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GTP Cyclohydrolase 1 Proteins (GCH1)

GCH1 encodes a member of the GTP cyclohydrolase family. Additionally we are shipping GTP Cyclohydrolase 1 Antibodies (92) and GTP Cyclohydrolase 1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GCH1 2643 P30793
GCH1 14528 Q05915
GCH1 29244 P22288
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Top GTP Cyclohydrolase 1 Proteins at

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast REACT_Velvet bean His tag   1 mg Log in to see 56 to 66 Days
Yeast Oncorhynchus mykiss His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
Yeast Euglena gracilis His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days

GCH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus) ,

Top referenced GTP Cyclohydrolase 1 Proteins

  1. Human GCH1 Protein expressed in Wheat germ - ABIN1354910 : Widder, Chen, Li, Dikalov, Thöny, Hatakeyama, Harrison: Regulation of tetrahydrobiopterin biosynthesis by shear stress. in Circulation research 2007 (PubMed)

More Proteins for GTP Cyclohydrolase 1 (GCH1) Interaction Partners

Human GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. This study found that rs11158026 (GCH1) is associated with Parkinson disease in Iran population.

  2. No association between the GCH1 pain-protective haplotype and cervical dilation was found, but a previously demonstrated association with increased use of second-line analgesia was confirmed.

  3. GTPCH/Ang-1 (show ANGPT1 Proteins) interaction in stromal fibroblasts and activation of Tie2 (show TEK Proteins) on breast tumor cells could play an important role in supporting breast cancer growth. GTPCH may be an important mechanism of paracrine tumor growth and hence a target for therapy in breast cancer.

  4. suggest that the GCH1 and MIR4697 but not SIPA1L2 and VPS13C are genetic loci influencing risk of Parkinson's disease in Taiwan

  5. The risk of orofacial clefts is associated with variants of the GCH1 gene related to BH4 metabolism.

  6. Exonic deletion in the GCH1 gene only accounted for the etiology in a small percentage of patients with sporadic dopa-responsive dystonia in our Han Chinese cohort.

  7. identified a novel missense variant, c.5A > G, p.(Glu2Gly), within the GCH1 gene in affected family members displaying a range of phenotypes; variant is pathogenic in studied family and may underlie Parkinson's disease and Dopa-responsive dystonia

  8. No association was seen between the pain protective GCH-1 haplotype and the development of hypersensitivity following injury. An increase in baseline pain thresholds was seen between visits in protective haplotype carriers who sensitized to injury.

  9. Postherniotomy pain and related activity impairment was associated with functional variations in GCH1 (and COMT (show COMT Proteins)).

  10. This is the first study to report changes in the expression of GTP Cyclohydrolase I of this gene in schizophrenia.

Mouse (Murine) GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. Cardiomyocyte-specific overexpression of GTP cyclohydrolase I (mGCH) increases BH4 several-fold in the heart.

  2. gene expression analysis after iNOS (show NOS2 Proteins) induction identified 78 genes that were altered between wild-type and Gch1(fl/fl (show FLT3LG Proteins))Tie2cre macrophages

  3. Data indicate that global deficiency in GTP cyclohydrolase I (Gch1) is embryonically lethal between E11.5 and E13.5.

  4. There is a cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

  5. Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 (show FCGR1A Proteins) in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.

  6. The GTPCH I/Tetreahydrobiopterin pathway is critical to preserve endothelial progenitor cells quantity, function, and regenerative capacity during wound healing in type 1 diabetic mice.

  7. maintenance of endothelial GTPCH I expression and the resulting improvement in BH4 biosynthesis ameliorate diabetic nephropathy

  8. The involvement of the GCH1 gene in pain models using the hyperphenylalaninemia 1 (hph-1 (show EGLN2 Proteins)) mouse, is reported.

  9. GTPCH1 non-covalently interacts with polyubiquitin via an ubiquitin-binding domain.

  10. The data suggest that GCH1 inhibition reduces tumor growth by (i) direct killing of tumor cells, (ii) by inhibiting angiogenesis, and (iii) by enhancing the antitumoral immune response

GTP Cyclohydrolase 1 (GCH1) Protein Profile

Protein Summary

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme.

Gene names and symbols associated with GTP Cyclohydrolase 1 Proteins (GCH1)

  • GTP cyclohydrolase 1 (GCH1)
  • GTP cyclohydrolase 1 (gch1)
  • GTP cyclohydrolase 1 (Celly_2302)
  • GTP cyclohydrolase 1 (Celly_3166)
  • GTP cyclohydrolase 1 (Weevi_1190)
  • GTP cyclohydrolase 1 (Halhy_0838)
  • GTP cyclohydrolase 1 (Sinme_1220)
  • GTP cyclohydrolase 1 (Sphch_1077)
  • GTP cyclohydrolase 1 (Gch1)
  • DYT5 protein
  • DYT5a protein
  • DYT14 protein
  • Gch protein
  • gch1a protein
  • GTP-CH protein
  • GTP-CH-1 protein
  • GTPCH protein
  • GTPCH1 protein
  • HPABH4B protein
  • MGC89622 protein
  • wu:fc16b10 protein
  • zgc:195269 protein

Protein level used designations for GTP Cyclohydrolase 1 Proteins (GCH1)

GTP cyclohydrolase 1 (dopa-responsive dystonia) , GTP cyclohydrolase 1 , GTP cyclohydrolase I , GTP-CH-I , dystonia 14 , guanosine 5'-triphosphate cyclohydrolase I , GTP cyclohydrolase I (form A; N-terminus)

286815 Bos taurus
609393 Canis lupus familiaris
695675 Macaca mulatta
743728 Pan troglodytes
448485 Xenopus (Silurana) tropicalis
10264325 Cellulophaga lytica DSM 7489
10265204 Cellulophaga lytica DSM 7489
10282422 Weeksella virosa DSM 16922
10584999 Haliscomenobacter hydrossis DSM 1100
10725797 Sinorhizobium meliloti AK83
10741394 Sphingobium chlorophenolicum L-1
100192219 Danio rerio
100286831 Oryctolagus cuniculus
100303455 Ovis aries
2643 Homo sapiens
14528 Mus musculus
29244 Rattus norvegicus
396146 Gallus gallus
100136794 Oncorhynchus mykiss
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