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Metabotropic Glutamate Receptor 1 Products

(Glutamate Receptor, Metabotropic 1 (GRM1))
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms\; some of which may have distinct functions. [provided by RefSeq, Jul 2008].

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Featured Metabotropic Glutamate Receptor 1 Categories

Metabotropic Glutamate Receptor 1 Antibodies

High quality antibodies with extensive validation data.

Metabotropic Glutamate Receptor 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Metabotropic Glutamate Receptor 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Metabotropic Glutamate Receptor 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application FACS, ICC, IF, IP, LCI, WB
Validations
  • (5)
Cat. No. ABIN7043245
Quantity 25 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN7190883
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, FACS, ICC, IHC, Neut, WB
Validations
  • (3)
Cat. No. ABIN5611175
Quantity 0.1 mg
Datasheet Datasheet

Recommended Metabotropic Glutamate Receptor 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6956163
Quantity 96 tests
Datasheet Datasheet
Reactivity Goat
Analytical Method
Validations
Cat. No. ABIN1749404
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1772979
Quantity 96 tests
Datasheet Datasheet

Recommended Metabotropic Glutamate Receptor 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3081167
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3121237
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3081166
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our Metabotropic Glutamate Receptor 1 products

Tang, Liu, Xu, Zhang, Zhang, Zhou, Huang: "Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model." in: Brain, behavior, and immunity, Vol. 68, pp. 248-260, (2019) (PubMed).

Li, Corbelli, Watanabe, Armelloni, Ikehata, Parazzi, Pignatari, Giardino, Mattinzoli, Lazzari, Puliti, Cellesi, Zennaro, Messa, Rastaldi: "Three-dimensional podocyte-endothelial cell co-cultures: Assembly, validation, and application to drug testing and intercellular signaling studies." in: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Vol. 86, pp. 1-12, (2016) (PubMed).

Bovenschen, Spijkers, Wensink, Schellens, van Domselaar, van Baarle: "Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation." in: Clinical immunology (Orlando, Fla.), Vol. 150, Issue 1, pp. 1-11, (2014) (PubMed).

Dobi, Sartori, Busti, Van der Putten, Singewald, Shigemoto, Ferraguti: "Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice." in: Neuropharmacology, Vol. 66, pp. 274-89, (2013) (PubMed).

Neves, Shah, Liodis, Achimastou, Denaxa, Roalfe, Sesay, Walker, Pachnis: "The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex." in: Cerebral cortex (New York, N.Y. : 1991), Vol. 23, Issue 8, pp. 1811-23, (2013) (PubMed).

Coulon, Kanyshkova, Broicher, Munsch, Wettschureck, Seidenbecher, Meuth, Offermanns, Pape, Budde: "Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling." in: Frontiers in cellular neuroscience, Vol. 4, pp. 132, (2011) (PubMed).

Hirdes, Napp, Wulfsen, Schweizer, Schwarz, Bauer: "Erg K+ currents modulate excitability in mouse mitral/tufted neurons." in: Pflügers Archiv : European journal of physiology, Vol. 459, Issue 1, pp. 55-70, (2009) (PubMed).

Ferraguti, Crepaldi, Nicoletti: "Metabotropic glutamate 1 receptor: current concepts and perspectives." in: Pharmacological reviews, Vol. 60, Issue 4, pp. 536-81, (2008) (PubMed).

Namkoong, Shin, Lee, Marín, Wall, Goydos, Chen: "Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma." in: Cancer research, Vol. 67, Issue 5, pp. 2298-305, (2007) (PubMed).

Crepaldi, Lackner, Corti, Ferraguti: "Transcriptional activators and repressors for the neuron-specific expression of a metabotropic glutamate receptor." in: The Journal of biological chemistry, Vol. 282, Issue 24, pp. 17877-89, (2007) (PubMed).

Synonyms and alternative names related to Metabotropic Glutamate Receptor 1

glutamate metabotropic receptor 1 (GRM1), glutamate receptor, metabotropic 1a (grm1a), metabotropic glutamate receptor 1 (mGlutR1), glutamate receptor, metabotropic 1 (Grm1), glutamate receptor, metabotropic 1 (GRM1), 4930455H15Rik, ENSMUSG00000075319, fj39d05, GB18621, Glura, Gm10828, GPRC1A, Gprc1a, MGLU1, MGLUR1, mGluR1, mGlutR, nmf373, rcw, SCAR13, si:ch211-51a19.1, wobl, wu:fj39d05

Protein level used designations for Metabotropic Glutamate Receptor 1

  • metabotropic glutamate receptor 1
  • metabotropic glutamate receptor A
  • G protein coupled receptor, family C, group 1, member A
  • G protein-coupled receptor, family C, group 1, member A
  • G protein coupled receptor family C group 1 member A
  • mGluR1
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