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HLA-DRB1 belongs to the HLA class II beta chain paralogs. Additionally we are shipping HLA-DRB1 Antibodies (53) and HLA-DRB1 Kits (7) and many more products for this protein.
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The carrier frequency of the HLA-DRB1*01 was higher in mixed connective tissue disease patients compared with controls, although the differences were not statistically significant.
Significant increases in type 1 diabetes risk resulted from harboring the alleles HLA-DRB1*03:01 and HLA-DRB1*04:05. (Meta-analysis)
the HLA-DRB1* haplotype appeared complementary with current serologic tools to predict good and poor responders in a treat to target strategy.
HLA-DRB1*03 is associated with microalbuminuria in type 1 diabetes. HLA-DRB1*04 had no association.
Positive association of DRB1*03 allele with Atopic Bronchial Asthma has been found in Uzbek population.
DRB1*04 (DR4) (41/214 vs 42/400, Pc = 0.042, OR = 2.02, 95% CI 1.27-3.22) and DQB1*0302 (35/214 vs 32/400, Pc = 0.014, OR = 2.25, 95% CI 1.35-3.75) had significant positive association with AChR MG compared to controls, and
In late-onset SLE, HLA DR17 (DR3 (show TNFRSF25 Proteins)) was found more frequently compared with individuals without autoimmune disease.
The observed positive association between integrated HIV-1 DNA load and frequency of CD8 (show CD8A Proteins)(+)DR/DP/DQ(+) cells indicates that a close correlation between HIV persistence and immune activation continues during consistently suppressive therapy.
HLA-DRB1*04 alleles are associated with pulmonary tuberculosis;the subtype HLA-DRB1*04:11:01 (p = 0.0019; OR = 2.23; 95% CI = 1.34 to 3.70) was associated with susceptibility to disease, while DRB1*04:07:01 (p<0.0001; OR = 0.02; 95% CI = 0.001 to 0.33)to protection.
The negative association we describe here supports the idea that the HLA-DRB1 *13 allele, possibly by its specific structural features, may as well confer resistance to several other AIDs.
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
major histocompatibility complex, class II, DR beta 1
, HLA class II histocompatibility antigen, DR-1 beta chain
, MHC class II HLA-DR beta 1 chain
, MHC class II HLA-DR-beta cell surface glycoprotein
, MHC class II HLA-DRw10-beta
, MHC class II antigen
, human leucocyte antigen DRB1
, lymphocyte antigen DRB1