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Heme Oxygenase (Decycling) 1 Proteins (HMOX1)

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Additionally we are shipping Heme Oxygenase (Decycling) 1 Antibodies (356) and Heme Oxygenase (Decycling) 1 Kits (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HMOX1 3162 P09601
HMOX1 15368 P14901
HMOX1 24451 P06762
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Top Heme Oxygenase (Decycling) 1 Proteins at

Showing 10 out of 36 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 3 to 4 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
HOST_Escherichia coli (E. coli) Wild boar His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 5 Days
HOST_Escherichia coli (E. coli) Human His tag,S tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

HMOX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,

Top referenced Heme Oxygenase (Decycling) 1 Proteins

  1. Rat (Rattus) HMOX1 Protein expressed in Escherichia coli (E. coli) - ABIN1686745 : Brydun, Watari, Yamamoto, Okuhara, Teragawa, Kono, Chayama, Oshima, Ozono: Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis. in Hypertension research : official journal of the Japanese Society of Hypertension 2007 (PubMed)
    Show all 5 references for ABIN1686745

  2. Human HMOX1 Protein expressed in Escherichia coli (E. coli) - ABIN666727 : Soares, Brouard, Smith, Bach: Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs. in Immunological reviews 2002 (PubMed)
    Show all 2 references for ABIN666727

More Proteins for Heme Oxygenase (Decycling) 1 (HMOX1) Interaction Partners

Soybean (Glycine max) Heme Oxygenase (Decycling) 1 (HMOX1) interaction partners

  1. study evaluated the time-course of HO-1 and catalase (show CAT Proteins) gene expressions in nodules and roots of soybean plants subjected to cadmium treatment

Xenopus laevis Heme Oxygenase (Decycling) 1 (HMOX1) interaction partners

  1. Data suggest expression of hsp32 is up-regulated in kidney epithelial cells upon in vitro exposure to heavy metal water pollutants (Cd, As) or proteasomal inhibitors (MG132, withaferin A, celastrol); heat shock may be synergistic factor.

Zebrafish Heme Oxygenase (Decycling) 1 (HMOX1) interaction partners

  1. Suggest that Gata-1 (show GATA1 Proteins) and Nrf2a (show NFE2L2 Proteins) play differential roles in regulating the heme degradation enzymes hmox1a/bvra (show BLVRA Proteins)/bvrb (show BLVRB Proteins) during an early developmental period of heightened cellular stress.

  2. Bach1 (show BACH1 Proteins) regulates the liver specificity and transience of the Nrf2a (show NFE2L2 Proteins)-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Proteins) inhibition based on its level in each tissue.

Arabidopsis thaliana Heme Oxygenase (Decycling) 1 (HMOX1) interaction partners

  1. Data indicate that Heme oxygenase 1 (HY1) functioned negatively and acted upstream of ABSCISIC ACID-INSENSITIVE4 (ABI4) in drought signaling.

  2. HY1 confers cadmium tolerance by decreasing nitric oxide production and improving iron homeostasis.

  3. Data indicate that AtHO1 (HY1; heme oxygenase-1)-overexpressing plants generated more NO, whereas knock-down of AtHO1 expression reduced the level of nitric oxide (NO) in plants.

  4. HY1 mutant exhibited progressive salt hypersensitivity.

  5. Disrupting the binding of the AtHBP5 to haem oxygenase 1 (HY1) leads to oxidative stress.

  6. Mutation of HY1 causes UV-C hypersensitivity by impairing carotenoid and flavonoid biosynthesis and the down-regulation of antioxidant defence.

  7. HY1 and HY5 additively regulate the expression of light regulated genes and accumulation of chlorophyll and anthocyanin during early seedling development.

  8. HY1 (Heme oxygenase 1) plays an important role in salt acclimation.

  9. all members of the HO1 subfamily (HY1, HO3 and HO4) are active monomeric HOs and can convert haem to BV IXalpha using spinach Fd (ferredoxin) as an electron donor

Synechocystis PCC 6803 Heme Oxygenase (Decycling) 1 (HMOX1) interaction partners

  1. HO2 (show HMOX2 Proteins) has an activity high enough to substitute for HO1 under aerobic conditions.

Human Heme Oxygenase (Decycling) 1 (HMOX1) interaction partners

  1. Colorectal tumor had lower Hmox1 mRNA levels than the normal tissue. The ratio of Hmox1/Nrf2 (show GABPA Proteins) mRNA level was a predictor for distant metastasis in colorectal cancer.

  2. Data show that periostin (show POSTN Proteins) mitigates high glucose-induced mitochondrial apoptosis in endothelial cells, via activation of nuclear factor erythroid 2-related factor 2 (Nrf2 (show NFE2L2 Proteins))/heme oxygenase-1 (HO-1) signaling.

  3. The present result suggested the inhibitory action of HO1 in the avoidance of a potentially enhanced linkage between autophagy and apoptosis, particularly in the setting of excessive ROS (show ROS1 Proteins).

