Guanylate Cyclase Activator 2B (Uroguanylin) Proteins (GUCA2B)

GUCA2B encodes a member of the guanylin family, and is expressed in the stomach and intestine. Additionally we are shipping GUCA2B Antibodies (56) and GUCA2B Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat GUCA2B GUCA2B 64055 P70668
Mouse GUCA2B GUCA2B 14916 O09051
GUCA2B 2981 Q16661
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

GUCA2B Proteins by Origin and Source

Origin Expressed in Conjugate

More Proteins for Guanylate Cyclase Activator 2B (Uroguanylin) (GUCA2B) Interaction Partners

Mouse (Murine) Guanylate Cyclase Activator 2B (Uroguanylin) (GUCA2B) interaction partners

  1. guanylin (show GUCA2A Proteins) and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage

  2. In obese mice UGN expression was decreased, whereas leptin (show LEP Proteins) treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT.

  3. UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site.

  4. findings establish a role for uroguanylin in an enteric-renal communication axis as well as a fundamental principle of this axis in the maintenance of salt homeostasis in vivo

  5. act on the mouse kidney, in part, through a cGMP-dependent, GC-C (show GUCY2C Proteins)-independent mechanism, causing significant natriuresis by renal tubular processes.

  6. existence of two signaling pathways for guanylin (show GUCA2A Proteins) peptides in principal cells of mouse cortical collecting duct of kidney

  7. Role for uroguanylin in fluid homeostasis and as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading.

Human Guanylate Cyclase Activator 2B (Uroguanylin) (GUCA2B) interaction partners

  1. The simulations suggested that all missense SNPs considered as convergent deleterious caused some kind of structural change to the uroguanylin peptide. Additionally, four of these SNPs were also shown to cause modifications in peptide flexibility, possibly resulting in functional changes.

  2. The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines.

  3. Uroguanylin concentrations are increased in patients with chronic renal failure, nephrotic syndrome, or those on dialysis.

GUCA2B Protein Profile

Protein Summary

This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues.

Gene names and symbols associated with GUCA2B

  • guanylate cyclase activator 2B (uroguanylin) (GUCA2B)
  • guanylate cyclase activator 2B (Guca2b)
  • guanylate cyclase activator 2b (retina) (Guca2b)
  • AV066530 protein
  • GCAP-II protein
  • Gcap2 protein
  • GUCA2B protein
  • UGN protein

Protein level used designations for GUCA2B

guanylate cyclase activator 2B (uroguanylin) , guanylate cyclase activator 2B , guanylate cyclase activator 2b (retina) , uroguanylin , granule cell antiserum positive 2 , guanylyl cyclase activating peptide II

469301 Pan troglodytes
699525 Macaca mulatta
515664 Bos taurus
64055 Rattus norvegicus
14916 Mus musculus
100135535 Cavia porcellus
2981 Homo sapiens
100301561 Sus scrofa
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