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GRM2 Products

(Glutamate Receptor, Metabotropic 2 (GRM2))
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured GRM2 Categories

GRM2 Antibodies

High quality antibodies with extensive validation data.

GRM2 ELISA Kits

Reliable ELISA kits for a wide range of species.

GRM2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GRM2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IHC, ICC, FACS, Neut
Validations
  • (4)
Cat. No. ABIN5611158
Quantity 100 μL
Datasheet Datasheet
Reactivity Bat, Cow, Dog, Hamster, Human, Mouse, Pig, Rabbit, Rat
Application WB, IHC, IHC (p), ICC
Validations
  • (3)
Cat. No. ABIN1048929
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Monkey, Rabbit
Application IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN213522
Quantity 50 μg
Datasheet Datasheet

Recommended GRM2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1743299
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method
Validations
Cat. No. ABIN1774204
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1744518
Quantity 96 tests
Datasheet Datasheet

Recommended GRM2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7491675
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1355778
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
Cat. No. ABIN1330185
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our GRM2 products

So, Fong, Chen, Hui, Ng, Cherny, Mak, Cheung, Chan, Chen, Li, Sham: "Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 1, pp. 103-13, (2009) (PubMed).

Anneser, Chahli, Ince, Borasio, Shaw: "Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 8, pp. 831-40, (2004) (PubMed).

Francesconi, Cammalleri, Sanna: "The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region." in: Brain research, Vol. 1022, Issue 1-2, pp. 12-8, (2004) (PubMed).

Bhattacharya, Babwah, Godin, Anborgh, Dale, Poulter, Ferguson: "Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 40, pp. 8752-61, (2004) (PubMed).

Krampfl, Schlesinger, Zörner, Kappler, Dengler, Bufler: "Control of kinetic properties of GluR2 flop AMPA-type channels: impact of R/G nuclear editing." in: The European journal of neuroscience, Vol. 15, Issue 1, pp. 51-62, (2002) (PubMed).

Dietrich, Kral, Clusmann, Friedl, Schramm: "Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus." in: Neuropharmacology, Vol. 42, Issue 3, pp. 297-305, (2002) (PubMed).

Wilson, Nicoll: "Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses." in: Nature, Vol. 410, Issue 6828, pp. 588-92, (2001) (PubMed).

Synonyms and alternative names related to GRM2

glutamate metabotropic receptor 2 (GRM2), glutamate receptor, metabotropic 2 (Grm2), glutamate metabotropic receptor 2 (Grm2), 4930441L02Rik, GLUR2, GPRC1B, Gprc1b, mGlu2, MGLUR2, mGluR2, mGluR7

Protein level used designations for GRM2

  • glutamate metabotropic receptor 2
  • glutamate receptor homolog
  • metabotropic glutamate receptor 2
  • G protein coupled receptor, family C, group 1, member B
  • G protein-coupled receptor, family C, group 1, member B
  • mGluR2
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