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HLA-DRB1 belongs to the HLA class II beta chain paralogs. Additionally we are shipping HLA-DRB1 Antibodies (198) and HLA-DRB1 Kits (7) and many more products for this protein.
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Subjects with HLA DRB1*04:05-DQB1*04:01 haplotype were more likely to show weight loss than those without in type 1 diabetes.
Report association of HLA-DRB1*07 haplotype with steroid resistant nephrotic syndrome.
HLA-DRB1 *1 and *11 allele polymorphisms were protective factors, *12 and *14 allele polymorphisms were risk factors for hepatocellular carcinoma development.
X-rays of hands, feet and knees showed characteristic features of erosive hand osteoarthritis (EHOA), psoriatic arthritis (PsA) and chondrocalcinosis (CC)/pseudogout. Furthermore, HLA typing evinces the presence of HLA C*06; DRB*01 07 and HLA C*07; DRB*01 *11 alleles, respectively, predisposing factors of these inflammatory diseases. [review]
A number of HLA-DRB1 alleles and haplotypes showed susceptible (DRB1*11, DRB1*04 DRB1*03) and protective (DRB1*10) association(s) in T2DM patients from south India.
HLA-DRB1 allele polymorphisms are associated with nasopharyngeal carcinoma.
this study shows that none of the HLA-DRB*1 genotypes are observed to increase the susceptibility of North Indian children to Henoch-Schonlein purpura
Combination of HLA-B*15:01 and DRB1*15:01 is associated with interstitial lung disease in Japanese patients with advanced pancreatic cancer receiving gemcitabine plus erlotinib.
The HLA-DR observed on CD4 (show CD4 Proteins)+ T cells was almost exclusively cell surface-associated, while for autologous CD19 (show CD19 Proteins)+ B cells, the protein could be located in the plasma membrane as well as in the cytoplasm.
HLA-DRB1*04:02, DRB1*14:04, HLA-DQB1* 03:02 and DQB1*05:03 alleles and HLA-DRB1*04:02-DQB1*03:02 and HLA-DRB1*14:04-DQB1*05:03 haplotypes are genetic markers for susceptibility for pemphigus vulgaris, while DRB1*11 allelic group appears protective in Serbian population.
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
major histocompatibility complex, class II, DR beta 1
, HLA class II histocompatibility antigen, DR-1 beta chain
, MHC class II HLA-DR beta 1 chain
, MHC class II HLA-DR-beta cell surface glycoprotein
, MHC class II HLA-DRw10-beta
, MHC class II antigen
, human leucocyte antigen DRB1
, lymphocyte antigen DRB1