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Fukutin (FKTN) ELISA Kits

The protein encoded by FKTN is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. Additionally we are shipping Fukutin Antibodies (59) and Fukutin Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FKTN 2218 O75072
FKTN 246179 Q8R507
Anti-Rat FKTN FKTN 362520  
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More ELISA Kits for Fukutin Interaction Partners

Zebrafish Fukutin (FKTN) interaction partners

  1. Fukutin and FKRP (show FKRP ELISA Kits) have functions that affect ocular development in zebrafish independently of dystroglycan (show DAG1 ELISA Kits).

  2. Muscle pathology in embryos lacking Fukutin or FKRP (show FKRP ELISA Kits) is different from loss of dystroglycan (show DAG1 ELISA Kits); knockdown of Fukutin or FKRP (show FKRP ELISA Kits) leads to a notochord defect and a perturbation of laminin expression before muscle degeneration.

Human Fukutin (FKTN) interaction partners

  1. Mutation in the fukutin gene is associated with Fukuyama congenital muscular dystrophy and microcephaly.

  2. four new non-Japanese patients with FKTN mutations and congenital muscular dystrophy

  3. FKTN mutations are the most common genetic cause of congenital muscular dystrophies with defective alpha-dystroglycan glycosylation in Korea

  4. In Fukuyama congenital muscular dystrophy (FCMD) cases, expression of fukutin looked decreased.

  5. Fukutin is associated with Walker-Warburg syndrome.

  6. Data suggest that fukutin and fukutin-related protein (FKRP (show FKRP ELISA Kits)) may be involved at different steps in O-mannosylglycan synthesis of alpha-dystroglycan, and FKRP (show FKRP ELISA Kits) is most likely involved in the initial step in this synthesis.

  7. Fukutin seems to bind to both the hypoglycosylated and fully glycosylated form of alpha-dystroglycan, and seems bind to the core area rather than the sugar chain of alpha-dystroglycan

  8. Walker-Warburg syndrome carries a homozygous-single nucleotide insertion that produces a frameshift, or 2 mutations, a point mutation that produces an amino acid substitution, & deletion in 3'UTR (show UTS2R ELISA Kits) that affects the polyadenylation signal of fukutin gene.

  9. FCMD mutations are a more common cause of Walker-Warburg syndrome outside of the Middle East.

  10. The homozygous nonsense mutations within the coding region identified in Turkish patients are predicted to cause a total loss of fukutin activity and are likely to produce a more severe phenotype which closely resembles WWS.

Mouse (Murine) Fukutin (FKTN) interaction partners

  1. Fktn deficient mice express moderate to severe muscular dystrophy; glycosylated alpha-dystroglycan has a unique role in muscle regeneration in these mice

  2. Mouse fukutin deletion impairs dystroglycan (show DAG1 ELISA Kits) processing, recapitulates muscular dystrophy and is relevant to modifications near the dystroglycan (show DAG1 ELISA Kits) O-mannose sugar.

  3. disease-causing missense mutations cause abnormal folding and localization of fukutin protein

  4. the highly hydrophobic transmembrane domain of Fukutin-1 was purified; the identity of the peptide and revealed that in hydrophobic solvents mimicking the bilayer, the peptide adopts a well-structured alpha-helix as predicted from the sequence.

  5. Fukuyama-type congenital muscular dystrophy (FCMD) murine ortholog, Fcmd is 90% identical to that of its human counterpart

  6. Merosin (show LAMA2 ELISA Kits)-deficient congenital muscular dystrophy with mental retardation and cerebellar cysts, unlinked to the FCMD locus, in three Tunisian patients

  7. These results support the hypothesis that fukutin is involved in the glycosylation process of alpha-DG and that a defect in this process plays an essential role in the pathogenesis of FCMD.

  8. The basal lamina of the cortical surface in chimeras showed defects at E14, coinciding with the earliest time point at which ectopia were detected

  9. From these findings, we propose that fukutin forms a complex with POMGnT1 (show POMGNT1 ELISA Kits) and may modulate its enzymatic activity.

  10. fukutin plays crucial roles in the myelination of peripheral nerve and formation of neuromuscular junction. suggest that defective glycosylation of alpha-dystroglycan may play a role in the impairment of these processes in the deficiency of fukutin.

Fukutin (FKTN) Antigen Profile

Antigen Summary

The protein encoded by this gene is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with Fukutin (FKTN) ELISA Kits

  • Fukuyama type congenital muscular dystrophy (fukutin) (FCMD) antibody
  • fukutin (FKTN) antibody
  • fukutin (fktn) antibody
  • Fukutin (Bm1_09375) antibody
  • Fukutin (Bm1_09380) antibody
  • Fukutin (Bm1_44655) antibody
  • fukutin (Fktn) antibody
  • fukutin-like (LOC536891) antibody
  • CMD1X antibody
  • D830030O17Rik antibody
  • Fcmd antibody
  • FKTN antibody
  • im:7163166 antibody
  • LGMD2M antibody
  • MDDGA4 antibody
  • MDDGB4 antibody
  • MDDGC4 antibody
  • zgc:162828 antibody

Protein level used designations for Fukutin (FKTN) ELISA Kits

Fukuyama type congenital muscular dystrophy (fukutin) , fukutin , Fukutin , Fukuyama type congenital muscular dystrophy protein , patient fukutin , Fukuyama type congenital muscular dystrophy homolog

712201 Macaca mulatta
427303 Gallus gallus
100006345 Danio rerio
464634 Pan troglodytes
100054199 Equus caballus
495324 Xenopus laevis
6096801 Brugia malayi
6096802 Brugia malayi
6103815 Brugia malayi
100124956 Xenopus (Silurana) tropicalis
2218 Homo sapiens
481652 Canis lupus familiaris
246179 Mus musculus
362520 Rattus norvegicus
100521942 Sus scrofa
536891 Bos taurus
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