HMOX1 Protein
Quick Overview for HMOX1 Protein (ABIN7318568)
Target
See all HMOX1 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human HO-1/HMOX1 Protein
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Sequence
- Met 1-Thr 261
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Characteristics
- Recombinant Human Heme Oxygenase 1 is produced by our E.coli expression system and the target gene encoding Met1-Thr261 is expressed.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Heme Oxygenase (Decycling) 1 (HMOX1) (AA 1-288) protein (His tag)
custom-made HMOX1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Heme Oxygenase (Decycling) 1 (HMOX1) (AA 1-288) protein (GST tag)HMOX1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Heme Oxygenase (Decycling) 1 (HMOX1) (AA 1-266) protein (His tag)HMOX1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS
Heme Oxygenase (Decycling) 1 (HMOX1) (AA 1-267) protein (His-IF2DI Tag)HMOX1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Heme Oxygenase (Decycling) 1 (HMOX1) (AA 1-261) protein (His-IF2DI Tag)HMOX1 Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))
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Alternative Name
- HO-1/HMOX1
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Background
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Background: Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.
Synonym: Heme Oxygenase 1, HO-1, HMOX1, HO, HO1
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Molecular Weight
- 29.9 kDa
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UniProt
- P09601
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Pathways
- Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome
Target
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