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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping Metabotropic Glutamate Receptor 1 Antibodies (132) and Metabotropic Glutamate Receptor 1 Proteins (7) and many more products for this protein.
Showing 4 out of 18 products:
Human Metabotropic Glutamate Receptor 1 ELISA Kit - ABIN420429
Bovenschen, Spijkers, Wensink, Schellens, van Domselaar, van Baarle: Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation. in Clinical immunology (Orlando, Fla.) 2014
a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1, both of which were found to co-segregate with the intellectual disability.
It has the intrinsic ability to form a heteromeric complex with adenosine A1 receptor (show ADORA1 ELISA Kits) and mutually modulate signaling.
These data demonstrate that the approaches commonly used to study mGlu1 receptor function and signaling in other systems may be inappropriate for studying mGlu1 receptor-mediated melanoma cell viability.
Our results are likely relevant to human breast cancer, highlighting a putative role of mGluR1 in the pathophysiology of breast cancer and the potential of mGluR1 as a novel therapeutic target.
elevated glutamate (show GRIN1 ELISA Kits) secretion and mGluR1 expression play a role in Kaposi's sarcoma associated herpesvirus induced cell proliferation
alpha-actinin-4 (show ACTN4 ELISA Kits) is a novel group 1 mGluR (show GRM8 ELISA Kits)-interacting partner that orchestrates spine dynamics and morphogenesis in neurons.
Deleterious GRM1 mutations are associated with schizophrenia.
These novel mutations may contribute to the disease by alterations in GRM1 gene splicing, receptor activation, and post-receptor downstream signaling.
Results suggest a role for mGluR1 in breast cancer as a pro-angiogenic factor (show VEGFA ELISA Kits) as well as a mediator of tumor progression.
In mice expressing mutant beta-III spectrin (show SPTBN2 ELISA Kits), mGluR1 localization is altered at Purkinje cell dendritic spines.
Ionizing radiation is able to trigger the altered neuronal differentiation in undifferentiated neural stem-like cells through PI3K-STAT3 (show STAT3 ELISA Kits)-mGluR1 and PI3K-p53 (show TP53 ELISA Kits) signaling.
Because the mGluR1-PKCgamma (show PRKCG ELISA Kits) signaling pathway is essential for the late-phase of climbing fiber synapse elimination, this signaling pathway promotes the two key features of excitatory synaptic wiring in Purkinje cells.
Numb (show NUMB ELISA Kits) is a regulator for constitutive expression and dynamic transport of mGlu1.
CaMKIIalpha (show CAMK2 ELISA Kits) selectively regulates mGluR1a and mGluR5a ERK1/2 (show MAPK1/3 ELISA Kits) signaling.
STIM1 (show STIM1 ELISA Kits) is a key regulator of mGluR1-dependent Ca(2 (show CA2 ELISA Kits)+) signaling.
Selective photostimulation of astrocytes with channelrhodopsin-2 in primary visual cortex enhances both excitatory and inhibitory synaptic transmission, through the activation of type 1a metabotropic glutamate (show GRIN1 ELISA Kits) receptors.
Results provide unequivocal demonstration of the intrasynaptic localization of mGlu1 receptors in GABAergic synapses and confirm their peri (show POSTN ELISA Kits)-junctional enrichment in glutamatergic synapses
Activation of mGluR1 facilitates firing of molecular layer interneurons through the TRPC1 (show TRPC1 ELISA Kits)-mediated inward current, which depends on not only G protein-dependent but also Src (show SRC ELISA Kits)-ERK1/2 (show MAPK1/3 ELISA Kits)-dependent signaling pathways.
Homer (show HOMER1 ELISA Kits) 1a was neuroprotective against traumatic brain injury in vitro and in vivo, and this neuroprotection was associated with its effects on group I metabotropic glutamate (show GRIN1 ELISA Kits) receptors.
Stimulation of mGluR1 during glutamate (show GRIN1 ELISA Kits) exposure mediates prolonged epileptiform discharges in the hippocampus.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms\; some of which may have distinct functions.
metabotropic glutamate receptor 1
, metabotropic glutamate receptor A
, G protein coupled receptor, family C, group 1, member A
, G protein-coupled receptor, family C, group 1, member A
, G protein coupled receptor family C group 1 member A