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HLA Class II DR beta 1 Proteins (HLA-DRB1)

HLA-DRB1 belongs to the HLA class II beta chain paralogs. Additionally we are shipping HLA-DRB1 Antibodies (53) and HLA-DRB1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HLA-DRB1 3123 P01912,P01911,Q29974
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Top HLA-DRB1 Proteins at antibodies-online.com

Showing 5 out of 25 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HLA-DRB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for HLA Class II DR beta 1 (HLA-DRB1) Interaction Partners

Human HLA Class II DR beta 1 (HLA-DRB1) interaction partners

  1. The carrier frequency of the HLA-DRB1*01 was higher in mixed connective tissue disease patients compared with controls, although the differences were not statistically significant.

  2. Significant increases in type 1 diabetes risk resulted from harboring the alleles HLA-DRB1*03:01 and HLA-DRB1*04:05. (Meta-analysis)

  3. the HLA-DRB1* haplotype appeared complementary with current serologic tools to predict good and poor responders in a treat to target strategy.

  4. HLA-DRB1*03 is associated with microalbuminuria in type 1 diabetes. HLA-DRB1*04 had no association.

  5. Positive association of DRB1*03 allele with Atopic Bronchial Asthma has been found in Uzbek population.

  6. DRB1*04 (DR4) (41/214 vs 42/400, Pc = 0.042, OR = 2.02, 95% CI 1.27-3.22) and DQB1*0302 (35/214 vs 32/400, Pc = 0.014, OR = 2.25, 95% CI 1.35-3.75) had significant positive association with AChR MG compared to controls, and

  7. In late-onset SLE, HLA DR17 (DR3 (show TNFRSF25 Proteins)) was found more frequently compared with individuals without autoimmune disease.

  8. The observed positive association between integrated HIV-1 DNA load and frequency of CD8 (show CD8A Proteins)(+)DR/DP/DQ(+) cells indicates that a close correlation between HIV persistence and immune activation continues during consistently suppressive therapy.

  9. HLA-DRB1*04 alleles are associated with pulmonary tuberculosis;the subtype HLA-DRB1*04:11:01 (p = 0.0019; OR = 2.23; 95% CI = 1.34 to 3.70) was associated with susceptibility to disease, while DRB1*04:07:01 (p<0.0001; OR = 0.02; 95% CI = 0.001 to 0.33)to protection.

  10. The negative association we describe here supports the idea that the HLA-DRB1 *13 allele, possibly by its specific structural features, may as well confer resistance to several other AIDs.

HLA-DRB1 Protein Profile

Protein Summary

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Gene names and symbols associated with HLA-DRB1

  • major histocompatibility complex, class II, DR beta 1 (hla-drb1)
  • major histocompatibility complex, class II, DR beta 1 (HLA-DRB1)
  • DRB1 protein
  • DRw10 protein
  • HLA-DR1B protein
  • HLA-DRB protein
  • MGC108235 protein
  • SS1 protein

Protein level used designations for HLA-DRB1

major histocompatibility complex, class II, DR beta 1 , DW2.2/DR2.2 , HLA class II histocompatibility antigen, DR-1 beta chain , MHC class II HLA-DR beta 1 chain , MHC class II HLA-DR-beta cell surface glycoprotein , MHC class II HLA-DRw10-beta , MHC class II antigen , human leucocyte antigen DRB1 , lymphocyte antigen DRB1

GENE ID SPECIES
734125 Xenopus (Silurana) tropicalis
3123 Homo sapiens
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