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The protein encoded by GATA5 is a transcription factor that contains two GATA-type zinc fingers. Additionally we are shipping GATA5 Antibodies (64) and GATA5 Proteins (6) and many more products for this protein.
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GATA5 is expressed in microvascular endothelial cells and its inactivation in mice leads to vascular endothelial dysfunction and hypertension.
GATA (show QRSL1 ELISA Kits) transcription factors are repressors of hedgehog (show SHH ELISA Kits) signaling, and NKX3.2 (show NKX3-2 ELISA Kits) maintains the ability of sclerotomal cells to express SHH (show SHH ELISA Kits) transcriptional targets in the presence of BMP signals by repressing the induction of Gata4 (show GATA4 ELISA Kits)/5/6
Gata5 deficiency induces airway hyperresponsiveness, at least in part, by blunting apoE (show APOE ELISA Kits) and increasing IL-13 (show IL13 ELISA Kits) expression.
Expression of Gata5 very efficiently promotes cardiomyocyte fate from murine embryonic stem cells.
USF1 transactivates GATA5 expression by binding to the E-box in its promoter
compound Gata4 (show GATA4 ELISA Kits)/Gata5 and Gata5/Gata6 (show GATA6 ELISA Kits) mutants die embryonically or perinatally due to severe congenital heart defects
Results unravel a critical cell-autonomous role for endocardial Gata5 in aortic valve formation and identify GATA5 as a potential gene responsible for congenital heart disease in humans.
These results demonstrate functional redundancy between Gata4 and Gata5 during cardiac development and implicate Gata5 as a candidate modifier gene for congenital heart disease.
data reveal that transcription factor GATA5 is required for differentiation of cardiogenic precursors into endothelial endocardial cells
collaboration between GATA-6 (show GATA6 ELISA Kits) and GATA-4 (show GATA4 ELISA Kits), or GATA-6 (show GATA6 ELISA Kits) and GATA-5 which can substitute for GATA-4 (show GATA4 ELISA Kits), is involved in the perception of differentiation cues by embryonic stem cells in their determination of endoderm lineage
The Correlation between GATA5, WT1 (show WT1 ELISA Kits) and PAX5 (show PAX5 ELISA Kits) methylation and clinical/histological parameters is suggestive of applicability of these markers in non-invasive (epi (show TFPI ELISA Kits))genetic testing in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)).
we identified gene promoter methylation signatures (WT1 (show WT1 ELISA Kits), MSH6 (show MSH6 ELISA Kits), GATA5 and PAX5 (show PAX5 ELISA Kits)) that are strongly correlated to, and can have a predictive value for the clinical outcome of oral squamous cell carcinoma patients
Evidence supporting a genetic basis includes the autosomal dominance of Bicuspid aortic valve inheritance patterns, and the identification of mutations in GATA binding protein 5 transcription factor.
Transcriptomic analysis of human microvascular endothelial cells with GATA5 knockdown reveals that GATA5 affects several genes and pathways critical for endothelial function.
This study firstly links GATA5 mutation to DCM, which provides novel insight into the molecular mechanisms of DCM, suggesting a potential molecular target for the prenatal prophylaxis and allele-specific treatment of DCM.
Promoter hypermethylation is an important mechanism of the transcriptional inactivation of GATA5 in invasive ductal breast carcinoma.
A combination of GATA5 and SFRP2 (show SFRP2 ELISA Kits) methylation could be promising as a marker for the detection and diagnosis of colorectal cancers and adenomas.
A new potentially pathogenic variant in GATA5 contributes to the development of bicuspid aortic valve syndrome.
DSVs in the GATA5 gene promoter may increase the susceptibility to the development of VSD as a risk factor.
Rare sequence variants, p.Gln3Arg and p.Leu233Pro, in GATA5 are associated with human bicuspid aortic valve.
The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.
GATA binding protein 5
, GATA-binding factor 5
, GATA-binding protein 5
, Transcription factor GATA-5 (GATA binding factor-5)
, transcription factor GATA-5
, GATA binding factor-5
, GATA-5 transcription factor