  4. Overexpression of ALDH2 (show ALDH2 Proteins) increased cell survival against GTN (show GNAT3 Proteins)-induced cytotoxicity and conferred protection from oxidative damage resulting from nitrate tolerance, accompanied by decreased production of intracellular reactive oxygen species and reduced expression of heme oxygenase 1.

  5. ROC curve analysis revealed high specificity and sensitivity of HO-1 expression in predicting relapse and acute graft versus host disease after allo-hematopoietic stem cell transplantation.

  6. long (GT)n repeat polymorphisms of promoter and decreased serum HO-1 levels associated with a higher susceptibility to laryngeal squamous cell carcinoma and vocal cord leukoplakia

  7. Down regulated miR (show MLXIP Proteins)-196a2 may be involved in intestinal Behcet's disease pathogenesis by targeting Bach1 (show BACH1 Proteins)/ho-1.

  8. The present study suggests a weak association between HMOX2 (show HMOX2 Proteins) rs1051308 polymorphism and the risk to develop multiple sclerosis (MS) in Spanish Caucasian men and a trend towards association between the HMOX1 rs2071746A and MS risk.

  9. The data demonstrate the important role of HO-1 in the pathogenesis and tumorigenesis of Kaposi's Sarcoma-associated Herpesvirus-infected endothelial cells, the underlying regulatory mechanisms for HO-1 expression and targeting HO-1 may represent a promising therapeutic strategy against Kaposi's Sarcoma-associated Herpesvirus-related malignancies.

  10. Study identified that esophageal squamous cell carcinoma (ESCC) tumors frequently expressed HO-1 and showed that blocking its expression in ESCC cell lines resulted in decreased cellular proliferation, increased reactive oxygen species levels, and increased cellular apoptosis.

Pig (Porcine) Heme Oxygenase (Decycling) 1 (HMOX1) interaction partners

  1. findings collectively suggest that miR (show MYLIP Proteins)-506 acts as a tumor suppressor via regulation of ROCK1 (show ROCK1 Proteins) expression and may thus be a promising therapeutic target for HCC (show FAM126A Proteins)

  2. Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.

  3. Down-regulation of HO-1 is associated with pulmonary arterial hypertension and right ventricular failure.

  4. The study revealed the involvement of HO-1 in classical swine fever virus proliferation.

  5. The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.

  6. Glutamate (show GRIN2C Proteins) regulates Ca2 (show CA2 Proteins)+ signals in smooth muscle cells of newborn piglet brain slice arterioles through astrocyte- and heme oxygenase-dependent mechanisms.

  7. obalt protoporphyrin prevents postictal cerebral vascular dysfunction by upregulating HO-1.

  8. Data demonstrate that lipopolysaccharides evoke a heat shock response, with an increase heat shock proteins 70 and Hsp32) and of VEGF (show VEGFA Proteins), a specific endothelial cell growth factor (show FGF1 Proteins).

  9. Interaction of soluble factors in plasma possibly generated during PICSO are not responsible for upregulation of HO-1 and VEGF mRNA.

Cow (Bovine) Heme Oxygenase (Decycling) 1 (HMOX1) interaction partners

  1. the data were consistent with HO-1 acting as an anti-viral factor and these findings suggested that induction of HO-1 may be a useful prevention and treatment strategy against BVDV infection.

  2. These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 (show NFE2L2 Proteins) expression early in the course of infection, which results in increased expression of HO-1 within these cells.

  3. investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: regulation of HO-1 gene expression in aortic endothelial cells by advanced glycation end products

  4. Sickle blood increases endothelial heme oxygenase activity.

  5. data provide evidence for the involvement of the thioredoxin/thioredoxin (show TXN Proteins) receptor system, in the regulation of haem oxygenase-1 expression in aortic endothelial cells during pro-oxidant challenge

  6. Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD/SOD3 (show SOD3 Proteins).

Mouse (Murine) Heme Oxygenase (Decycling) 1 (HMOX1) interaction partners

  1. Data indicate that heme oxygenase-1 (HO-1)-mediated downregulation of NF-kappa B (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) was involved in the anti-psoriatic effect of Terminalia chebulanin (TC).

  2. HO-1 was upregulated in spinal cord microglial cells after spinal nerve injury.

  3. tussilagonone exerts its anti-inflammatory effects via upregulation of HO-1 expression

  4. Demonstrate role for heme oxygenase 1 inhibitor zinc protoporphyrin in the treatment of neonatal hyperbilirubinemia caused by hemolytic diseases.

  5. Our results suggest a protective function of HO-1 induction in psoriasis. The protective effect of HO-1 may be attributed to its effect on the Stat3 signaling pathway via increased SHP-1 expression.

  6. Our findings establish the HO-1/CO system and redox regulation of mitochondrial biogenesis as essential factors in ES cell differentiation as well as in the subsequent maturation of these cells into functional cardiac cells.

  7. LPS (show TLR4 Proteins)-stimulated TNF-alpha (show TNF Proteins) was significantly decreased, whereas IRG1 and A20 (show TNFAIP3 Proteins) were increased by CORM-2 application and HO-1 induction, which in turn were abrogated by ZnPP.

