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May act as a transcription factor that could act on to regulate one of the phases of hair growth.. Additionally we are shipping Hairless Proteins (5) and many more products for this protein.
Showing 10 out of 29 products:
Cow (Bovine) Polyclonal HR Primary Antibody for WB - ABIN2777657
Xie, Chang, Oda, Bikle: Hairless suppresses vitamin D receptor transactivation in human keratinocytes. in Endocrinology 2005
This study examinedthe uncommon phenotype and using microarray analyses and functional studies, we found that beta-catenin (show CTNNB1 Antibodies) was mediated by Hr. Progenitor keratinocytes from the bulge region differentiate into both epidermis and sebaceous glands, and fail to adopt the hair keratinocytes fate in the mutant scalp, due to the decreased Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling in the absence of the hairless protein.
HR regulates expression of genes in the MSX2 regulatory pathway, which explains abnormal hair follicle formation in Hr(Hp)/Hr(Hp) skin.
Hairless is required for adipocyte differentiation.
Hr loss results in a state of uncontrolled epidermal proliferation that promotes tumor development, and Hr mutant mice should no longer be considered merely hairless 'wild-type' mice
regulation of Dlx3 (show DLX3 Antibodies) by HR affects the IRS (show IARS Antibodies) keratin expression, thus modulating the formation of IRS (show IARS Antibodies) of hair follicle.
Foxe1 (show FOXE1 Antibodies) mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes.
Hr evokes an anti-apoptotic response by disrupting a p53 (show TP53 Antibodies) dependent pathway involving Bcl2 (show BCL2 Antibodies) family members.
hairless phenotype in CR rats is not allelic with mouse hairless
This thyroid hormone (show PTH Antibodies)-regulated corepressor associates with histone deacetylases in neonatal rat brain.
HR regulates the precise timing of Wnt (show WNT2 Antibodies) signaling required for hair follicle regeneration.
This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.
, protein hairless
, hairless homolog (mouse)
, hairless protein
, protein hairless-like