RNA-binding protein
, Ewing sarcoma breakpoint region 1
, Ewing sarcoma homolog
, Ewings sarcoma EWS-Fli1 (type 1) oncogene