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The protein encoded by XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Additionally we are shipping Exportin 1, CRM1 Homolog (Yeast) Kits (8) and and many more products for this protein.
Showing 10 out of 66 products:
Chicken Monoclonal XPO1 Primary Antibody for IF, WB - ABIN968674
Boer, Bonten-Surtel, Grosveld: Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis. in Molecular and cellular biology 1998
Show all 6 references for ABIN968674
Human Polyclonal XPO1 Primary Antibody for ICC, IF - ABIN256674
von Knethen, Tzieply, Jennewein, Brüne: Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol. in Journal of cell science 2010
Show all 4 references for ABIN256674
Human Polyclonal XPO1 Primary Antibody for FACS, IHC (p) - ABIN390636
Dong, Biswas, Chook: Structural basis for assembly and disassembly of the CRM1 nuclear export complex. in Nature structural & molecular biology 2009
Show all 2 references for ABIN390636
Human Polyclonal XPO1 Primary Antibody for EIA, WB - ABIN453470
Shen, Wang, Zhao, Zou, Sun, Cheng: Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis. in Neurosurgery 2009
Show all 2 references for ABIN453470
Cow (Bovine) Polyclonal XPO1 Primary Antibody for IHC, IHC (p) - ABIN4300538
Bagheri, Badduke, Qiao, Colnaghi, Abramowicz, Alcantara, Dunham, Wen, Wildin, Nowaczyk, Eichmeyer, Lehman, Maranda, Martell, Shan, Lewis, ODriscoll, Gregory-Evans, Rajcan-Separovic: Identifying candidate genes for 2p15p16.1 microdeletion syndrome using clinical, genomic, and functional analysis. in JCI insight 2016
Cow (Bovine) Polyclonal XPO1 Primary Antibody for WB - ABIN2778849
Cheong, Gunaratnam, Hsu: CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. in The Journal of biological chemistry 2008
Nuclear export of TIS11 (show ZFP36 Antibodies) proteins is mediated by CRM1 through diverging nuclear export signals, while their nuclear import mechanism may rely on a highly conserved signal whose activity is negatively regulated by ZnF2 (show ZNF2 Antibodies) folding.
HPO (show GFER Antibodies) promotes the translocation of SD to the cytoplasm in a CRM1-dependent manner
Exportin-1 is a nuclear export receptor for expanded polyQ containing proteins.
Nuclear localization of the ecdysteroid receptor (EcR) is increased in HeLa cells if exportin-1 (CRM1) is knocked down by siRNA against exportin.
Data show that downregulation of YAN involves CRM1-mediated nuclear export, and that MAE is involved in MAPK (show MAPK1 Antibodies) phosphorylationof YAN.
A major function of DNup88 is to anchor DNup214 (show NUP214 Antibodies) and CRM1 on the nuclear envelope and thereby attenuate NES (show NES Antibodies)-mediated nuclear export.
Phosphorylation of Yan favors Crm1 in this competition and counteracts inhibition of nuclear export by Mae
two functional nuclear export signals are in the Sima basic helix-loop-helix (bHLH) domain and promote CRM1-dependent nuclear export
the interplay between CRM-1 and p27Kip1 (show CDKN1B Antibodies) may provide potentially potent biomarkers and functional targets for the development of future cholangiocarcinoma treatments.
Data show that functional Exportin 1 (XPO1/CRM1) inhibition correlates to XPO1 occupancy by selinexor in U2OS cells.
The results indicate that highly selective targeting of Nup98 (show NUP98 Antibodies)-fusion proteins to Hox (show MSH2 Antibodies) cluster regions via prebound Crm1 induces the formation of higher order chromatin structures that causes aberrant Hox (show MSH2 Antibodies) gene regulation.
Together, our study identifies CRM1 as a valid target in ovarian cancer and provides a basis for the development of S109 in ovarian cancer.
this regulation was conserved in HIV-2 and was dependent on the CRM1-dependent nuclear export pathway suggesting a role of the RNA helicase (show DDX46 Antibodies) in interconnecting nuclear export with ribosome recruitment of the viral unspliced mRNA
HIV-1 depends on host-cell-encoded factors to complete its life cycle; data suggest nucleus-located NAF1 (show TNIP1 Antibodies) (HIV Nef-associated factor 1 (show TNIP1 Antibodies)) promotes nuclear export of un-spliced HIV-1 gag mRNA; association between NAF1 (show TNIP1 Antibodies) and CRM1 is required for this function.
The binding of nuclear export signals to CRM1 in both orientations results in a large expansion in nuclear export signal consensus patterns and therefore a corresponding expansion of potential nuclear export signals in the proteome.
Findings indicate that exportin 1 protein (CRM1) is a valid target for the treatment of colorectal cancer.
our results elucidate that RanGAP1 (show RANGAP1 Antibodies) is actively transported between the nuclear and cytoplasmic compartments, and that the cytoplasmic and NPC (show NPC1 Antibodies) localization of RanGAP1 (show RANGAP1 Antibodies) is dependent on CRM1-mediated nuclear export.
Ribosomal biogenesis appears to be a key component through which XPO1 contributes to tumor cell survival.
CRM1 binds to Axin (show AXIN1 Antibodies) in the presence of RanGTP
Data show that administration of a single dose of selinexor bound Exportin 1 (XPO1/CRM1) for minimally 72 hours both in vitro and in vivo.
These results suggest a model wherein HIV-1 Rev-associated nuclear export signals cooperate to regulate the number or quality of CRM1's interactions with viral Rev/RRE ribonucleoprotein complexes in the nucleus.
map the nuclear import and export signals of Dp71d by truncation and point mutant analysis, showing for the first time Dp71d shuttles between nucleus and cytoplasm mediated by conventional nuclear transporters, importin (show KPNA4 Antibodies) (IMP (show BRAP Antibodies)) alpha/beta and the exportin CRM1
AKT3 (show AKT3 Antibodies) controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1.
A CRM1-mediated nuclear export signal is essential for cytoplasmic localization of neurogenin 3 (show NEUROG3 Antibodies) in neurons.
Bioavailable CRM1 inhibitor KPT-251 significantly inhibited renal cell carcinoma (show MOK Antibodies) growth in vivo with the expected on target effects and no obvious toxicity.
CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells
CaMKI (show CAMK1 Antibodies) vies with CRM1/exportin 1 for access to a nuclear export signal, and assembly of a CaMKI (show CAMK1 Antibodies)-14-3-3 zeta (show YWHAZ Antibodies)-CCTalpha (show PCYT1A Antibodies) complex is a key effector mechanism that drives nuclear CCTalpha (show PCYT1A Antibodies) translocation.
Transcription-independent role of Bach1 (show BACH1 Antibodies) in mitosis through a nuclear exporter Crm1-dependent mechanism.
CRM1 protein-mediated regulation of nuclear clusterin (show CLU Antibodies) (nCLU), an ionizing radiation-stimulated, Bax (show BAX Antibodies)-dependent pro-death factor
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
, chromosomal region maintenance 1
, exportin 1
, exportin 1 (CRM1 homolog, yeast)
, exportin 1-like
, CRM1, yeast, homolog
, chromosome region maintenance 1 protein homolog
, exportin 1 (CRM1, yeast, homolog)
, exportin-1 (required for chromosome region maintenance)
, nuclear export factor CRM1
, CRM1/XPO1 protein