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Fat Mass and Obesity-Associated Proteins (FTO)

FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Antibodies (145) and FTO Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FTO 79068 Q9C0B1
FTO 26383 Q8BGW1
FTO 291905 Q2A121
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Top FTO Proteins at

Showing 7 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Escherichia coli (E. coli) Mouse His tag   10 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 2 to 3 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

FTO Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Fat Mass and Obesity-Associated (FTO) Interaction Partners

Human Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Case Report: MC4R p.Met215del coexisting with FTO and MC1R gene variants, causes severe early onset obesity.

  2. The FTO rs9939609 polymorphism was associated with anthropometric parameters and metabolic syndrome in the younger age group (25-44 years) and in individuals having low level of physical activity.

  3. No significant association between FTO gene polymorphisms and coronary artery disease in type 2 diabetic Iranian patients.

  4. Due to lack of replication regarding FTO association with obesity in the Greek adult population, study analyzed 3 SNPs, i.e. rs9939609, rs9930506 and rs3751812 in a cohort of 203 adults, comprising of 95 obese, 58 overweight and 50 control individuals. Analysis has shown a significant association for FTO (rs9930506; A/G) 'G' allele with obesity and a difference by 3.2 BMI units between homozygote AA versus GG.

  5. The data revealed that the FTO rs9939609 SNP exhibited a significant association with obesity in Taiwanese patients.

  6. carriage of the FTO minor allele was not associated with differential change in adiposity after weight loss interventions. These findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor allele can be at least partly counteracted through such interventions.

  7. An SNP in the FTO (rs9939609) gene but not in the MC4R (show MC4R Proteins) (rs17782313) gene was significantly associated with prepregnancy body mass index (BMI) >/=25 kg/m(2) (relative riskFTO = 2.1; 95% confidence interval [CI], 1.4-3.1). SNPs were not statistically associated with excessive gestational weight gain (GWG) or postpartum weight retention (PPWR).

  8. genetic association studies in population in Spain: Data suggest that an SNP in FTO (rs9939609) is associated with insulin (show INS Proteins) resistance (IR) and hyperlipidemia; in the population studied, maternal FTO polymorphism affects in an opposite manner than neonatal FTO the IR and cardiovascular disease markers in term, normo-weight, appropriate-for-gestational-age neonates.

  9. Our findings demonstrate that ENPP1 (show ENPP1 Proteins), TCF7L2 (show TCF7L2 Proteins), and FTO may predispose to T2DM in the mixed-ancestry population.

  10. FTO rs9939609, MC4R (show MC4R Proteins) rs17782313, and PPARgamma (show PPARG Proteins) rs1801282 polymorphisms seem to have little effect on the incidence of metabolic malfunctions and no effect on androgen-related disorders in the examined middle-aged and elderly men.

Mouse (Murine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Fto deficiency affects the gene and miR130/miR378 expression involved in brown adipogenesis and browning of white adipose tissue in mice.

  2. Here we show that FTO expression is increased after ureteral obstruction and renal fibrosis.

  3. Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma (show PPARG Proteins) and PI3K/Akt (show AKT1 Proteins) signaling.

  4. These results reveal that FTO regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4 (show ANGPTL4 Proteins).

  5. FTO-dependent N6-methyladenosine demethylation may be affected by betaine.

  6. FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1 (show ARNTL Proteins)-induced transcription.

  7. FTO expression and N6-methyladenosine levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis.

  8. FTO is present in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments, possibly by interaction with XPO2 (show CSE1L Proteins).

  9. FTO plays an important role in the development of metabolic disorders and is an interesting target for therapeutic agents.

  10. data suggest that IRX3 (show IRX3 Proteins) is a functional long-range target of obesity-associated variants within FTO and represents a novel determinant of body mass and composition

Pig (Porcine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.

  2. In pig, the FTO gene influences back fat depth in the commercial populations.

  3. This study will provide clues for obtaining a better understanding of the porcine FTO gene function.

  4. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.

  5. The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.

Cow (Bovine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. 34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.

  2. association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 Proteins) yield

  3. Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.

FTO Protein Profile

Protein Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Gene names and symbols associated with FTO

  • fat mass and obesity associated (FTO)
  • fat mass and obesity associated (Fto)
  • fat mass and obesity associated (fto)
  • AW743446 protein
  • mKIAA1752 protein
  • RGD1305121 protein

Protein level used designations for FTO

alpha-ketoglutarate-dependent dioxygenase FTO , fat mass and obesity-associated protein , protein fto , protein fatso , fat mass and obesity associated protein , Protein fatso

79068 Homo sapiens
26383 Mus musculus
478125 Canis lupus familiaris
100127165 Sus scrofa
291905 Rattus norvegicus
100060565 Equus caballus
618622 Bos taurus
100125353 Ovis aries
447305 Xenopus laevis
100173222 Pongo abelii
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