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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping GRM2 Antibodies (98) and GRM2 Proteins (6) and many more products for this protein.
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this work offers new insights into the functioning of the mGlu2 receptor, which might contribute to the development of new and improved PAMs
Allosteric signaling through an mGlu2 and 5-HT2A (show HTR2A ELISA Kits) heteromeric receptor complex and its potential contribution to schizophrenia.
Study furthers our understanding of positive allosteric modulation of the mGlu2 receptor and can contribute to improved future design of mGlu2 modulators.
Findings suggest that mGluR2/3 and mGluR5s are unaltered in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia
Results demonstrate no changes in expression and density of both 5-HT2AR and mGlu2/3R in the postmortem prefrontal cortex of subjects with major depressive disorder under basal conditions; antidepressant treatment induces a decrease in 5-HT2AR density
Human anterior cingulate cortex from alcoholic patients shows a significant reduction in mGluR(2) transcripts compared to control subjects
Three residues located at the intracellular end of transmembrane domain four are necessary for the mGlu2 receptor binding to 5TR2A.
the promoter methylation of the GMR2 and GMR5 genes greatly decreased the risk of schizophrenia, and the expression level of the GRM2, GRM5 (show GRM5 ELISA Kits), and GRIA3 (show GRIA3 ELISA Kits) genes increased significantly in patients in comparison to healthy controls.
the structural properties for the H8 domain of the mGluR2 receptor; H8 behaves as a sensor of cholesterol concentration.
Only full-length dimeric mGlu2 activates G protein upon glutamate (show GRIN1 ELISA Kits) binding.
provided evidence that JARID1B via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB
Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2 (show CA2 ELISA Kits)+) transients and striatal field potentials.
In GRM2 knockout mice motor coordination and cognition is unchanged compared to GRM2/3 double knockout mice.
The findings support the possibility that interactions between mGlu2/3 and dopamine may be relevant to the pathophysiology and therapy of schizophrenia and other disorders
mGluR3 (show GRM3 ELISA Kits) knockouts did not differ from controls in reinstatement of drug-seeking behavior, suggesting that mGluR2 receptors are critical in mediating addictive-like behavior.
In the central nervous system, mGluR2 and mGluR4 (show GRM4 ELISA Kits) form a hetero-complex with a distinct pharmacological profile.
The reduction in the expression of mGluR2 and mGluR3 (show GRM3 ELISA Kits) may be involved in the development of benzodiazepine dependence.
5-HT(2A (show HTR2A ELISA Kits)) receptor-dependent signaling epigenetically affects mGlu2 transcription in mouse frontal cortex.
The mGluR2 subtype activates an inwardly rectifying potassium conductance in dendrites of the dentate gyrus.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.
glutamate metabotropic receptor 2
, glutamate receptor homolog
, metabotropic glutamate receptor 2
, G protein coupled receptor, family C, group 1, member B
, G protein-coupled receptor, family C, group 1, member B