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Filamin A, alpha Proteins (FLNA)

The protein encoded by FLNA is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. Additionally we are shipping Filamin A Antibodies (132) and Filamin A Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FLNA 2316 P21333
Rat FLNA FLNA 293860  
Mouse FLNA FLNA 192176 Q8BTM8
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Top Filamin A Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FLNA Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Filamin A, alpha (FLNA) Interaction Partners

Zebrafish Filamin A, alpha (FLNA) interaction partners

  1. Knockdown of filamin A or vimentin (show VIM Proteins) in normal cells profoundly suppresses apical extrusion of the neighbouring transformed cells.

Fruit Fly (Drosophila melanogaster) Filamin A, alpha (FLNA) interaction partners

  1. study identifies Cher as a new target of JNK (show MAPK8 Proteins) signaling that links cytoskeleton dynamics to tumor progression.

  2. Data indicate that during embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells.

  3. Filamin is required for ovarian follicle cell motility during oogenesis.

Human Filamin A, alpha (FLNA) interaction partners

  1. Filamin-A is required to mediate SSTR2 (show SSTR2 Proteins) effects in pancreatic neuroendocrine tumours

  2. The function of different integrins is subjected to differential regulation by FLNa.

  3. FLNA functions as a positive cellular transducer linking actin polymerization to MKL1-SRF activity, counteracting the known repressive complex of MKL1 and monomeric G-actin (show ACTB Proteins).

  4. Missense substitutions in FLNA were identified in four unrelated craniosynostosis patients.

  5. studies suggest that Vpu hijacks the FLNa function in the modulation of tetherin (show BST2 Proteins) to neutralize the antiviral factor tetherin (show BST2 Proteins).

  6. Our interpretation of these contradictions is that truncation and/or mutation of RhoGDI2 (show ARHGDIB Proteins) perturbs its conformation to expose a site that adventitiously binds FLNA and is not a bona-fide interaction.

  7. Extracellular sphingosine-1-phosphate activates NF-kappaB (show NFKB1 Proteins) only in melanoma cells that lack FLNA.

  8. FLNA anchors PC2 (show KRT6B Proteins) to the actin cytoskeleton through complex PC2 (show KRT6B Proteins)-FLNA-actin to reduce degradation and increase stability, and possibly regulate PC2 (show KRT6B Proteins) function in a Ca-dependent manner.

  9. These observations imply that other interactions apart from those mediated by the canonical repeat 24 dimerisation interface contribute to FLNA homodimerization and that mutations affecting this region of the protein can have broad phenotypic effects.

  10. Our results support FLNA as a new downstream effector of mTORC2 (show CRTC2 Proteins) controlling GBM cell motility.

Pig (Porcine) Filamin A, alpha (FLNA) interaction partners

  1. filamin reduces ENaC (show SCNN1A Proteins) channel function through direct interaction on the cell surface

Mouse (Murine) Filamin A, alpha (FLNA) interaction partners

  1. Bones lacking filamin A are protected from estrogen-mediated post-menopausal osteoporosis

  2. findings suggest a model in which filamin A local translation following axon injury controls localized HDAC5 (show HDAC5 Proteins) activity to promote axon regeneration.

  3. Deletion of filamin A in endothelial cells aggravated myocardial infarction-induced left ventricle dysfunction and cardiac failure as a result of defective endothelial response

  4. A new signaling set, phosphatidic acid-S6K1-FLNA-actin, sheds light into the morphogenic pathway of cytoskeletal structures that are crucial for adhesion and cell locomotion during inflammation and metastasis.

  5. Filamin-A is associated with neutrophil uropod retraction.

  6. Analysis of editing in the filamin A encoding mRNA shows very high editing levels outside the nervous system; further shows FLNA editing is mainly achieved by ADAR2 (show ADARB1 Proteins) but that in some cases ADAR1 (show ADAR Proteins) can efficiently compensate for ADAR2 (show ADARB1 Proteins).

  7. Filamin a, b-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeleton.

  8. a major function of FLNa in modulating ion channel abundance and membrane trafficking in neurons, thereby shaping their biophysical properties and function.

  9. FLNA, a large cytoskeletal actin-binding protein (show PFN1 Proteins), physically interacts with HIF-1alpha (show HIF1A Proteins) and promotes tumor growth and angiogenesis.

  10. coordinated interactions between actin (through FlnA) and vesicle trafficking (through Big2-Arf) direct the assembly and disassembly of membrane protein complexes required for neuronal migration and neuroependymal integrity.

Filamin A (FLNA) Protein Profile

Protein Summary

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Filamin A, alpha Proteins (FLNA)

  • filamin A, alpha (actin binding protein 280) (flna)
  • filamin A, alpha (FLNA)
  • filamin B, like (flnbl)
  • filamin A, alpha (flna)
  • cheerio (cher)
  • filamin A, alpha (Flna)
  • filamin, alpha (Flna)
  • ABP-280 protein
  • ABPX protein
  • cb967 protein
  • CG3937 protein
  • Cher protein
  • CSBS protein
  • CVD1 protein
  • Dilp2 protein
  • Dmel\\CG3937 protein
  • F730004A14Rik protein
  • fb98b06 protein
  • Fil protein
  • filamin-1 protein
  • FLN protein
  • FLN-A protein
  • Fln1 protein
  • flna protein
  • FMD protein
  • joy protein
  • MGC147094 protein
  • MNS protein
  • NHBP protein
  • OPD protein
  • OPD1 protein
  • OPD2 protein
  • RGD1560614 protein
  • sko protein
  • wu:fb98b06 protein
  • wu:fd09g03 protein
  • wu:fd18g06 protein
  • wu:fd49a06 protein
  • XLVD protein
  • XMVD protein

Protein level used designations for Filamin A, alpha Proteins (FLNA)

fd09g03 , filamin A, alpha (actin binding protein 280) , filamin B, like , filamin A, alpha , filamin-A , CG3937-PA , CG3937-PB , CG3937-PF , CG3937-PG , CG3937-PH , CG3937-PI , CG3937-PK , CG3937-PL , CG3937-PM , CG3937-PN , Filamin-1 , Filamin-A , cher-PA , cher-PB , cher-PF , cher-PG , cher-PH , cher-PI , cher-PK , cher-PL , cher-PM , cher-PN , filamin , filamin B , filamin isoform B , filamin-240 , shi kong , actin binding protein 280 , alpha-filamin , endothelial actin-binding protein , filamin-1 , non-muscle filamin , Endothelial actin-binding protein 280) , filamin, alpha , 450 kDa protein , FLN-A , GENA 379 , actin-binding protein 280 , dilated pupils 2 , filamin A

GENE ID SPECIES
562529 Danio rerio
699524 Macaca mulatta
569979 Danio rerio
587317 Strongylocentrotus purpuratus
779840 Xenopus (Silurana) tropicalis
100137263 Papio anubis
42066 Drosophila melanogaster
100380643 Salmo salar
2316 Homo sapiens
293860 Rattus norvegicus
481084 Canis lupus familiaris
733585 Sus scrofa
281165 Bos taurus
100328754 Oryctolagus cuniculus
100725162 Cavia porcellus
395261 Gallus gallus
101120390 Ovis aries
192176 Mus musculus
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