GRM2 Products
(Glutamate Receptor, Metabotropic 2 (GRM2))
Categories
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured GRM2 Categories
GRM2 Antibodies
High quality antibodies with extensive validation data.
GRM2 ELISA Kits
Reliable ELISA kits for a wide range of species.
GRM2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GRM2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC, ICC, FACS, Neut
Validations
- (4)
Cat. No.
ABIN5611158
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Bat, Cow, Dog, Hamster, Human, Mouse, Pig, Rabbit, Rat
Application
WB, IHC, IHC (p), ICC
Validations
- (3)
Cat. No.
ABIN1048929
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Monkey, Rabbit
Application
IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN213522
Quantity
50 μg
Datasheet
Datasheet
Recommended GRM2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1745737
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1744518
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Monkey
Analytical Method
Validations
Cat. No.
ABIN1770532
Quantity
96 tests
Datasheet
Datasheet
Recommended GRM2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355778
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3081168
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3121631
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our GRM2 products
: "Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 1, pp. 103-13, (2009) (PubMed).: "Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 8, pp. 831-40, (2004) (PubMed).
: "The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region." in: Brain research, Vol. 1022, Issue 1-2, pp. 12-8, (2004) (PubMed).
: "Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 40, pp. 8752-61, (2004) (PubMed).
: "Control of kinetic properties of GluR2 flop AMPA-type channels: impact of R/G nuclear editing." in: The European journal of neuroscience, Vol. 15, Issue 1, pp. 51-62, (2002) (PubMed).
: "Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus." in: Neuropharmacology, Vol. 42, Issue 3, pp. 297-305, (2002) (PubMed).
: "Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses." in: Nature, Vol. 410, Issue 6828, pp. 588-92, (2001) (PubMed).
Synonyms and alternative names related to GRM2
glutamate metabotropic receptor 2 (GRM2), glutamate receptor, metabotropic 2 (Grm2), glutamate metabotropic receptor 2 (Grm2), 4930441L02Rik, GLUR2, GPRC1B, Gprc1b, mGlu2, MGLUR2, mGluR2, mGluR7Protein level used designations for GRM2
- glutamate metabotropic receptor 2
- glutamate receptor homolog
- metabotropic glutamate receptor 2
- G protein coupled receptor, family C, group 1, member B
- G protein-coupled receptor, family C, group 1, member B
- mGluR2
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