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HLA-DRB1 belongs to the HLA class II beta chain paralogs. Additionally we are shipping HLA-DRB1 Antibodies (53) and HLA-DRB1 Proteins (25) and many more products for this protein.
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In late-onset SLE, HLA DR17 (DR3 (show TNFRSF25 ELISA Kits)) was found more frequently compared with individuals without autoimmune disease.
The observed positive association between integrated HIV-1 DNA load and frequency of CD8 (show CD8A ELISA Kits)(+)DR/DP/DQ(+) cells indicates that a close correlation between HIV persistence and immune activation continues during consistently suppressive therapy.
HLA-DRB1*04 alleles are associated with pulmonary tuberculosis;the subtype HLA-DRB1*04:11:01 (p = 0.0019; OR = 2.23; 95% CI = 1.34 to 3.70) was associated with susceptibility to disease, while DRB1*04:07:01 (p<0.0001; OR = 0.02; 95% CI = 0.001 to 0.33)to protection.
The negative association we describe here supports the idea that the HLA-DRB1 *13 allele, possibly by its specific structural features, may as well confer resistance to several other AIDs.
Data indicate that the strongest risk factor for systemic juvenile idiopathic arthritis (sJIA) was HLA-DRB1*11.
alleles DRB1*01:01, DQ4, DQ7 and DQ8 are considered as susceptible to egg allergy
One of the associated variants was also found to be linked with increased expression of MERTK (show MERTK ELISA Kits) in monocytes and higher expression of MERTK (show MERTK ELISA Kits) was associated with either increased or decreased risk of developing MS, dependent upon HLA-DRB1*15:01 status.
This study shows the universal applicability of the RNA-based sequencing approach to identify full-length coding sequences and to define the polymorphic content of HLA-DRB1 alleles.
A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.
We found association of three variants in the region harboring genes encoding the class II human leukocyte antigens (HLAs): both located between HLA-DQA1 and HLA-DRB1
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
major histocompatibility complex, class II, DR beta 1
, HLA class II histocompatibility antigen, DR-1 beta chain
, MHC class II HLA-DR beta 1 chain
, MHC class II HLA-DR-beta cell surface glycoprotein
, MHC class II HLA-DRw10-beta
, MHC class II antigen
, human leucocyte antigen DRB1
, lymphocyte antigen DRB1