  8. 4,7-Dimethoxy-5-methyl-1,3-benzodioxole from Antrodia camphorata increased hemoxygenase-1 expression in macrophages

  9. These results suggest that RvD1 could effectively prevent CCl4 (show CCL4 Proteins)-induced liver injury by inhibition of oxidative stress and inflammation, and the underlying mechanism may be related to up-regulation of HO-1.

  10. Our findings demonstrate that DEE and a fraction derived from this extract exerts anti-inflammatory effects through Nrf2dependent HO-1 expression

Rabbit Heme Oxygenase (Decycling) 1 (HMOX1) interaction partners

  1. Ligustrazine injection possesses notable protective effects on ischemia/reperfusion injury in rabbits by increasing the expression of HO-1 in lung.

  2. Results add new evidence for the importance of HO-1 in the genesis and development of atherosclerosis and provide several possible mechanisms underlying the anti-atherosclerosis effects of HO-1

  3. the effect of HO-1 on the progression and stabilization of vulnerable plaques and the possible mechanism

  4. Heme-L-lysinate could attenuate atherosclerotic progression through upregulating HO-1 and HSP70 (show HSP70 Proteins) expression and increasing CO production.

  5. These results suggest that HO-1 is important in limiting in-stent stenosis and can be regarded as a new therapeutic target.

  6. Statins showed anti-atherosclerotic effects mediated by HO-1/eNOS (show NOS3 Proteins), restoring the [NO]/[ONOO(-)] imbalance and reducing lipid peroxidation.

  7. HO-1/CO system was activated and may be one of the protective signal pathway during pulmonary ischemia-reperfusion injury in rabbits.

  8. HO-1 contributes to vascular repair by increasing circulating endothelial progenitor cells (EPCs) derived from the bone marrow.

Heme Oxygenase (Decycling) 1 (HMOX1) Protein Profile

Protein Summary

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.

Gene names and symbols associated with HMOX1

  • heme oxygenase (decycling) 1 (HMOX1)
  • heme oxygenase 1 (HO1)
  • heme oxygenase (decycling) 1 (hmox1)
  • heme oxygenase 1 (TED4)
  • heme oxygenase (ho1)
  • heme oxygenase (CPE0214)
  • heme oxygenase 1 (ho1)
  • Heme oxygenase (ho1)
  • heme oxygenase 1 (AM1_C0205)
  • heme oxygenase 1 (CC1G_11686)
  • heme oxygenase 1 (CpipJ_CPIJ007246)
  • Heme oxygenase (Cyan7425_2962)
  • heme oxygenase (decycling) 1 (Hmox1)
  • ATHO1 protein
  • bK286B10 protein
  • D8Wsu38e protein
  • F18A8.4 protein
  • F18A8_4 protein
  • GUN2 protein
  • HEME OXYGENASE protein
  • HEME OXYGENASE 1 protein
  • HEME OXYGENASE 6 protein
  • Hemox protein
  • Heox protein
  • HEOXG protein
  • Hmox protein
  • Hmox1 protein
  • HMOX1D protein
  • Ho-1 protein
  • Ho1 protein
  • hsp32 protein
  • HY1 protein
  • HY6 protein
  • MGC132176 protein
  • wu:fc27c04 protein
  • zgc:65984 protein

Protein level used designations for HMOX1

heme oxygenase (decycling) 1 , heme oxygenase 1 , fc27c04 , heme oxygenase , Heme oxygenase , heat shock protein, 32-kD , HO-1 , heat shock protein 32 , heme oxygenase (decyclizing) 1 , P32 protein , hemoxygenase , heme oxygenase-1

470195 Pan troglodytes
547612 Glycine max
719266 Macaca mulatta
734976 Xenopus laevis
791518 Danio rerio
817208 Arabidopsis thaliana
953483 Synechocystis sp. PCC 6803
988459 Clostridium perfringens str. 13
1012610 Thermosynechococcus elongatus BP-1
1463132 Prochlorococcus marinus subsp. marinus str. CCMP1375
1726356 Prochlorococcus marinus subsp. pastoris str. CCMP1986
1732486 Synechococcus sp. WH 8102
4718538 Prochlorococcus marinus str. AS9601
4719905 Prochlorococcus marinus str. MIT 9515
4778405 Prochlorococcus marinus str. MIT 9303
4779884 Prochlorococcus marinus str. NATL1A
4911675 Prochlorococcus marinus str. MIT 9301
5157291 Synechococcus sp. RCC307
5615689 Prochlorococcus marinus str. MIT 9215
5686060 Acaryochloris marina MBIC11017
5730157 Prochlorococcus marinus str. MIT 9211
5862292 Microcystis aeruginosa NIES-843
6012319 Coprinopsis cinerea okayama7130
6039118 Culex quinquefasciatus
7288894 Cyanothece sp. PCC 7425
3162 Homo sapiens
445512 Sus scrofa
513221 Bos taurus
15368 Mus musculus
24451 Rattus norvegicus
442987 Canis lupus familiaris
100715748 Cavia porcellus
396287 Gallus gallus
100173339 Pongo abelii
100008919 Oryctolagus cuniculus
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