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Filamin A Products

(Filamin A, alpha (FLNA))
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009].

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Featured Filamin A Categories

Filamin A Antibodies

High quality antibodies with extensive validation data.

Filamin A ELISA Kits

Reliable ELISA kits for a wide range of species.

Filamin A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Filamin A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7440788
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (11)
Cat. No. ABIN6256196
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), PLA
Validations
  • (8)
  • (5)
Cat. No. ABIN560922
Quantity 100 μg
Datasheet Datasheet

Recommended Filamin A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955914
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381139
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN512498
Quantity 96 tests
Datasheet Datasheet

Recommended Filamin A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354202
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2721188
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7412995
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Filamin A products

Justa-Schuch, Silva-Garcia, Pilla, Engelke, Kilisch, Lenz, Möller, Nakamura, Urlaub, Geiss-Friedlander: "DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk." in: eLife, Vol. 5, (2016) (PubMed).

Zhao, Ma, Hu, Zang, Tian, Zhang: "Filamin A (FLNA) modulates chemosensitivity to docetaxel in triple-negative breast cancer through the MAPK/ERK pathway." in: Tumour biology, Vol. 37, Issue 4, pp. 5107-15, (2016) (PubMed).

Mingione, Verdelli, Ferrero, Vaira, Guarnieri, Scillitani, Vicentini, Balza, Beretta, Terranegra, Vezzoli, Soldati, Corbetta: "Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors." in: Journal of molecular endocrinology, Vol. 58, Issue 2, pp. 91-103, (2016) (PubMed).

Parrini, Mei, Pisanti, Catarzi, Pucatti, Bianchini, Mascalchi, Bertini, Morrone, Cavaliere, Guerrini: "Familial periventricular nodular heterotopia, epilepsy and Melnick-Needles Syndrome caused by a single FLNA mutation with combined gain-of-function and loss-of-function effects." in: Journal of medical genetics, Vol. 52, Issue 6, pp. 405-12, (2015) (PubMed).

Bézie, Picarda, Tesson, Renaudin, Durand, Ménoret, Mérieau, Chiffoleau, Guillonneau, Caron, Anegon: "Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells." in: PLoS ONE, Vol. 10, Issue 3, pp. e0119686, (2015) (PubMed).

Campos, Rodriguez, Machado Leopoldino, Hait, Lopez Bergami, Castro, Sanchez, Maceyka, Spiegel, Alvarez: "Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-?B Activation in Melanoma Cells by Inhibition of Akt Signaling." in: Molecular and cellular biology, (2015) (PubMed).

Henkels, Mallets, Dennis, Gomez-Cambronero: "S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 4, pp. 1299-313, (2015) (PubMed).

Peverelli, Giardino, Treppiedi, Vitali, Cambiaghi, Locatelli, Lasio, Spada, Lania, Mantovani: "Filamin A (FLNA) plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells." in: Endocrinology, Vol. 155, Issue 8, pp. 2932-41, (2014) (PubMed).

Oegema, Hulst, Theuns-Valks, van Unen, Schot, Mancini, Schipper, de Wit, Sibbles, de Coo, Nanninga, Hofstra, Halley, Brooks: "Novel no-stop FLNA mutation causes multi-organ involvement in males." in: American journal of medical genetics. Part A, Vol. 161A, Issue 9, pp. 2376-84, (2013) (PubMed).

Sakane, Alamir Mahmoud Abdallah, Nakano, Honda, Kitamura, Imoto, Matsushita, Sasaki: "Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 18, Issue 9, pp. 810-22, (2013) (PubMed).

Synonyms and alternative names related to Filamin A

filamin A (FLNA), filamin A, alpha (actin binding protein 280) (flna), filamin, alpha (Flna), filamin A (Flna), filamin-A (LOC587317), filamin A (flna), cheerio (cher), filamin-A (LOC100380643), ABP-280, ABPX, CG3937, Cher, CSBS, CVD1, Dilp2, Dmel\\CG3937, F730004A14Rik, fb98b06, Fil, filamin-1, FLN, FLN-A, FLN1, Fln1, FMD, joy, MGC147094, MNS, NHBP, OPD, OPD1, OPD2, RGD1560614, sko, wu:fb98b06, wu:fd09g03, wu:fd49a06, XLVD, XMVD

Protein level used designations for Filamin A

  • actin binding protein 280
  • alpha-filamin
  • endothelial actin-binding protein
  • filamin-1
  • filamin-A
  • non-muscle filamin
  • filamin A, alpha (actin binding protein 280)
  • fd09g03
  • FLN-A
  • GENA 379
  • actin-binding protein 280
  • dilated pupils 2
  • filamin A
  • Endothelial actin-binding protein 280)
  • filamin, alpha
  • filamin A, alpha
  • CG3937-PA
  • CG3937-PB
  • CG3937-PF
  • CG3937-PG
  • CG3937-PH
  • CG3937-PI
  • CG3937-PK
  • CG3937-PL
  • CG3937-PM
  • CG3937-PN
  • Filamin-1
  • Filamin-A
  • cher-PA
  • cher-PB
  • cher-PF
  • cher-PG
  • cher-PH
  • cher-PI
  • cher-PK
  • cher-PL
  • cher-PM
  • cher-PN
  • filamin
  • filamin B
  • filamin isoform B
  • filamin-240
  • shi kong
  • 450 kDa protein
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